Pitfalls in the Use of DNA Microarray Data for Diagnostic and Prognostic Classification

Many studies profiling gene expression in human cancers have been completed and are in progress. Some studies (19-22) attempt to build predictors of patient prognosis and response to therapy by using gene expression profiles. Because it is likely that gene expression profiles will provide informatio...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2003-01, Vol.95 (1), p.14-18
Hauptverfasser:	Simon, Richard, Radmacher, Michael D., Dobbin, Kevin, McShane, Lisa M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cluster Analysis Confounding Factors (Epidemiology) Deoxyribonucleic acid Diagnosis, Differential Diagnostics DNA DNA, Neoplasm - analysis Humans Medical sciences Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasms - diagnosis Neoplasms - genetics Oligonucleotide Array Sequence Analysis Predictive Value of Tests Prognosis Reproducibility of Results Research Design Statistical analysis Tumors
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