Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones

A series of hydroxyacetophenones was prepared for evaluation as leukotriene B4 (LTB4) receptor antagonists, culminating in 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5- yl)heptyl]oxy]phenyl]ethanone (compound 35, LY255283). Using an assay for inhibition of specific [3H]LTB4 binding to human PM...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1992-05, Vol.35 (10), p.1818-1828
Hauptverfasser:	Herron, David K, Goodson, Theodore, Bollinger, Nancy G, Swanson-Bean, Dorothy, Wright, Ian G, Staten, Gilbert S, Thompson, Alan R, Froelich, Larry L, Jackson, William T
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetophenones - metabolism Acetophenones - pharmacology Chemistry Exact sciences and technology Humans Leukotriene B4 - antagonists & inhibitors Leukotriene B4 - metabolism Magnetic Resonance Spectroscopy Neutrophils - metabolism Noncondensed benzenic compounds Organic chemistry Preparations and properties Receptors, Immunologic - antagonists & inhibitors Receptors, Leukotriene B4 Structure-Activity Relationship Tetrazoles - chemistry Tetrazoles - metabolism Tetrazoles - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!