Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1

Lysophosphatidic acid (LPA) is a serum-borne phospholipid that activates its own G protein-coupled receptors present in numerous cell types. In addition to stimulating cell proliferation, LPA also induces cytoskeletal changes and promotes cell migration in a RhoA- and Rac-dependent manner. Whereas R...

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Veröffentlicht in:	The Journal of biological chemistry 2003-01, Vol.278 (1), p.400-406
Hauptverfasser:	Van Leeuwen, Frank N, Olivo, Cristina, Grivell, Shula, Giepmans, Ben N G, Collard, John G, Moolenaar, Wouter H
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - metabolism Animals Cell Movement - physiology Cell Size COS Cells Culture Media, Serum-Free Fibroblasts - cytology Fibroblasts - physiology Guanine Nucleotide Exchange Factors - metabolism Humans Insulin - metabolism Lysophospholipids - metabolism Mice Mice, Knockout Pertussis Toxin - metabolism Proteins - genetics Proteins - metabolism rac GTP-Binding Proteins - metabolism Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, G-Protein-Coupled Receptors, Lysophosphatidic Acid rho GTP-Binding Proteins - metabolism Signal Transduction - physiology T-Lymphoma Invasion and Metastasis-inducing Protein 1 Tumor Cells, Cultured Wortmannin
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