Ethanol's antiseizure efficacy is reduced by stress
The ability of ethanol to antagonize the electrical precipitation of seizures in incremental electroconvulsive shock paradigm was examined in groups of stressed and control mice. In stressed mice, the dose-response curve for ethanol's antiseizure efficacy was down-shifted and right-shifted rela...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1992-03, Vol.41 (3), p.663-664 |
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| container_end_page | 664 |
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| container_issue | 3 |
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| container_title | Pharmacology, biochemistry and behavior |
| container_volume | 41 |
| creator | Mastropaolo, John Novitzki, Monica R. Deutsch, Stephen I. |
| description | The ability of ethanol to antagonize the electrical precipitation of seizures in incremental electroconvulsive shock paradigm was examined in groups of stressed and control mice. In stressed mice, the dose-response curve for ethanol's antiseizure efficacy was down-shifted and right-shifted relative to controls. These data may have clinical implications with respect to the interaction between stress, ethanol, and proneness to seizures. |
| doi_str_mv | 10.1016/0091-3057(92)90390-2 |
| format | Article |
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In stressed mice, the dose-response curve for ethanol's antiseizure efficacy was down-shifted and right-shifted relative to controls. These data may have clinical implications with respect to the interaction between stress, ethanol, and proneness to seizures.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(92)90390-2</identifier><identifier>PMID: 1584849</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Drug Tolerance ; Electrocovulsive shock ; Electroshock ; Ethanol ; Ethanol - administration & dosage ; Ethanol - pharmacology ; Male ; Medical sciences ; Mice ; Neuropharmacology ; Pharmacology. 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In stressed mice, the dose-response curve for ethanol's antiseizure efficacy was down-shifted and right-shifted relative to controls. These data may have clinical implications with respect to the interaction between stress, ethanol, and proneness to seizures.</description><subject>Animals</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Drug Tolerance</subject><subject>Electrocovulsive shock</subject><subject>Electroshock</subject><subject>Ethanol</subject><subject>Ethanol - administration & dosage</subject><subject>Ethanol - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Seizure</subject><subject>Seizures - etiology</subject><subject>Seizures - prevention & control</subject><subject>Stress</subject><subject>Stress, Physiological - physiopathology</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMouq7-A4UexI9DNZ9NcxFE1g9Y8OI9ZNMpRrqtZlph_fVm7aI3Pc1hnnfe4SHkiNFLRllxRalhuaBKnxt-YagwNOdbZMJKLXLFtN4mkx9kj-wjvlJKJS_0LtllqpSlNBMiZv2La7vmDDPX9gEhfA4RMqjr4J1fZQGzCNXgocoWqwz7CIgHZKd2DcLhZk7J893s-fYhnz_dP97ezHMvC9HnZQ2eOeqZpMY4pRapuhBeUaYU9UrUkumy4MI4XdRca146Jz1LtaoCbcSUnI5n32L3PgD2dhnQQ9O4FroBreZGKlmqf0FWcJ1KRQLlCPrYIUao7VsMSxdXllG7dmrXwuxamDXcfju1PMWON_eHxRKq39AoMe1PNnuH3jV1dK0P-IMpXmpmWMKuRwySs48A0aIP0Ca1IYLvbdWFv__4AhI_kCY</recordid><startdate>19920301</startdate><enddate>19920301</enddate><creator>Mastropaolo, John</creator><creator>Novitzki, Monica R.</creator><creator>Deutsch, Stephen I.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19920301</creationdate><title>Ethanol's antiseizure efficacy is reduced by stress</title><author>Mastropaolo, John ; Novitzki, Monica R. ; Deutsch, Stephen I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-8fec1a0c14099a55b26763c501550c53f41786239a76f27728aa4c1cac5de793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Drug Tolerance</topic><topic>Electrocovulsive shock</topic><topic>Electroshock</topic><topic>Ethanol</topic><topic>Ethanol - administration & dosage</topic><topic>Ethanol - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Seizure</topic><topic>Seizures - etiology</topic><topic>Seizures - prevention & control</topic><topic>Stress</topic><topic>Stress, Physiological - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mastropaolo, John</creatorcontrib><creatorcontrib>Novitzki, Monica R.</creatorcontrib><creatorcontrib>Deutsch, Stephen I.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mastropaolo, John</au><au>Novitzki, Monica R.</au><au>Deutsch, Stephen I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ethanol's antiseizure efficacy is reduced by stress</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1992-03-01</date><risdate>1992</risdate><volume>41</volume><issue>3</issue><spage>663</spage><epage>664</epage><pages>663-664</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>The ability of ethanol to antagonize the electrical precipitation of seizures in incremental electroconvulsive shock paradigm was examined in groups of stressed and control mice. 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| fulltext | fulltext |
| identifier | ISSN: 0091-3057 |
| ispartof | Pharmacology, biochemistry and behavior, 1992-03, Vol.41 (3), p.663-664 |
| issn | 0091-3057 1873-5177 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Drug Tolerance Electrocovulsive shock Electroshock Ethanol Ethanol - administration & dosage Ethanol - pharmacology Male Medical sciences Mice Neuropharmacology Pharmacology. Drug treatments Seizure Seizures - etiology Seizures - prevention & control Stress Stress, Physiological - physiopathology |
| title | Ethanol's antiseizure efficacy is reduced by stress |
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