Radiosensitivity testing of human primary brain tumor specimens
The inherent radiosensitivity of early passage cells derived from 22 patients with tumors of glial origin has been determined using a clonogenic assay system. The mean (±SD) surviving fraction at 2 Gy was 0.37 ± 0.22 (range = 0.02–0.87). No correlation between inherent radiosensitivity and tumor cel...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 1992, Vol.23 (2), p.339-343 |
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| container_title | International journal of radiation oncology, biology, physics |
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| creator | Allalunis-Turner, M.Joan Barron, Geraldine M. Day, Rufus S. Fulton, Dorcas S. Urtasun, Raul C. |
| description | The inherent radiosensitivity of early passage cells derived from 22 patients with tumors of glial origin has been determined using a clonogenic assay system. The mean (±SD) surviving fraction at 2 Gy was 0.37 ± 0.22 (range = 0.02–0.87). No correlation between inherent radiosensitivity and tumor cell plating efficiency or intracellular glutathione was observed. Tumor cells that were both resistant to nitrosoureas and expressed the Mer+ phenotype did not differ significantly in their radiosensitivity as compared to cells that were repair deficient (Mer−) and sensitive to nitrosoureas. Initial clinical follow-up suggests that factors in addition to inherent tumor cell radiosensitivity, such as performance status and age, continue to be the most important determinants of the response of patients with primary brain tumors to radiotherapy. |
| doi_str_mv | 10.1016/0360-3016(92)90751-3 |
| format | Article |
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The mean (±SD) surviving fraction at 2 Gy was 0.37 ± 0.22 (range = 0.02–0.87). No correlation between inherent radiosensitivity and tumor cell plating efficiency or intracellular glutathione was observed. Tumor cells that were both resistant to nitrosoureas and expressed the Mer+ phenotype did not differ significantly in their radiosensitivity as compared to cells that were repair deficient (Mer−) and sensitive to nitrosoureas. Initial clinical follow-up suggests that factors in addition to inherent tumor cell radiosensitivity, such as performance status and age, continue to be the most important determinants of the response of patients with primary brain tumors to radiotherapy.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/0360-3016(92)90751-3</identifier><identifier>PMID: 1316889</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Astrocytoma - pathology ; Biological and medical sciences ; Brain Neoplasms - pathology ; Cell Survival - radiation effects ; Diseases of the nervous system ; Glioblastoma - pathology ; Glioma ; Glutathione ; Glutathione - analysis ; Humans ; In Vitro Techniques ; Medical sciences ; Mer phenotype ; Oligodendroglioma - pathology ; Predictive assays ; Radiation Tolerance ; Radiosensitivity ; Radiotherapy. Instrumental treatment. 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The mean (±SD) surviving fraction at 2 Gy was 0.37 ± 0.22 (range = 0.02–0.87). No correlation between inherent radiosensitivity and tumor cell plating efficiency or intracellular glutathione was observed. Tumor cells that were both resistant to nitrosoureas and expressed the Mer+ phenotype did not differ significantly in their radiosensitivity as compared to cells that were repair deficient (Mer−) and sensitive to nitrosoureas. Initial clinical follow-up suggests that factors in addition to inherent tumor cell radiosensitivity, such as performance status and age, continue to be the most important determinants of the response of patients with primary brain tumors to radiotherapy.</description><subject>Astrocytoma - pathology</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - pathology</subject><subject>Cell Survival - radiation effects</subject><subject>Diseases of the nervous system</subject><subject>Glioblastoma - pathology</subject><subject>Glioma</subject><subject>Glutathione</subject><subject>Glutathione - analysis</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Medical sciences</subject><subject>Mer phenotype</subject><subject>Oligodendroglioma - pathology</subject><subject>Predictive assays</subject><subject>Radiation Tolerance</subject><subject>Radiosensitivity</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Tumor Cells, Cultured - radiation effects</subject><subject>Tumor Stem Cell Assay</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMo4zj6BgpdiOiimlvbZKPI4A0GBFFwF9LkVCO9jEk7MG9vx5Zx5-ocON9_-PkQOib4kmCSXmGW4pj127mkFxJnCYnZDpoSkcmYJcn7LppukX10EMIXxpiQjE_QhDCSCiGn6OZFW9cEqINr3cq166iF0Lr6I2qK6LOrdB0tvau0X0e5166O2q5qfBSWYFzVpw7RXqHLAEfjnKG3-7vX-WO8eH54mt8uYsMZbWOeQpFTTGxqBTUZtYRZZqylxIgc5zg1JmMgU0aLwgqe0RQ0kQDYZoZyWrAZOhv-Ln3z3fUVVeWCgbLUNTRdUBmVnAkuepAPoPFNCB4KNfZXBKuNN7WRojZSlKTq15tifexk_N_lFdi_0CCqv5-Odx2MLguva-PCFuMJl0LSHrseMOhdrBx4FYyD2oB1HkyrbOP-7_EDCU-JvQ</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Allalunis-Turner, M.Joan</creator><creator>Barron, Geraldine M.</creator><creator>Day, Rufus S.</creator><creator>Fulton, Dorcas S.</creator><creator>Urtasun, Raul C.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Radiosensitivity testing of human primary brain tumor specimens</title><author>Allalunis-Turner, M.Joan ; Barron, Geraldine M. ; Day, Rufus S. ; Fulton, Dorcas S. ; Urtasun, Raul C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-46efb201d6d82c72d13d3cdd21c8b0b06cc73e9632ffd84726ea19ee0d7c242f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Astrocytoma - pathology</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - pathology</topic><topic>Cell Survival - radiation effects</topic><topic>Diseases of the nervous system</topic><topic>Glioblastoma - pathology</topic><topic>Glioma</topic><topic>Glutathione</topic><topic>Glutathione - analysis</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Medical sciences</topic><topic>Mer phenotype</topic><topic>Oligodendroglioma - pathology</topic><topic>Predictive assays</topic><topic>Radiation Tolerance</topic><topic>Radiosensitivity</topic><topic>Radiotherapy. 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| ispartof | International journal of radiation oncology, biology, physics, 1992, Vol.23 (2), p.339-343 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Astrocytoma - pathology Biological and medical sciences Brain Neoplasms - pathology Cell Survival - radiation effects Diseases of the nervous system Glioblastoma - pathology Glioma Glutathione Glutathione - analysis Humans In Vitro Techniques Medical sciences Mer phenotype Oligodendroglioma - pathology Predictive assays Radiation Tolerance Radiosensitivity Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Tumor Cells, Cultured - radiation effects Tumor Stem Cell Assay |
| title | Radiosensitivity testing of human primary brain tumor specimens |
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