Reduced Pupillary Light Responses in Mice Lacking Cryptochromes
Mice with severe degeneration of the outer retina still retain substantial photic sensitivity for pupillary responses, as well as for other light-regulated phenomena including phase shifting of circadian rhythms and suppression of pineal melatonin synthesis. Van Gelder et al discuss a study that dem...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2003-01, Vol.299 (5604), p.222-222 |
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| container_issue | 5604 |
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| creator | Van Gelder, Russell N. Wee, Raymond Lee, Janet A. Tu, Daniel C. |
| description | Mice with severe degeneration of the outer retina still retain substantial photic sensitivity for pupillary responses, as well as for other light-regulated phenomena including phase shifting of circadian rhythms and suppression of pineal melatonin synthesis. Van Gelder et al discuss a study that demonstrates that cryptochromes have an important function in the mammalian nonvisual irradiance detection pathway. |
| doi_str_mv | 10.1126/science.1079536 |
| format | Article |
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Van Gelder et al discuss a study that demonstrates that cryptochromes have an important function in the mammalian nonvisual irradiance detection pathway.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1079536</identifier><identifier>PMID: 12522242</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Animals ; Biological and medical sciences ; Brain ; Brain stimulation ; Brevia ; Circadian rhythm ; Cryptochromes ; Drosophila Proteins ; Experiments ; Eye and associated structures. Visual pathways and centers. Vision ; Eye Proteins ; Feedback (Response) ; Flavoproteins - genetics ; Flavoproteins - physiology ; Fundamental and applied biological sciences. Psychology ; Irradiance ; Light ; Mathematical functions ; Mice ; Mice, mutant strains ; Miotics - pharmacology ; Molecular Biology ; Motor Reactions ; Mutant mice ; Mutation ; Ophthalmology ; Photoreceptor Cells, Invertebrate ; Pilocarpine - pharmacology ; Pupil (Eye) ; Pupil - drug effects ; Pupil - physiology ; Receptors, G-Protein-Coupled ; Reflex, Pupillary ; Retina ; Retina - physiology ; Retinal Degeneration - genetics ; Retinal Degeneration - physiopathology ; Rodents ; Statistics ; Testing ; Trusts (Financial) ; Vertebrates: nervous system and sense organs</subject><ispartof>Science (American Association for the Advancement of Science), 2003-01, Vol.299 (5604), p.222-222</ispartof><rights>Copyright 2003 American Association for the Advancement of Science</rights><rights>2003 INIST-CNRS</rights><rights>COPYRIGHT 2003 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2003 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jan 10, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c675t-3e428c1769aeeb75a1e17341006e40a73b5e2ba65864e9bdb4b08c2a7393d14a3</citedby><cites>FETCH-LOGICAL-c675t-3e428c1769aeeb75a1e17341006e40a73b5e2ba65864e9bdb4b08c2a7393d14a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3833329$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3833329$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14470808$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12522242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Gelder, Russell N.</creatorcontrib><creatorcontrib>Wee, Raymond</creatorcontrib><creatorcontrib>Lee, Janet A.</creatorcontrib><creatorcontrib>Tu, Daniel C.</creatorcontrib><title>Reduced Pupillary Light Responses in Mice Lacking Cryptochromes</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Mice with severe degeneration of the outer retina still retain substantial photic sensitivity for pupillary responses, as well as for other light-regulated phenomena including phase shifting of circadian rhythms and suppression of pineal melatonin synthesis. Van Gelder et al discuss a study that demonstrates that cryptochromes have an important function in the mammalian nonvisual irradiance detection pathway.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain stimulation</subject><subject>Brevia</subject><subject>Circadian rhythm</subject><subject>Cryptochromes</subject><subject>Drosophila Proteins</subject><subject>Experiments</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Eye Proteins</subject><subject>Feedback (Response)</subject><subject>Flavoproteins - genetics</subject><subject>Flavoproteins - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Irradiance</subject><subject>Light</subject><subject>Mathematical functions</subject><subject>Mice</subject><subject>Mice, mutant strains</subject><subject>Miotics - pharmacology</subject><subject>Molecular Biology</subject><subject>Motor Reactions</subject><subject>Mutant mice</subject><subject>Mutation</subject><subject>Ophthalmology</subject><subject>Photoreceptor Cells, Invertebrate</subject><subject>Pilocarpine - pharmacology</subject><subject>Pupil (Eye)</subject><subject>Pupil - drug effects</subject><subject>Pupil - physiology</subject><subject>Receptors, G-Protein-Coupled</subject><subject>Reflex, Pupillary</subject><subject>Retina</subject><subject>Retina - physiology</subject><subject>Retinal Degeneration - genetics</subject><subject>Retinal Degeneration - physiopathology</subject><subject>Rodents</subject><subject>Statistics</subject><subject>Testing</subject><subject>Trusts (Financial)</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0s2LEzEYB-BBFLdWz15EBkHxsLObz0lykrVoXahW1o9ryGTezqY7ndRkBtz_3kgHl0phSw6BvE_Cm-SXZc8xOsOYlOfROugsnGEkFKflg2yCkeKFIog-zCYI0bKQSPCT7EmMa4RSTdHH2QkmnBDCyCR7dwX1YKHOvw5b17Ym3OYL11z3-RXEre8ixNx1-WdnIV8Ye-O6Jp-F223v7XXwG4hPs0cr00Z4Ns7T7MfHD99nn4rFcn45u1gUthS8LygwIi0WpTIAleAGAxaUYYRKYMgIWnEglSm5LBmoqq5YhaQlqaBojZmh0-zN7txt8L8GiL3euGghddyBH6IWRDHKJboXEqEYVkjcC7FAjPOSJfjqP7j2Q-jSbTXBlCus0tNPs9MdakwL2nUr3wdjG-ggmNZ3sHJp-UKVUjGJaeLFAZ5GDRtnD_m3ez6RHn73jRli1JffvhxNlz-Ppu_nx1I5X-zR00PU-raFBnSKxWy5x8933AYfY4CV3ga3SUHUGOm_IddjyPUY8rTj5fghQ7WB-s6PqU7g9QhMtKZdBdNZF-8cYwJJJJN7sXPr2Pvwr04lpZQo-geLlQhu</recordid><startdate>20030110</startdate><enddate>20030110</enddate><creator>Van Gelder, Russell N.</creator><creator>Wee, Raymond</creator><creator>Lee, Janet A.</creator><creator>Tu, Daniel C.</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20030110</creationdate><title>Reduced Pupillary Light Responses in Mice Lacking Cryptochromes</title><author>Van Gelder, Russell N. ; 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| ispartof | Science (American Association for the Advancement of Science), 2003-01, Vol.299 (5604), p.222-222 |
| issn | 0036-8075 1095-9203 |
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| source | Jstor Complete Legacy; MEDLINE; Science Magazine |
| subjects | Animals Biological and medical sciences Brain Brain stimulation Brevia Circadian rhythm Cryptochromes Drosophila Proteins Experiments Eye and associated structures. Visual pathways and centers. Vision Eye Proteins Feedback (Response) Flavoproteins - genetics Flavoproteins - physiology Fundamental and applied biological sciences. Psychology Irradiance Light Mathematical functions Mice Mice, mutant strains Miotics - pharmacology Molecular Biology Motor Reactions Mutant mice Mutation Ophthalmology Photoreceptor Cells, Invertebrate Pilocarpine - pharmacology Pupil (Eye) Pupil - drug effects Pupil - physiology Receptors, G-Protein-Coupled Reflex, Pupillary Retina Retina - physiology Retinal Degeneration - genetics Retinal Degeneration - physiopathology Rodents Statistics Testing Trusts (Financial) Vertebrates: nervous system and sense organs |
| title | Reduced Pupillary Light Responses in Mice Lacking Cryptochromes |
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