Corneal Neovascularization after Excimer Keratectomy Wounds in Matrilysin-Deficient Mice

Matrilysin, matrix metalloproteinase (MMP)-7, is upregulated in the corneal epithelium during wound healing after excimer keratectomy wounds. The purpose of this study was to determine the role of matrilysin in maintaining corneal avascularity during wound healing. Matrilysin-deficient mice (n = 17)...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2003-01, Vol.44 (1), p.137-144
Hauptverfasser:	Kure, Tomoko, Chang, Jin-Hong, Kato, Takuji, Hernandez-Quintela, Everardo, Ye, Hongqing, Lu, Paul Chung-Shien, Matrisian, Lynn M, Gatinel, Damien, Shapiro, Steven, Ghosheh, Faris, Azar, Dimitri T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western Collagen Type IV - metabolism Cornea - surgery Corneal Neovascularization - enzymology Corneal Neovascularization - etiology Corneal Stroma - blood supply Endothelial Growth Factors - metabolism Epithelium, Corneal - enzymology Epithelium, Corneal - pathology Female Fibroblast Growth Factor 2 - metabolism Image Processing, Computer-Assisted Intercellular Signaling Peptides and Proteins - metabolism Lasers, Excimer Lymphokines - metabolism Male Matrix Metalloproteinase 7 - deficiency Matrix Metalloproteinase 7 - physiology Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Photorefractive Keratectomy - adverse effects Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the eye and orbit Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Wound Healing
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