Species Difference in Nisoldipine Oxidation Activity in the Small Intestine

Species difference in nisoldipine oxidation activities was investigated using small intestinal microsomes of rats, guinea pigs, dogs, monkeys and humans. The oxidation activities were estimated by measuring metabolites formation (BAY o 3199 and BAY r 9425) of nisoldipine. For the preparation of smal...

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Veröffentlicht in:	DRUG METABOLISM AND PHARMACOKINETICS 2002, Vol.17 (5), p.427-436
Hauptverfasser:	Komura, Hiroshi, Yasuda, Motoko, Yoshida, Nagahiro H., Sugiyama, Yuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	CYP3A human intestinal metabolism monkey nisoldipine species difference
Online-Zugang:	Volltext
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