Intramuscular injection of AAV-GDNF results in sustained expression of transgenic GDNF, and its delivery to spinal motoneurons by retrograde transport

Adeno-associated virus (AAV) vector has been developed as an attractive gene delivery system with proven safety. Glial cell line-derived neurotrophic factor (GDNF) is proposed to be a promising therapeutic agent for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases. The purpose of...

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Veröffentlicht in:	Neuroscience research 2003, Vol.45 (1), p.33-40
Hauptverfasser:	Lu, Yan-Yan, Wang, Li-Jun, Muramatsu, Shin-ichi, Ikeguchi, Kunihiko, Fujimoto, Ken-ichi, Okada, Takashi, Mizukami, Hiroaki, Matsushita, Takashi, Hanazono, Yutaka, Kume, Akihiro, Nagatsu, Toshiharu, Ozawa, Keiya, Nakano, Imaharu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus (AAV) Animals Dependovirus - genetics Enzyme-Linked Immunosorbent Assay Gene therapy Genetic Therapy - methods Genetic Vectors - administration & dosage Glial Cell Line-Derived Neurotrophic Factor Glial cell line-derived neurotrophic factor (GDNF) Humans Immunohistochemistry Injections, Intramuscular Intramuscular injection Mice Motoneurons Motor Neurons - metabolism Muscle, Skeletal - metabolism Nerve Growth Factors - biosynthesis Nerve Growth Factors - genetics Retrograde transport Spinal Cord - cytology Spinal Cord - metabolism Time Factors Transduction, Genetic - methods Transgenes
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