Agonist-specific down-regulation of the human δ-opioid receptor

Down-regulation of the δ-opioid receptor contributes to the development of tolerance to δ-opioid receptor agonists. The involvement of the carboxy terminus of the mouse δ-opioid receptor in peptide agonist-mediated down-regulation has been established. In the present study, we examined the down-regu...

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Veröffentlicht in:	European journal of pharmacology 2003-01, Vol.459 (1), p.9-16
Hauptverfasser:	Okura, Takashi, Varga, Eva V., Hosohata, Yoshiaki, Navratilova, Edita, Cowell, Scott M., Rice, Kenner, Nagase, Hiroshi, Hruby, Victor J., Roeske, William R., Yamamura, Henry I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonist-directed trafficking Amino Acid Sequence Analgesics, Opioid - pharmacology Animals Benzamides - pharmacology Binding, Competitive - drug effects Biological and medical sciences Cell receptors Cell structures and functions CHO Cells Cricetinae Dose-Response Relationship, Drug Down-Regulation Enkephalin, D-Penicillamine (2,5)- - pharmacology Fundamental and applied biological sciences. Psychology human Humans Medical sciences Molecular and cellular biology Molecular Sequence Data Naltrexone - analogs & derivatives Naltrexone - metabolism Neuropeptide receptors Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pertussis toxin Pertussis Toxin - pharmacology Pharmacology. Drug treatments Phosphorylation Phosphorylation - drug effects Piperazines - pharmacology Radioligand Assay Receptors, Opioid, delta - agonists Receptors, Opioid, delta - genetics Receptors, Opioid, delta - metabolism Recombinant Fusion Proteins - agonists Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Sequence Deletion Tritium δ-Opioid receptor
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