Nicastrin is a resident lysosomal membrane protein

Nicastrin has been recently identified as part of the γ-secretase complex that includes presenilin and other proteins. It is involved in the degradation of amyloid precursor protein to produce β-amyloid peptides which are believed to be central to the pathophysiology of Alzheimer’s disease. Previous...

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Veröffentlicht in:	Biochemical and biophysical research communications 2003-01, Vol.300 (3), p.615-618
Hauptverfasser:	Bagshaw, Richard D, Pasternak, Stephen H, Mahuran, Don J, Callahan, John W
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease Amyloid Precursor Protein Secretases Animals Blotting, Western Cathepsin D - chemistry Electrophoresis, Gel, Two-Dimensional Electrophoresis, Polyacrylamide Gel Intra-cellular localization Intracellular Membranes - chemistry Lysosomal membrane proteins Lysosomes - chemistry Lysosomes - metabolism Membrane Glycoproteins - chemistry Membrane Proteins - chemistry Nicastrin Polyethylene Glycols - metabolism Rats Rats, Sprague-Dawley Subcellular Fractions - chemistry Tritosomes γ-Secretase
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