Experimental conduction block induced by serum from a patient with anti-GM1 antibodies
Increased titers of antibodies to GM1 ganglioside in humans are associated with lower motor neuron disease and predominantly motor neuropathy with or without conduction block. To investigate the possible mechanism of these antibodies, we injected the serum of a patient with anti‐GM1 antibodies who h...
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| Veröffentlicht in: | Annals of neurology 1992-04, Vol.31 (4), p.385-390 |
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| container_end_page | 390 |
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| container_issue | 4 |
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| container_title | Annals of neurology |
| container_volume | 31 |
| creator | Santoro, Maria Uncini, Antonino Corbo, Massimo Staugaitis, Susan M. Thomas, Florian P. Hays, Arthur P. Latov, Norman |
| description | Increased titers of antibodies to GM1 ganglioside in humans are associated with lower motor neuron disease and predominantly motor neuropathy with or without conduction block. To investigate the possible mechanism of these antibodies, we injected the serum of a patient with anti‐GM1 antibodies who had motor neuron disease and multifocal motor conduction block, into rat sciatic nerve. When injected with fresh human complement, the serum‐induced conduction block with temporal dispersion and deposits of immunoglobulin were detected at the nodes of Ranvier. Electron microscopic studies revealed demyelination in 6.5% of the fibers. After preabsorbtion with GM1, the serum had no effect, suggesting that the anti‐GM1 antibodies were responsible for the conduction abnormalities. |
| doi_str_mv | 10.1002/ana.410310407 |
| format | Article |
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To investigate the possible mechanism of these antibodies, we injected the serum of a patient with anti‐GM1 antibodies who had motor neuron disease and multifocal motor conduction block, into rat sciatic nerve. When injected with fresh human complement, the serum‐induced conduction block with temporal dispersion and deposits of immunoglobulin were detected at the nodes of Ranvier. Electron microscopic studies revealed demyelination in 6.5% of the fibers. After preabsorbtion with GM1, the serum had no effect, suggesting that the anti‐GM1 antibodies were responsible for the conduction abnormalities.</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.410310407</identifier><identifier>PMID: 1586139</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Antibodies - analysis ; Biological and medical sciences ; Blood Physiological Phenomena ; Electrophysiology ; Fluorescent Antibody Technique ; G(M1) Ganglioside - immunology ; Humans ; Male ; Medical sciences ; Microscopy, Electron ; Motor Neurons - physiology ; Nervous system involvement in other diseases. Miscellaneous ; Neural Conduction ; Neurology ; Neuromuscular Diseases - blood ; Neuromuscular Diseases - physiopathology ; Rats ; Rats, Inbred Strains ; Sciatic Nerve - pathology ; Sciatic Nerve - physiopathology</subject><ispartof>Annals of neurology, 1992-04, Vol.31 (4), p.385-390</ispartof><rights>Copyright © 1992 American Neurological Association</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4037-5230b02244f4daabcc295d8f184368664ae9b106364233cf11102a8a35b3c8973</citedby><cites>FETCH-LOGICAL-c4037-5230b02244f4daabcc295d8f184368664ae9b106364233cf11102a8a35b3c8973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.410310407$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.410310407$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5231296$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1586139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santoro, Maria</creatorcontrib><creatorcontrib>Uncini, Antonino</creatorcontrib><creatorcontrib>Corbo, Massimo</creatorcontrib><creatorcontrib>Staugaitis, Susan M.</creatorcontrib><creatorcontrib>Thomas, Florian P.</creatorcontrib><creatorcontrib>Hays, Arthur P.</creatorcontrib><creatorcontrib>Latov, Norman</creatorcontrib><title>Experimental conduction block induced by serum from a patient with anti-GM1 antibodies</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>Increased titers of antibodies to GM1 ganglioside in humans are associated with lower motor neuron disease and predominantly motor neuropathy with or without conduction block. To investigate the possible mechanism of these antibodies, we injected the serum of a patient with anti‐GM1 antibodies who had motor neuron disease and multifocal motor conduction block, into rat sciatic nerve. When injected with fresh human complement, the serum‐induced conduction block with temporal dispersion and deposits of immunoglobulin were detected at the nodes of Ranvier. Electron microscopic studies revealed demyelination in 6.5% of the fibers. After preabsorbtion with GM1, the serum had no effect, suggesting that the anti‐GM1 antibodies were responsible for the conduction abnormalities.</description><subject>Animals</subject><subject>Antibodies - analysis</subject><subject>Biological and medical sciences</subject><subject>Blood Physiological Phenomena</subject><subject>Electrophysiology</subject><subject>Fluorescent Antibody Technique</subject><subject>G(M1) Ganglioside - immunology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Motor Neurons - physiology</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neural Conduction</subject><subject>Neurology</subject><subject>Neuromuscular Diseases - blood</subject><subject>Neuromuscular Diseases - physiopathology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Sciatic Nerve - pathology</subject><subject>Sciatic Nerve - physiopathology</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1v1DAQxS0EKsuWI0ckHxC3lBnbsZPjUpVtpVIkRFtu1sRxhGk-tnaidv970u5q4cRpPJrfG897jL1DOEEA8Yl6OlEIEkGBecEWmEvMCqHKl2wBUqssR6leszcp_QaAUiMcsSPMC42yXLCbs8eNj6Hz_Ugtd0NfT24MQ8-rdnB3PDz1vubVlicfp443ceg48Q2NYZbwhzD-4tSPIVt_xedHNdTBp2P2qqE2-bf7umTXX85-nJ5nl9_WF6ery8wpkCbLhYQKhFCqUTVR5Zwo87posFBSF1or8mWFoGcbQkrXICIIKkjmlXRFaeSSfdzt3cThfvJptF1Izrct9X6YkjWilNrM2iXLdqCLQ0rRN3Yzu6a4tQj2KUc752gPOc78-_3iqep8_ZfeBTfPP-znlBy1TaTehXTAZmMoSj1jZoc9hNZv__-nXV2t_j1gf3BIo388KCneWW2kye3t1dqa8-8gbn9-tjfyD4cXmHs</recordid><startdate>199204</startdate><enddate>199204</enddate><creator>Santoro, Maria</creator><creator>Uncini, Antonino</creator><creator>Corbo, Massimo</creator><creator>Staugaitis, Susan M.</creator><creator>Thomas, Florian P.</creator><creator>Hays, Arthur P.</creator><creator>Latov, Norman</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199204</creationdate><title>Experimental conduction block induced by serum from a patient with anti-GM1 antibodies</title><author>Santoro, Maria ; Uncini, Antonino ; Corbo, Massimo ; Staugaitis, Susan M. ; Thomas, Florian P. ; Hays, Arthur P. ; Latov, Norman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4037-5230b02244f4daabcc295d8f184368664ae9b106364233cf11102a8a35b3c8973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Antibodies - analysis</topic><topic>Biological and medical sciences</topic><topic>Blood Physiological Phenomena</topic><topic>Electrophysiology</topic><topic>Fluorescent Antibody Technique</topic><topic>G(M1) Ganglioside - immunology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Motor Neurons - physiology</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neural Conduction</topic><topic>Neurology</topic><topic>Neuromuscular Diseases - blood</topic><topic>Neuromuscular Diseases - physiopathology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Sciatic Nerve - pathology</topic><topic>Sciatic Nerve - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santoro, Maria</creatorcontrib><creatorcontrib>Uncini, Antonino</creatorcontrib><creatorcontrib>Corbo, Massimo</creatorcontrib><creatorcontrib>Staugaitis, Susan M.</creatorcontrib><creatorcontrib>Thomas, Florian P.</creatorcontrib><creatorcontrib>Hays, Arthur P.</creatorcontrib><creatorcontrib>Latov, Norman</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santoro, Maria</au><au>Uncini, Antonino</au><au>Corbo, Massimo</au><au>Staugaitis, Susan M.</au><au>Thomas, Florian P.</au><au>Hays, Arthur P.</au><au>Latov, Norman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental conduction block induced by serum from a patient with anti-GM1 antibodies</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>1992-04</date><risdate>1992</risdate><volume>31</volume><issue>4</issue><spage>385</spage><epage>390</epage><pages>385-390</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>Increased titers of antibodies to GM1 ganglioside in humans are associated with lower motor neuron disease and predominantly motor neuropathy with or without conduction block. To investigate the possible mechanism of these antibodies, we injected the serum of a patient with anti‐GM1 antibodies who had motor neuron disease and multifocal motor conduction block, into rat sciatic nerve. When injected with fresh human complement, the serum‐induced conduction block with temporal dispersion and deposits of immunoglobulin were detected at the nodes of Ranvier. Electron microscopic studies revealed demyelination in 6.5% of the fibers. After preabsorbtion with GM1, the serum had no effect, suggesting that the anti‐GM1 antibodies were responsible for the conduction abnormalities.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>1586139</pmid><doi>10.1002/ana.410310407</doi><tpages>6</tpages></addata></record> |
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| language | eng |
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| subjects | Animals Antibodies - analysis Biological and medical sciences Blood Physiological Phenomena Electrophysiology Fluorescent Antibody Technique G(M1) Ganglioside - immunology Humans Male Medical sciences Microscopy, Electron Motor Neurons - physiology Nervous system involvement in other diseases. Miscellaneous Neural Conduction Neurology Neuromuscular Diseases - blood Neuromuscular Diseases - physiopathology Rats Rats, Inbred Strains Sciatic Nerve - pathology Sciatic Nerve - physiopathology |
| title | Experimental conduction block induced by serum from a patient with anti-GM1 antibodies |
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