Positron emission mammography: initial clinical results
Evaluation of high-risk mammograms represents an enormous clinical challenge. Functional breast imaging coupled with mammography (positron emission mammography [PEM]) could improve imaging of such lesions. A prospective study was performed using PEM in women scheduled for stereotactic breast biopsy....
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| Veröffentlicht in: | Annals of surgical oncology 2003-01, Vol.10 (1), p.86-91 |
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| container_title | Annals of surgical oncology |
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| creator | Levine, Edward A Freimanis, Rita I Perrier, Nancy D Morton, Kathryn Lesko, Nadia M Bergman, Simon Geisinger, Kim R Williams, Rodney C Sharpe, Connie Zavarzin, Valera Weinberg, Irving N Stepanov, Pavel Y Beylin, David Lauckner, Kathryn Doss, Mohan Lovelace, Judy Adler, Lee P |
| description | Evaluation of high-risk mammograms represents an enormous clinical challenge. Functional breast imaging coupled with mammography (positron emission mammography [PEM]) could improve imaging of such lesions. A prospective study was performed using PEM in women scheduled for stereotactic breast biopsy.
Patients were recruited from the surgical clinic. Patients were injected with 10 mCi of 2-[18F] fluorodeoxyglucose. One hour later, patients were positioned on the stereotactic biopsy table, imaged with a PEM scanner, and a stereotactic biopsy was performed. Imaging was reviewed and compared with pathologic results.
There were 18 lesions in 16 patients. PEM images were analyzed by drawing a region of interest at the biopsy site and comparing the count density in the region of interest with the background. A lesion-to-background ratio >2.5 appeared to be a robust indicator of malignancy and yielded a sensitivity of 86%, specificity of 91%, and overall diagnostic accuracy of 89%. No adverse events were associated with the PEM imaging.
The data show that PEM is safe, feasible, and has an encouraging accuracy rate in this initial experience. Lesion-to-background ratios >2.5 were found to be a useful threshold value for identifying positive (malignant) results. This study supports the further development of PEM. |
| doi_str_mv | 10.1245/aso.2003.03.047 |
| format | Article |
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Patients were recruited from the surgical clinic. Patients were injected with 10 mCi of 2-[18F] fluorodeoxyglucose. One hour later, patients were positioned on the stereotactic biopsy table, imaged with a PEM scanner, and a stereotactic biopsy was performed. Imaging was reviewed and compared with pathologic results.
There were 18 lesions in 16 patients. PEM images were analyzed by drawing a region of interest at the biopsy site and comparing the count density in the region of interest with the background. A lesion-to-background ratio >2.5 appeared to be a robust indicator of malignancy and yielded a sensitivity of 86%, specificity of 91%, and overall diagnostic accuracy of 89%. No adverse events were associated with the PEM imaging.
The data show that PEM is safe, feasible, and has an encouraging accuracy rate in this initial experience. Lesion-to-background ratios >2.5 were found to be a useful threshold value for identifying positive (malignant) results. This study supports the further development of PEM.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/aso.2003.03.047</identifier><identifier>PMID: 12513966</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biopsy, Needle - methods ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - pathology ; Female ; Humans ; Image Processing, Computer-Assisted ; Mammography - methods ; Middle Aged ; Pilot Projects ; Prospective Studies ; Tomography, Emission-Computed</subject><ispartof>Annals of surgical oncology, 2003-01, Vol.10 (1), p.86-91</ispartof><rights>The Society of Surgical Oncology, Inc. 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-7cd3b74a080798b935928242a52b904f5202f79bc9487cfb63d6cd235fe512f03</citedby><cites>FETCH-LOGICAL-c386t-7cd3b74a080798b935928242a52b904f5202f79bc9487cfb63d6cd235fe512f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12513966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levine, Edward A</creatorcontrib><creatorcontrib>Freimanis, Rita I</creatorcontrib><creatorcontrib>Perrier, Nancy D</creatorcontrib><creatorcontrib>Morton, Kathryn</creatorcontrib><creatorcontrib>Lesko, Nadia M</creatorcontrib><creatorcontrib>Bergman, Simon</creatorcontrib><creatorcontrib>Geisinger, Kim R</creatorcontrib><creatorcontrib>Williams, Rodney C</creatorcontrib><creatorcontrib>Sharpe, Connie</creatorcontrib><creatorcontrib>Zavarzin, Valera</creatorcontrib><creatorcontrib>Weinberg, Irving N</creatorcontrib><creatorcontrib>Stepanov, Pavel Y</creatorcontrib><creatorcontrib>Beylin, David</creatorcontrib><creatorcontrib>Lauckner, Kathryn</creatorcontrib><creatorcontrib>Doss, Mohan</creatorcontrib><creatorcontrib>Lovelace, Judy</creatorcontrib><creatorcontrib>Adler, Lee P</creatorcontrib><title>Positron emission mammography: initial clinical results</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><description>Evaluation of high-risk mammograms represents an enormous clinical challenge. Functional breast imaging coupled with mammography (positron emission mammography [PEM]) could improve imaging of such lesions. A prospective study was performed using PEM in women scheduled for stereotactic breast biopsy.
Patients were recruited from the surgical clinic. Patients were injected with 10 mCi of 2-[18F] fluorodeoxyglucose. One hour later, patients were positioned on the stereotactic biopsy table, imaged with a PEM scanner, and a stereotactic biopsy was performed. Imaging was reviewed and compared with pathologic results.
There were 18 lesions in 16 patients. PEM images were analyzed by drawing a region of interest at the biopsy site and comparing the count density in the region of interest with the background. A lesion-to-background ratio >2.5 appeared to be a robust indicator of malignancy and yielded a sensitivity of 86%, specificity of 91%, and overall diagnostic accuracy of 89%. No adverse events were associated with the PEM imaging.
The data show that PEM is safe, feasible, and has an encouraging accuracy rate in this initial experience. Lesion-to-background ratios >2.5 were found to be a useful threshold value for identifying positive (malignant) results. This study supports the further development of PEM.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biopsy, Needle - methods</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Mammography - methods</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>Prospective Studies</subject><subject>Tomography, Emission-Computed</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkMtLAzEYxIMotlbP3qR48LZt3g9vpfiCQgX1HLLZRLfsbmqye-h_bxYLgjDwzeH3DcMAcI3gAmHKliaFBYaQLEZRcQKmiBFaUC7RafaQy0JhzibgIqUdhEgQyM7BBGGGiOJ8CsRrSHUfQzd3bZ1SnU1r2jZ8RrP_OtzP667ua9PMbZOdzSa6NDR9ugRn3jTJXR3vDHw8Pryvn4vN9ullvdoUlkjeF8JWpBTUQAmFkqUiTGGJKTYMlwpSzzDEXqjSKiqF9SUnFbcVJsw7hrCHZAbufnP3MXwPLvU617SuaUznwpC0wDlTMp7B23_gLgyxy900xhBxJJHM0PIXsjGkFJ3X-1i3Jh40gnocVK_etnocVI-iIn_cHGOHsnXVH39ckPwAKu1vlw</recordid><startdate>200301</startdate><enddate>200301</enddate><creator>Levine, Edward A</creator><creator>Freimanis, Rita I</creator><creator>Perrier, Nancy D</creator><creator>Morton, Kathryn</creator><creator>Lesko, Nadia M</creator><creator>Bergman, Simon</creator><creator>Geisinger, Kim R</creator><creator>Williams, Rodney C</creator><creator>Sharpe, Connie</creator><creator>Zavarzin, Valera</creator><creator>Weinberg, Irving N</creator><creator>Stepanov, Pavel Y</creator><creator>Beylin, David</creator><creator>Lauckner, Kathryn</creator><creator>Doss, Mohan</creator><creator>Lovelace, Judy</creator><creator>Adler, Lee P</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>200301</creationdate><title>Positron emission mammography: initial clinical results</title><author>Levine, Edward A ; Freimanis, Rita I ; Perrier, Nancy D ; Morton, Kathryn ; Lesko, Nadia M ; Bergman, Simon ; Geisinger, Kim R ; Williams, Rodney C ; Sharpe, Connie ; Zavarzin, Valera ; Weinberg, Irving N ; Stepanov, Pavel Y ; Beylin, David ; Lauckner, Kathryn ; Doss, Mohan ; Lovelace, Judy ; Adler, Lee P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-7cd3b74a080798b935928242a52b904f5202f79bc9487cfb63d6cd235fe512f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biopsy, Needle - methods</topic><topic>Breast Neoplasms - diagnostic imaging</topic><topic>Breast Neoplasms - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Mammography - methods</topic><topic>Middle Aged</topic><topic>Pilot Projects</topic><topic>Prospective Studies</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levine, Edward A</creatorcontrib><creatorcontrib>Freimanis, Rita I</creatorcontrib><creatorcontrib>Perrier, Nancy D</creatorcontrib><creatorcontrib>Morton, Kathryn</creatorcontrib><creatorcontrib>Lesko, Nadia M</creatorcontrib><creatorcontrib>Bergman, Simon</creatorcontrib><creatorcontrib>Geisinger, Kim R</creatorcontrib><creatorcontrib>Williams, Rodney C</creatorcontrib><creatorcontrib>Sharpe, Connie</creatorcontrib><creatorcontrib>Zavarzin, Valera</creatorcontrib><creatorcontrib>Weinberg, Irving N</creatorcontrib><creatorcontrib>Stepanov, Pavel Y</creatorcontrib><creatorcontrib>Beylin, David</creatorcontrib><creatorcontrib>Lauckner, Kathryn</creatorcontrib><creatorcontrib>Doss, Mohan</creatorcontrib><creatorcontrib>Lovelace, Judy</creatorcontrib><creatorcontrib>Adler, Lee P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levine, Edward A</au><au>Freimanis, Rita I</au><au>Perrier, Nancy D</au><au>Morton, Kathryn</au><au>Lesko, Nadia M</au><au>Bergman, Simon</au><au>Geisinger, Kim R</au><au>Williams, Rodney C</au><au>Sharpe, Connie</au><au>Zavarzin, Valera</au><au>Weinberg, Irving N</au><au>Stepanov, Pavel Y</au><au>Beylin, David</au><au>Lauckner, Kathryn</au><au>Doss, Mohan</au><au>Lovelace, Judy</au><au>Adler, Lee P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Positron emission mammography: initial clinical results</atitle><jtitle>Annals of surgical oncology</jtitle><addtitle>Ann Surg Oncol</addtitle><date>2003-01</date><risdate>2003</risdate><volume>10</volume><issue>1</issue><spage>86</spage><epage>91</epage><pages>86-91</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Evaluation of high-risk mammograms represents an enormous clinical challenge. Functional breast imaging coupled with mammography (positron emission mammography [PEM]) could improve imaging of such lesions. A prospective study was performed using PEM in women scheduled for stereotactic breast biopsy.
Patients were recruited from the surgical clinic. Patients were injected with 10 mCi of 2-[18F] fluorodeoxyglucose. One hour later, patients were positioned on the stereotactic biopsy table, imaged with a PEM scanner, and a stereotactic biopsy was performed. Imaging was reviewed and compared with pathologic results.
There were 18 lesions in 16 patients. PEM images were analyzed by drawing a region of interest at the biopsy site and comparing the count density in the region of interest with the background. A lesion-to-background ratio >2.5 appeared to be a robust indicator of malignancy and yielded a sensitivity of 86%, specificity of 91%, and overall diagnostic accuracy of 89%. No adverse events were associated with the PEM imaging.
The data show that PEM is safe, feasible, and has an encouraging accuracy rate in this initial experience. Lesion-to-background ratios >2.5 were found to be a useful threshold value for identifying positive (malignant) results. This study supports the further development of PEM.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>12513966</pmid><doi>10.1245/aso.2003.03.047</doi><tpages>6</tpages></addata></record> |
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| ispartof | Annals of surgical oncology, 2003-01, Vol.10 (1), p.86-91 |
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| language | eng |
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| subjects | Adult Aged Aged, 80 and over Biopsy, Needle - methods Breast Neoplasms - diagnostic imaging Breast Neoplasms - pathology Female Humans Image Processing, Computer-Assisted Mammography - methods Middle Aged Pilot Projects Prospective Studies Tomography, Emission-Computed |
| title | Positron emission mammography: initial clinical results |
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