A Pilot Study of Cidofovir in Patients with Kaposi Sarcoma
A clinical trial was conducted to test the activity of cidofovir (CDV), a drug with in vitro activity against Kaposi sarcoma (KS)–associated herpesvirus (KSHV), in KS. Five patients with human immunodeficiency virus–associated KS (4 receiving antiretroviral therapy) and 2 patients with classical KS...
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| Veröffentlicht in: | The Journal of infectious diseases 2003-01, Vol.187 (1), p.149-153 |
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| container_title | The Journal of infectious diseases |
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| creator | Little, Richard F. Merced-Galindez, Florentino Staskus, Katherine Whitby, Denise Aoki, Yoshiyasu Humphrey, Rachel Pluda, James M. Marshall, Vickie Walters, Michael Welles, Lauri Rodriguez-Chavez, Isaac R. Pittaluga, Stefania Tosato, Giovanna Yarchoan, Robert |
| description | A clinical trial was conducted to test the activity of cidofovir (CDV), a drug with in vitro activity against Kaposi sarcoma (KS)–associated herpesvirus (KSHV), in KS. Five patients with human immunodeficiency virus–associated KS (4 receiving antiretroviral therapy) and 2 patients with classical KS were administered CDV (5 mg/kg/dose) weekly for 2 weeks and then every other week. All 7 patients had progression of their KS at a median of 8.1 weeks (range, 5–27 weeks). Skin biopsy specimens of KS lesions showed no change in expression of latent or early lytic genes, but, in the 1 assessable patient, there was decreased expression of a late lytic gene. There was no decrease in the virus load of KSHV in peripheral blood mononuclear cells. This study does not provide proof of principle for the treatment of KS with CDV. However, it remains possible that antiherpesvirus therapy can be developed for herpes-induced tumors |
| doi_str_mv | 10.1086/346159 |
| format | Article |
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Five patients with human immunodeficiency virus–associated KS (4 receiving antiretroviral therapy) and 2 patients with classical KS were administered CDV (5 mg/kg/dose) weekly for 2 weeks and then every other week. All 7 patients had progression of their KS at a median of 8.1 weeks (range, 5–27 weeks). Skin biopsy specimens of KS lesions showed no change in expression of latent or early lytic genes, but, in the 1 assessable patient, there was decreased expression of a late lytic gene. There was no decrease in the virus load of KSHV in peripheral blood mononuclear cells. This study does not provide proof of principle for the treatment of KS with CDV. However, it remains possible that antiherpesvirus therapy can be developed for herpes-induced tumors</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/346159</identifier><identifier>PMID: 12508160</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Aged ; AIDS ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiretrovirals ; Antiviral agents ; Antiviral Agents - therapeutic use ; Antivirals ; Biological and medical sciences ; Biopsies ; Cytosine - analogs & derivatives ; Cytosine - therapeutic use ; HIV ; HIV/AIDS ; Human herpesvirus 8 ; Humans ; Interleukin-6 - blood ; Kaposi sarcoma ; Lesions ; Male ; Medical sciences ; Middle Aged ; Organophosphonates ; Organophosphorus Compounds - therapeutic use ; Pharmacology. Drug treatments ; Pilot Projects ; Sarcoma, Kaposi - drug therapy ; Sarcoma, Kaposi - pathology ; Sarcoma, Kaposi - virology ; Skin - pathology ; Tumors ; Viral Load ; Viruses</subject><ispartof>The Journal of infectious diseases, 2003-01, Vol.187 (1), p.149-153</ispartof><rights>Copyright 2003 Infectious Diseases Society of America</rights><rights>2003 by the Infectious Diseases Society of America 2003</rights><rights>2003 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Jan 1, 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-b95bfef1168763b83c545d2dd1d2ed6946846b77433434180b21e35589c98a7c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30085743$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30085743$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,4024,27923,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14461790$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12508160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Little, Richard F.</creatorcontrib><creatorcontrib>Merced-Galindez, Florentino</creatorcontrib><creatorcontrib>Staskus, Katherine</creatorcontrib><creatorcontrib>Whitby, Denise</creatorcontrib><creatorcontrib>Aoki, Yoshiyasu</creatorcontrib><creatorcontrib>Humphrey, Rachel</creatorcontrib><creatorcontrib>Pluda, James M.</creatorcontrib><creatorcontrib>Marshall, Vickie</creatorcontrib><creatorcontrib>Walters, Michael</creatorcontrib><creatorcontrib>Welles, Lauri</creatorcontrib><creatorcontrib>Rodriguez-Chavez, Isaac R.</creatorcontrib><creatorcontrib>Pittaluga, Stefania</creatorcontrib><creatorcontrib>Tosato, Giovanna</creatorcontrib><creatorcontrib>Yarchoan, Robert</creatorcontrib><title>A Pilot Study of Cidofovir in Patients with Kaposi Sarcoma</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>A clinical trial was conducted to test the activity of cidofovir (CDV), a drug with in vitro activity against Kaposi sarcoma (KS)–associated herpesvirus (KSHV), in KS. Five patients with human immunodeficiency virus–associated KS (4 receiving antiretroviral therapy) and 2 patients with classical KS were administered CDV (5 mg/kg/dose) weekly for 2 weeks and then every other week. All 7 patients had progression of their KS at a median of 8.1 weeks (range, 5–27 weeks). Skin biopsy specimens of KS lesions showed no change in expression of latent or early lytic genes, but, in the 1 assessable patient, there was decreased expression of a late lytic gene. There was no decrease in the virus load of KSHV in peripheral blood mononuclear cells. This study does not provide proof of principle for the treatment of KS with CDV. However, it remains possible that antiherpesvirus therapy can be developed for herpes-induced tumors</description><subject>Adult</subject><subject>Aged</subject><subject>AIDS</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiretrovirals</subject><subject>Antiviral agents</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Antivirals</subject><subject>Biological and medical sciences</subject><subject>Biopsies</subject><subject>Cytosine - analogs & derivatives</subject><subject>Cytosine - therapeutic use</subject><subject>HIV</subject><subject>HIV/AIDS</subject><subject>Human herpesvirus 8</subject><subject>Humans</subject><subject>Interleukin-6 - blood</subject><subject>Kaposi sarcoma</subject><subject>Lesions</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Organophosphonates</subject><subject>Organophosphorus Compounds - therapeutic use</subject><subject>Pharmacology. Drug treatments</subject><subject>Pilot Projects</subject><subject>Sarcoma, Kaposi - drug therapy</subject><subject>Sarcoma, Kaposi - pathology</subject><subject>Sarcoma, Kaposi - virology</subject><subject>Skin - pathology</subject><subject>Tumors</subject><subject>Viral Load</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0FtrFDEABeAgil2r_QctUdC3qblf-lYW20oLXVpLxZeQyWQw29nJmmTU_ntnmaULgviUh_PlhBwADjA6xkiJj5QJzPUzMMOcykoITJ-DGUKEVFhpvQde5bxECDEq5EuwhwlHCgs0AyencBG6WOBtGZpHGFs4D01s48-QYOjhwpbg-5Lhr1C-w0u7jjnAW5tcXNnX4EVru-zfbM99cHf26cv8orq6Pv88P72qHFO4VLXmdetbjIWSgtaKOs54Q5oGN8Q3QjOhmKilZJQyyrBCNcGecq6008pKR_fBh6l3neKPwediViE733W293HIRhI98vH-_yBWSnCpxQjf_QWXcUj9-AlDCFWaYU12bS7FnJNvzTqFlU2PBiOz2dxMm4_waNs21Cvf7Nh25BG83wKbne3aZHsX8s6xsUfqjXs7uTis__3Y4WSWucT0pChCajPBmFdTHnLxv59ymx6MkFRyc_H1mzmj94vLG3FubugfPSCnFQ</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>Little, Richard F.</creator><creator>Merced-Galindez, Florentino</creator><creator>Staskus, Katherine</creator><creator>Whitby, Denise</creator><creator>Aoki, Yoshiyasu</creator><creator>Humphrey, Rachel</creator><creator>Pluda, James M.</creator><creator>Marshall, Vickie</creator><creator>Walters, Michael</creator><creator>Welles, Lauri</creator><creator>Rodriguez-Chavez, Isaac R.</creator><creator>Pittaluga, Stefania</creator><creator>Tosato, Giovanna</creator><creator>Yarchoan, Robert</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20030101</creationdate><title>A Pilot Study of Cidofovir in Patients with Kaposi Sarcoma</title><author>Little, Richard F. ; Merced-Galindez, Florentino ; Staskus, Katherine ; Whitby, Denise ; Aoki, Yoshiyasu ; Humphrey, Rachel ; Pluda, James M. ; Marshall, Vickie ; Walters, Michael ; Welles, Lauri ; Rodriguez-Chavez, Isaac R. ; Pittaluga, Stefania ; Tosato, Giovanna ; Yarchoan, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-b95bfef1168763b83c545d2dd1d2ed6946846b77433434180b21e35589c98a7c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Aged</topic><topic>AIDS</topic><topic>Antibiotics. 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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Aged AIDS Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretrovirals Antiviral agents Antiviral Agents - therapeutic use Antivirals Biological and medical sciences Biopsies Cytosine - analogs & derivatives Cytosine - therapeutic use HIV HIV/AIDS Human herpesvirus 8 Humans Interleukin-6 - blood Kaposi sarcoma Lesions Male Medical sciences Middle Aged Organophosphonates Organophosphorus Compounds - therapeutic use Pharmacology. Drug treatments Pilot Projects Sarcoma, Kaposi - drug therapy Sarcoma, Kaposi - pathology Sarcoma, Kaposi - virology Skin - pathology Tumors Viral Load Viruses |
| title | A Pilot Study of Cidofovir in Patients with Kaposi Sarcoma |
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