A Highly Regioselective Synthesis of Polysubstituted Naphthalene Derivatives through Gallium Trichloride Catalyzed Alkyne-Aldehyde Coupling

A convenient synthesis of polysubstituted naphthalenes 3 involves the gallium trichloride catalyzed coupling of aromatic alkynes 1 and phenyl acetaldehydes or ketones 2 in dichloromethane. The reaction is highly regioselective.

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Veröffentlicht in:	Angewandte Chemie International Edition 2002-06, Vol.41 (12), p.2138-2141
Hauptverfasser:	Viswanathan, Ganapathy S., Wang, Mingwen, Li, Chao-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	aldehydes Aldehydes - chemistry alkynes Alkynes - chemistry Catalysis Chlorides - chemistry gallium Gallium - chemistry Molecular Structure naphthalenes Naphthols - chemistry Solvents - chemistry Stereoisomerism synthetic methods Temperature
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creator	Viswanathan, Ganapathy S. Wang, Mingwen Li, Chao-Jun
description	A convenient synthesis of polysubstituted naphthalenes 3 involves the gallium trichloride catalyzed coupling of aromatic alkynes 1 and phenyl acetaldehydes or ketones 2 in dichloromethane. The reaction is highly regioselective.
doi_str_mv	10.1002/1521-3773(20020617)41:12<2138::AID-ANIE2138>3.0.CO;2-T
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subjects	aldehydes Aldehydes - chemistry alkynes Alkynes - chemistry Catalysis Chlorides - chemistry gallium Gallium - chemistry Molecular Structure naphthalenes Naphthols - chemistry Solvents - chemistry Stereoisomerism synthetic methods Temperature
title	A Highly Regioselective Synthesis of Polysubstituted Naphthalene Derivatives through Gallium Trichloride Catalyzed Alkyne-Aldehyde Coupling
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