Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production

Under steady-state conditions, internalization of self-antigens embodied in apoptotic cells by dendritic cells (DCs) resident in peripheral tissue followed by DC migration and presentation of self-peptides to T cells in secondary lymphoid organs are key steps for induction and maintenance of periphe...

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Veröffentlicht in:	Blood 2003-01, Vol.101 (2), p.611-620
Hauptverfasser:	Morelli, Adrian E., Larregina, Adriana T., Shufesky, William J., Zahorchak, Alan F., Logar, Alison J., Papworth, Glenn D., Wang, Zhiliang, Watkins, Simon C., Falo, Louis D., Thomson, Angus W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Animals Apoptosis - immunology Biological and medical sciences Complement C3b - immunology Complement C3b - metabolism Cytokines - biosynthesis Cytokines - genetics Dendritic Cells - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Immunobiology Integrin alphaXbeta2 - immunology Leukocytes Macrophage-1 Antigen - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Organs and cells involved in the immune response Phagocytosis - immunology Receptors, Complement - immunology RNA Stability RNA, Messenger - biosynthesis Spleen - cytology Spleen - immunology
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