LANOMYCIN AND GLUCOLANOMYCIN, ANTIFUNGAL AGENTS PRODUCED BY Pycnidiophora dispersa: I. DISCOVERY, ISOLATION AND BIOLOGICAL ACTIVITY
The antifungal agents lanomycin and glucolanomycin were isolated from Pycnidiophora dispersa. The compounds were active against species of Candida and dermatophytes but were inactive against Aspergillus fumigatus and Gram-positive and Gram-negative bacteria. The compounds inhibited the cytochrome P-...
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| Veröffentlicht in: | Journal of antibiotics 1992/03/25, Vol.45(3), pp.306-312 |
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| container_end_page | 312 |
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| container_issue | 3 |
| container_start_page | 306 |
| container_title | Journal of antibiotics |
| container_volume | 45 |
| creator | O'SULLIVAN, JOSEPH PHILLIPSON, DOUGLAS W. KIRSCH, DONALD R. FISHER, SUSAN M. LAI, MARGARET H. TREJO, WILLIAM H. |
| description | The antifungal agents lanomycin and glucolanomycin were isolated from Pycnidiophora dispersa. The compounds were active against species of Candida and dermatophytes but were inactive against Aspergillus fumigatus and Gram-positive and Gram-negative bacteria. The compounds inhibited the cytochrome P-450 enzyme lanosterol 14α-demethylase, and are believed, therefore, to have a mode of action similar to the azole and bis-triazole class of antifungal agents. |
| doi_str_mv | 10.7164/antibiotics.45.306 |
| format | Article |
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DISCOVERY, ISOLATION AND BIOLOGICAL ACTIVITY</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><creator>O'SULLIVAN, JOSEPH ; PHILLIPSON, DOUGLAS W. ; KIRSCH, DONALD R. ; FISHER, SUSAN M. ; LAI, MARGARET H. ; TREJO, WILLIAM H.</creator><creatorcontrib>O'SULLIVAN, JOSEPH ; PHILLIPSON, DOUGLAS W. ; KIRSCH, DONALD R. ; FISHER, SUSAN M. ; LAI, MARGARET H. ; TREJO, WILLIAM H.</creatorcontrib><description>The antifungal agents lanomycin and glucolanomycin were isolated from Pycnidiophora dispersa. The compounds were active against species of Candida and dermatophytes but were inactive against Aspergillus fumigatus and Gram-positive and Gram-negative bacteria. The compounds inhibited the cytochrome P-450 enzyme lanosterol 14α-demethylase, and are believed, therefore, to have a mode of action similar to the azole and bis-triazole class of antifungal agents.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.45.306</identifier><identifier>PMID: 1577658</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Aminoglycosides ; Animals ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antibiotics (antibacterial agents, antifungal agents) ; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents ; Antifungal Agents - isolation & purification ; Antifungal Agents - pharmacology ; Applied microbiology ; Ascomycota - metabolism ; Bacteria - drug effects ; Biological and medical sciences ; Candida ; Candida - drug effects ; Ergosterol - biosynthesis ; Female ; Fermentation ; Fundamental and applied biological sciences. Psychology ; Mice ; Microbiology ; Pyrans - isolation & purification ; Pyrans - pharmacology</subject><ispartof>The Journal of Antibiotics, 1992/03/25, Vol.45(3), pp.306-312</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4516-b7c3e709fdfe89da6aceb7e9e6bd7acd577affc4d187d9dde2c9678564677b783</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5548089$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1577658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'SULLIVAN, JOSEPH</creatorcontrib><creatorcontrib>PHILLIPSON, DOUGLAS W.</creatorcontrib><creatorcontrib>KIRSCH, DONALD R.</creatorcontrib><creatorcontrib>FISHER, SUSAN M.</creatorcontrib><creatorcontrib>LAI, MARGARET H.</creatorcontrib><creatorcontrib>TREJO, WILLIAM H.</creatorcontrib><title>LANOMYCIN AND GLUCOLANOMYCIN, ANTIFUNGAL AGENTS PRODUCED BY Pycnidiophora dispersa: I. DISCOVERY, ISOLATION AND BIOLOGICAL ACTIVITY</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>The antifungal agents lanomycin and glucolanomycin were isolated from Pycnidiophora dispersa. The compounds were active against species of Candida and dermatophytes but were inactive against Aspergillus fumigatus and Gram-positive and Gram-negative bacteria. The compounds inhibited the cytochrome P-450 enzyme lanosterol 14α-demethylase, and are believed, therefore, to have a mode of action similar to the azole and bis-triazole class of antifungal agents.</description><subject>Aminoglycosides</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics (antibacterial agents, antifungal agents)</subject><subject>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</subject><subject>Antifungal Agents - isolation & purification</subject><subject>Antifungal Agents - pharmacology</subject><subject>Applied microbiology</subject><subject>Ascomycota - metabolism</subject><subject>Bacteria - drug effects</subject><subject>Biological and medical sciences</subject><subject>Candida</subject><subject>Candida - drug effects</subject><subject>Ergosterol - biosynthesis</subject><subject>Female</subject><subject>Fermentation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Pyrans - isolation & purification</subject><subject>Pyrans - pharmacology</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9P2zAYxq1pCDrYF5g0KYdpp6XYseM_x5CWUhFSxNoDJ8uxHTBKk2K3h377BVJ13LjY0vv83vd59ADwA8ExQ5RcqnbrKtdtnQ5jko4xpF_ACHGOYkSo-ApGECYo5jyBZ-BbCC8QYoYZPwWnKGWMpnwEHoqsXNw95vMyyspJNCtW-eI4-tPPlvPrVTnLiiibTcvl3-j-YTFZ5dNJdPUY3e9164zrNs-dV5FxYWN9UBfgpFZNsN8P_zlYXU-X-U1cLGbzPCtiTVJE44ppbBkUtaktF0ZRpW3FrLC0Mkxp0ydUda2JQZwZYYxNtKCMp5RQxirG8Tn4Pdzd-O51Z8NWrl3QtmlUa7tdkCwRCWdYfAoiijmmkPRgMoDadyF4W8uNd2vl9xJB-da4_NC4JKnsG--Xfh6u76q1Nf9Xhop7_ddBV0Grpvaq1S4csTQlHPK3kLcD9hK26skedeV7s8Z-dEaC8nf34elDHCn9rLy0Lf4HLsqjpA</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>O'SULLIVAN, JOSEPH</creator><creator>PHILLIPSON, DOUGLAS W.</creator><creator>KIRSCH, DONALD R.</creator><creator>FISHER, SUSAN M.</creator><creator>LAI, MARGARET H.</creator><creator>TREJO, WILLIAM H.</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>LANOMYCIN AND GLUCOLANOMYCIN, ANTIFUNGAL AGENTS PRODUCED BY Pycnidiophora dispersa</title><author>O'SULLIVAN, JOSEPH ; PHILLIPSON, DOUGLAS W. ; KIRSCH, DONALD R. ; FISHER, SUSAN M. ; LAI, MARGARET H. ; TREJO, WILLIAM H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4516-b7c3e709fdfe89da6aceb7e9e6bd7acd577affc4d187d9dde2c9678564677b783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Aminoglycosides</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics (antibacterial agents, antifungal agents)</topic><topic>Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents</topic><topic>Antifungal Agents - isolation & purification</topic><topic>Antifungal Agents - pharmacology</topic><topic>Applied microbiology</topic><topic>Ascomycota - metabolism</topic><topic>Bacteria - drug effects</topic><topic>Biological and medical sciences</topic><topic>Candida</topic><topic>Candida - drug effects</topic><topic>Ergosterol - biosynthesis</topic><topic>Female</topic><topic>Fermentation</topic><topic>Fundamental and applied biological sciences. 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DISCOVERY, ISOLATION AND BIOLOGICAL ACTIVITY</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1992</date><risdate>1992</risdate><volume>45</volume><issue>3</issue><spage>306</spage><epage>312</epage><pages>306-312</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>The antifungal agents lanomycin and glucolanomycin were isolated from Pycnidiophora dispersa. The compounds were active against species of Candida and dermatophytes but were inactive against Aspergillus fumigatus and Gram-positive and Gram-negative bacteria. The compounds inhibited the cytochrome P-450 enzyme lanosterol 14α-demethylase, and are believed, therefore, to have a mode of action similar to the azole and bis-triazole class of antifungal agents.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>1577658</pmid><doi>10.7164/antibiotics.45.306</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of Antibiotics, 1992/03/25, Vol.45(3), pp.306-312 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72928739 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Aminoglycosides Animals Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics (antibacterial agents, antifungal agents) Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Applied microbiology Ascomycota - metabolism Bacteria - drug effects Biological and medical sciences Candida Candida - drug effects Ergosterol - biosynthesis Female Fermentation Fundamental and applied biological sciences. Psychology Mice Microbiology Pyrans - isolation & purification Pyrans - pharmacology |
| title | LANOMYCIN AND GLUCOLANOMYCIN, ANTIFUNGAL AGENTS PRODUCED BY Pycnidiophora dispersa: I. DISCOVERY, ISOLATION AND BIOLOGICAL ACTIVITY |
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