Expression of tenascin and fibronectin in the rabbit cornea after excimer laser surgery
In order to investigate the effects of excimer laser surgery on corneal wound healing, 25 rabbits underwent anterior keratectomy at a depth of 100 or 300 microns with a Meditec MEL 50 excimer laser. After various intervals the animals were killed and the cornea excised and investigated immunohistoch...
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| Veröffentlicht in: | Graefe's archive for clinical and experimental ophthalmology 1992-03, Vol.230 (2), p.178-183 |
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| container_title | Graefe's archive for clinical and experimental ophthalmology |
| container_volume | 230 |
| creator | VAN SETTEN, G.-B KOCH, J. W TERVO, K LANG, G. K TERVO, T NAUMANN, G. O. H KOLKMEIER, J VIRTANEN, I TARKKANEN, A |
| description | In order to investigate the effects of excimer laser surgery on corneal wound healing, 25 rabbits underwent anterior keratectomy at a depth of 100 or 300 microns with a Meditec MEL 50 excimer laser. After various intervals the animals were killed and the cornea excised and investigated immunohistochemically for the expression of extracellular matrix (ECM) proteins, fibronectin and tenascin. Fibronectin was shown to occur earlier than tenascin, and the two also had different distribution patterns. Wound depth showed no clear effect on the localization and time of ECM protein expression. This study indicates that corneal wounds caused by excimer laser radiation and those caused by mechanical surgery differ as to healing mechanisms. |
| doi_str_mv | 10.1007/bf00164660 |
| format | Article |
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This study indicates that corneal wounds caused by excimer laser radiation and those caused by mechanical surgery differ as to healing mechanisms.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/bf00164660</identifier><identifier>PMID: 1374356</identifier><identifier>CODEN: GACODL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Animals ; Antibodies, Monoclonal ; Biological and medical sciences ; Cell Adhesion Molecules, Neuronal - metabolism ; Cornea - metabolism ; Cornea - surgery ; Extracellular Matrix - metabolism ; Extracellular Matrix Proteins - metabolism ; Fibronectins - metabolism ; Fluorescent Antibody Technique ; Laser Therapy ; Medical sciences ; Rabbits ; Surgery (general aspects). Transplantations, organ and tissue grafts. 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Fibronectin was shown to occur earlier than tenascin, and the two also had different distribution patterns. Wound depth showed no clear effect on the localization and time of ECM protein expression. This study indicates that corneal wounds caused by excimer laser radiation and those caused by mechanical surgery differ as to healing mechanisms.</description><subject>Animals</subject><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion Molecules, Neuronal - metabolism</subject><subject>Cornea - metabolism</subject><subject>Cornea - surgery</subject><subject>Extracellular Matrix - metabolism</subject><subject>Extracellular Matrix Proteins - metabolism</subject><subject>Fibronectins - metabolism</subject><subject>Fluorescent Antibody Technique</subject><subject>Laser Therapy</subject><subject>Medical sciences</subject><subject>Rabbits</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the eye and orbit</subject><subject>Tenascin</subject><subject>Wound Healing - physiology</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUMFKAzEUDKLUWr14F3IQD8Lqy2Z3s3vU0qpQ8KLY25JkXzSyzdZkF9q_N9KqMLx5jxmGxxByzuCGAYhbZQBYkRUFHJAxy3ieCEiXh2QMImVJydPlMTkJ4RMAoshGZMS4iFsxJm-zzdpjCLZztDO0RyeDto5K11Bjle8c6j7eEf0HUi-Vsj3VnXcoqTQ9eoobbVeRWxniDIN_R789JUdGtgHP9jwhr_PZy_QxWTw_PE3vFonmQvRJLkpopCgkpJiVHBqlGKJpslyWpsxYWQBrjGRVkVXxZaG0zjVjaZMJIwAkn5CrXe7ad18Dhr5e2aCxbaXDbgi1SKs05xETcr0zat-F4NHUa29X0m9rBvVPi_X9_LfFaL7Ypw5qhc2_dVdb1C_3emxLtsZLp234s-WcV6xk_BtGunlq</recordid><startdate>19920301</startdate><enddate>19920301</enddate><creator>VAN SETTEN, G.-B</creator><creator>KOCH, J. W</creator><creator>TERVO, K</creator><creator>LANG, G. K</creator><creator>TERVO, T</creator><creator>NAUMANN, G. O. 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| identifier | ISSN: 0721-832X |
| ispartof | Graefe's archive for clinical and experimental ophthalmology, 1992-03, Vol.230 (2), p.178-183 |
| issn | 0721-832X 1435-702X |
| language | eng |
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| subjects | Animals Antibodies, Monoclonal Biological and medical sciences Cell Adhesion Molecules, Neuronal - metabolism Cornea - metabolism Cornea - surgery Extracellular Matrix - metabolism Extracellular Matrix Proteins - metabolism Fibronectins - metabolism Fluorescent Antibody Technique Laser Therapy Medical sciences Rabbits Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the eye and orbit Tenascin Wound Healing - physiology |
| title | Expression of tenascin and fibronectin in the rabbit cornea after excimer laser surgery |
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