α-1-adrenoreceptor blockade reduces the angiotensin II-induced vascular smooth muscle cell DNA synthesis in the rat thoracic aorta and carotid artery

We explored effects of alpha 1-adrenoreceptor blockade with prazosin on the increased vascular smooth muscle cell (SMC) DNA synthesis induced by angiotensin II (Ang II) in rats. Ang II was infused with or without prazosin or its solvent. Observations were compared with those in rats receiving saline...

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Veröffentlicht in:	Circulation research 1992-06, Vol.70 (6), p.1122-1127
Hauptverfasser:	VAN KLEEF, E. M, SMITS, J. F. M, DE MEY, J. G. R, CLEUTJENS, J. . M, LOMBARDI, D. M, SCHWARTZ, S. M, DAEMEN, M. J. A. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Angiotensin II - pharmacology Animals Aorta, Thoracic Biological and medical sciences Blood Pressure Blood vessels and receptors Carotid Arteries Dimethyl Sulfoxide - pharmacology DNA - biosynthesis Fundamental and applied biological sciences. Psychology Immunohistochemistry Male Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Prazosin - pharmacology Rats Rats, Inbred WKY Receptors, Adrenergic, alpha - drug effects Receptors, Adrenergic, alpha - physiology Vertebrates: cardiovascular system
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