Eleven novel single nucleotide polymorphisms in the NR1I2 (PXR) gene, four of which induce non-synonymous amino acid alterations
Eleven novel single nucleotide polymorphisms (SNPs) were found in the NR1I2 (PXR/SXR) gene from 205 Japanese subjects. The detected SNPs were as follows: 1) SNP, MPJ6_1I2001; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-TTTCTACCTCTAC/TTATTGAAAGGGC-3'. 2) SNP, MPJ6_1I2...
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| Veröffentlicht in: | Drug metabolism and pharmacokinetics 2002, Vol.17 (6), p.561-565 |
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| creator | Koyano, Satoru Kurose, Kouichi Ozawa, Shogo Saeki, Mayumi Nakajima, Yukiko Hasegawa, Ryuichi Komamura, Kazuo Ueno, Kazuyuki Kamakura, Shiro Nakajima, Toshiharu Saito, Hirohisa Kimura, Hideo Goto, Yu-ichi Saitoh, Osamu Katoh, Masaaki Ohnuma, Teiichi Kawai, Mitsuru Sugai, Kenji Ohtsuki, Taisuke Suzuki, Chieko Minami, Narihiro Saito, Yoshiro Sawada, Jun-ichi |
| description | Eleven novel single nucleotide polymorphisms (SNPs) were found in the NR1I2 (PXR/SXR) gene from 205 Japanese subjects. The detected SNPs were as follows: 1) SNP, MPJ6_1I2001; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-TTTCTACCTCTAC/TTATTGAAAGGGC-3'. 2) SNP, MPJ6_1I2004; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-AGGCCCAAATGTG/AAGTGATGCATAG-3'. 3) SNP, MPJ6_1I2007; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-TGCCAGGCCTGCC/TGCCTGCGCAAGT-3'. 4) SNP, MPJ6_1I2008; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-GAGTGAGCAGTGG/CGCGCGCGGGCGG-3'. 5) SNP, MPJ6_1I2010; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-CAGAGGAGCAGCG/AGATGATGATCAG-3'. 6) SNP, MPJ6_1I2011; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-CTGGAAGTGGCCA/GGGAGGTTCAAAG-3'. 7) SNP, MPJ6_1I2013; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-TCTTCCTCTCGCC/TCCCAACTTCTGG-3'. 8) SNP, MPJ6_1I2017; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-ATTGAATGCAATC/TGGCCCCAGCCTG-3'. 9) SNP, MPJ6_1I2018; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-GGTGAGCACAGCA/GGGGGGTGAGGAC-3'. 10) SNP, MPJ6_1I2019; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-GAGCTCCGCAGCA/GTCAATGCTCAGC-3'. 11) SNP, MPJ6_1I2021; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-GGTGACACCTCCG/AAGAGGCAGCCAG-3'. The frequencies were 0.0293 for MPJ6_1I2021, 0.0073 for MPJ6_1I2011, and 0.0024 for the other 9 SNPs. All SNPs were found as heterozygous. Among these SNPs, MPJ6_1I2007, MPJ6_1I2010, MPJ6_1I2017 and MPJ6_1I2019 induce non-synonymous amino acid alterations (R98C, R148Q, R381W and I403V, respectively, in PAR1). |
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The detected SNPs were as follows: 1) SNP, MPJ6_1I2001; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-TTTCTACCTCTAC/TTATTGAAAGGGC-3'. 2) SNP, MPJ6_1I2004; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-AGGCCCAAATGTG/AAGTGATGCATAG-3'. 3) SNP, MPJ6_1I2007; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-TGCCAGGCCTGCC/TGCCTGCGCAAGT-3'. 4) SNP, MPJ6_1I2008; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-GAGTGAGCAGTGG/CGCGCGCGGGCGG-3'. 5) SNP, MPJ6_1I2010; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-CAGAGGAGCAGCG/AGATGATGATCAG-3'. 6) SNP, MPJ6_1I2011; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-CTGGAAGTGGCCA/GGGAGGTTCAAAG-3'. 7) SNP, MPJ6_1I2013; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-TCTTCCTCTCGCC/TCCCAACTTCTGG-3'. 8) SNP, MPJ6_1I2017; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-ATTGAATGCAATC/TGGCCCCAGCCTG-3'. 9) SNP, MPJ6_1I2018; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-GGTGAGCACAGCA/GGGGGGTGAGGAC-3'. 10) SNP, MPJ6_1I2019; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-GAGCTCCGCAGCA/GTCAATGCTCAGC-3'. 11) SNP, MPJ6_1I2021; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-GGTGACACCTCCG/AAGAGGCAGCCAG-3'. The frequencies were 0.0293 for MPJ6_1I2021, 0.0073 for MPJ6_1I2011, and 0.0024 for the other 9 SNPs. All SNPs were found as heterozygous. Among these SNPs, MPJ6_1I2007, MPJ6_1I2010, MPJ6_1I2017 and MPJ6_1I2019 induce non-synonymous amino acid alterations (R98C, R148Q, R381W and I403V, respectively, in PAR1).</description><identifier>ISSN: 1347-4367</identifier><identifier>PMID: 15618712</identifier><language>eng</language><publisher>England</publisher><ispartof>Drug metabolism and pharmacokinetics, 2002, Vol.17 (6), p.561-565</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15618712$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koyano, Satoru</creatorcontrib><creatorcontrib>Kurose, Kouichi</creatorcontrib><creatorcontrib>Ozawa, Shogo</creatorcontrib><creatorcontrib>Saeki, Mayumi</creatorcontrib><creatorcontrib>Nakajima, Yukiko</creatorcontrib><creatorcontrib>Hasegawa, Ryuichi</creatorcontrib><creatorcontrib>Komamura, Kazuo</creatorcontrib><creatorcontrib>Ueno, Kazuyuki</creatorcontrib><creatorcontrib>Kamakura, Shiro</creatorcontrib><creatorcontrib>Nakajima, Toshiharu</creatorcontrib><creatorcontrib>Saito, Hirohisa</creatorcontrib><creatorcontrib>Kimura, Hideo</creatorcontrib><creatorcontrib>Goto, Yu-ichi</creatorcontrib><creatorcontrib>Saitoh, Osamu</creatorcontrib><creatorcontrib>Katoh, Masaaki</creatorcontrib><creatorcontrib>Ohnuma, Teiichi</creatorcontrib><creatorcontrib>Kawai, Mitsuru</creatorcontrib><creatorcontrib>Sugai, Kenji</creatorcontrib><creatorcontrib>Ohtsuki, Taisuke</creatorcontrib><creatorcontrib>Suzuki, Chieko</creatorcontrib><creatorcontrib>Minami, Narihiro</creatorcontrib><creatorcontrib>Saito, Yoshiro</creatorcontrib><creatorcontrib>Sawada, Jun-ichi</creatorcontrib><title>Eleven novel single nucleotide polymorphisms in the NR1I2 (PXR) gene, four of which induce non-synonymous amino acid alterations</title><title>Drug metabolism and pharmacokinetics</title><addtitle>Drug Metab Pharmacokinet</addtitle><description>Eleven novel single nucleotide polymorphisms (SNPs) were found in the NR1I2 (PXR/SXR) gene from 205 Japanese subjects. The detected SNPs were as follows: 1) SNP, MPJ6_1I2001; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-TTTCTACCTCTAC/TTATTGAAAGGGC-3'. 2) SNP, MPJ6_1I2004; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-AGGCCCAAATGTG/AAGTGATGCATAG-3'. 3) SNP, MPJ6_1I2007; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-TGCCAGGCCTGCC/TGCCTGCGCAAGT-3'. 4) SNP, MPJ6_1I2008; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-GAGTGAGCAGTGG/CGCGCGCGGGCGG-3'. 5) SNP, MPJ6_1I2010; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-CAGAGGAGCAGCG/AGATGATGATCAG-3'. 6) SNP, MPJ6_1I2011; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-CTGGAAGTGGCCA/GGGAGGTTCAAAG-3'. 7) SNP, MPJ6_1I2013; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-TCTTCCTCTCGCC/TCCCAACTTCTGG-3'. 8) SNP, MPJ6_1I2017; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-ATTGAATGCAATC/TGGCCCCAGCCTG-3'. 9) SNP, MPJ6_1I2018; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-GGTGAGCACAGCA/GGGGGGTGAGGAC-3'. 10) SNP, MPJ6_1I2019; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-GAGCTCCGCAGCA/GTCAATGCTCAGC-3'. 11) SNP, MPJ6_1I2021; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-GGTGACACCTCCG/AAGAGGCAGCCAG-3'. The frequencies were 0.0293 for MPJ6_1I2021, 0.0073 for MPJ6_1I2011, and 0.0024 for the other 9 SNPs. All SNPs were found as heterozygous. Among these SNPs, MPJ6_1I2007, MPJ6_1I2010, MPJ6_1I2017 and MPJ6_1I2019 induce non-synonymous amino acid alterations (R98C, R148Q, R381W and I403V, respectively, in PAR1).</description><issn>1347-4367</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNo1kE1Lw0AQhnNQbK3-BdmTKBjYjyTbHKVULRSV0oO3MNlMmpXNbswmldz86S5YLzO8w8PDy5xFcyYSGScik7Po0vtPSoVIE34RzViasaVkfB79rA0e0RLrjmiI1_ZgkNhRGXSDrpB0zkyt67tG-9YTbcnQIHndsQ0nd-8fu3tyQIsPpHZjT1xNvhutmoBVowoaZ2M_hRkMoyfQausIKF0RMAP2MGhn_VV0XoPxeH3ai2j_tN6vXuLt2_Nm9biNbb7kccIyAdVS0KSmkpUckpozVdUMFJRclbRCyICGlNaKCuAyl1wyyFk4lAzFIrr903a9-xrRD0WrvUJjwGIoV0ie84SmMoA3J3AsW6yKrtct9FPx_zLxC9gZaPE</recordid><startdate>2002</startdate><enddate>2002</enddate><creator>Koyano, Satoru</creator><creator>Kurose, Kouichi</creator><creator>Ozawa, Shogo</creator><creator>Saeki, Mayumi</creator><creator>Nakajima, Yukiko</creator><creator>Hasegawa, Ryuichi</creator><creator>Komamura, Kazuo</creator><creator>Ueno, Kazuyuki</creator><creator>Kamakura, Shiro</creator><creator>Nakajima, Toshiharu</creator><creator>Saito, Hirohisa</creator><creator>Kimura, Hideo</creator><creator>Goto, Yu-ichi</creator><creator>Saitoh, Osamu</creator><creator>Katoh, Masaaki</creator><creator>Ohnuma, Teiichi</creator><creator>Kawai, Mitsuru</creator><creator>Sugai, Kenji</creator><creator>Ohtsuki, Taisuke</creator><creator>Suzuki, Chieko</creator><creator>Minami, Narihiro</creator><creator>Saito, Yoshiro</creator><creator>Sawada, Jun-ichi</creator><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2002</creationdate><title>Eleven novel single nucleotide polymorphisms in the NR1I2 (PXR) gene, four of which induce non-synonymous amino acid alterations</title><author>Koyano, Satoru ; Kurose, Kouichi ; Ozawa, Shogo ; Saeki, Mayumi ; Nakajima, Yukiko ; Hasegawa, Ryuichi ; Komamura, Kazuo ; Ueno, Kazuyuki ; Kamakura, Shiro ; Nakajima, Toshiharu ; Saito, Hirohisa ; Kimura, Hideo ; Goto, Yu-ichi ; Saitoh, Osamu ; Katoh, Masaaki ; Ohnuma, Teiichi ; Kawai, Mitsuru ; Sugai, Kenji ; Ohtsuki, Taisuke ; Suzuki, Chieko ; Minami, Narihiro ; Saito, Yoshiro ; Sawada, Jun-ichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-n982-4163ad8304f071b2a4f21cdf1acab2cb0dea6a0aca5fc03a2797271a91a5fb1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koyano, Satoru</creatorcontrib><creatorcontrib>Kurose, Kouichi</creatorcontrib><creatorcontrib>Ozawa, Shogo</creatorcontrib><creatorcontrib>Saeki, Mayumi</creatorcontrib><creatorcontrib>Nakajima, Yukiko</creatorcontrib><creatorcontrib>Hasegawa, Ryuichi</creatorcontrib><creatorcontrib>Komamura, Kazuo</creatorcontrib><creatorcontrib>Ueno, Kazuyuki</creatorcontrib><creatorcontrib>Kamakura, Shiro</creatorcontrib><creatorcontrib>Nakajima, Toshiharu</creatorcontrib><creatorcontrib>Saito, Hirohisa</creatorcontrib><creatorcontrib>Kimura, Hideo</creatorcontrib><creatorcontrib>Goto, Yu-ichi</creatorcontrib><creatorcontrib>Saitoh, Osamu</creatorcontrib><creatorcontrib>Katoh, Masaaki</creatorcontrib><creatorcontrib>Ohnuma, Teiichi</creatorcontrib><creatorcontrib>Kawai, Mitsuru</creatorcontrib><creatorcontrib>Sugai, Kenji</creatorcontrib><creatorcontrib>Ohtsuki, Taisuke</creatorcontrib><creatorcontrib>Suzuki, Chieko</creatorcontrib><creatorcontrib>Minami, Narihiro</creatorcontrib><creatorcontrib>Saito, Yoshiro</creatorcontrib><creatorcontrib>Sawada, Jun-ichi</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Drug metabolism and pharmacokinetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koyano, Satoru</au><au>Kurose, Kouichi</au><au>Ozawa, Shogo</au><au>Saeki, Mayumi</au><au>Nakajima, Yukiko</au><au>Hasegawa, Ryuichi</au><au>Komamura, Kazuo</au><au>Ueno, Kazuyuki</au><au>Kamakura, Shiro</au><au>Nakajima, Toshiharu</au><au>Saito, Hirohisa</au><au>Kimura, Hideo</au><au>Goto, Yu-ichi</au><au>Saitoh, Osamu</au><au>Katoh, Masaaki</au><au>Ohnuma, Teiichi</au><au>Kawai, Mitsuru</au><au>Sugai, Kenji</au><au>Ohtsuki, Taisuke</au><au>Suzuki, Chieko</au><au>Minami, Narihiro</au><au>Saito, Yoshiro</au><au>Sawada, Jun-ichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Eleven novel single nucleotide polymorphisms in the NR1I2 (PXR) gene, four of which induce non-synonymous amino acid alterations</atitle><jtitle>Drug metabolism and pharmacokinetics</jtitle><addtitle>Drug Metab Pharmacokinet</addtitle><date>2002</date><risdate>2002</risdate><volume>17</volume><issue>6</issue><spage>561</spage><epage>565</epage><pages>561-565</pages><issn>1347-4367</issn><abstract>Eleven novel single nucleotide polymorphisms (SNPs) were found in the NR1I2 (PXR/SXR) gene from 205 Japanese subjects. The detected SNPs were as follows: 1) SNP, MPJ6_1I2001; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-TTTCTACCTCTAC/TTATTGAAAGGGC-3'. 2) SNP, MPJ6_1I2004; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-AGGCCCAAATGTG/AAGTGATGCATAG-3'. 3) SNP, MPJ6_1I2007; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-TGCCAGGCCTGCC/TGCCTGCGCAAGT-3'. 4) SNP, MPJ6_1I2008; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-GAGTGAGCAGTGG/CGCGCGCGGGCGG-3'. 5) SNP, MPJ6_1I2010; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-CAGAGGAGCAGCG/AGATGATGATCAG-3'. 6) SNP, MPJ6_1I2011; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-CTGGAAGTGGCCA/GGGAGGTTCAAAG-3'. 7) SNP, MPJ6_1I2013; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-TCTTCCTCTCGCC/TCCCAACTTCTGG-3'. 8) SNP, MPJ6_1I2017; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-ATTGAATGCAATC/TGGCCCCAGCCTG-3'. 9) SNP, MPJ6_1I2018; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-GGTGAGCACAGCA/GGGGGGTGAGGAC-3'. 10) SNP, MPJ6_1I2019; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-GAGCTCCGCAGCA/GTCAATGCTCAGC-3'. 11) SNP, MPJ6_1I2021; GENE NAME, NR1I2; ACCESSION NUMBER, AF364606; LENGTH, 25 bases; 5'-GGTGACACCTCCG/AAGAGGCAGCCAG-3'. The frequencies were 0.0293 for MPJ6_1I2021, 0.0073 for MPJ6_1I2011, and 0.0024 for the other 9 SNPs. All SNPs were found as heterozygous. Among these SNPs, MPJ6_1I2007, MPJ6_1I2010, MPJ6_1I2017 and MPJ6_1I2019 induce non-synonymous amino acid alterations (R98C, R148Q, R381W and I403V, respectively, in PAR1).</abstract><cop>England</cop><pmid>15618712</pmid><tpages>5</tpages></addata></record> |
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| title | Eleven novel single nucleotide polymorphisms in the NR1I2 (PXR) gene, four of which induce non-synonymous amino acid alterations |
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