Adenosine Release and High Energy Phosphates in Intact Dog Hearts During Norepinephrine Infusion

Cardiac adenosine release is thought to depend on the oxygen supply/demand ratio, and this effect may be mediated by changes in high energy phosphate concentrations. Previous studies supporting this hypothesis have been done primarily in isolated hearts. We tested this hypothesis in intact dog heart...

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Veröffentlicht in:	Circulation research 1992-06, Vol.70 (6), p.1146-1151
Hauptverfasser:	Gorman, Mark W, Ning, Xue-Han, He, Miao-Xiang, Portman, Michael A, Sparks, Harvey V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - metabolism Adenosine Triphosphate - metabolism Animals Biological and medical sciences Coronary Circulation Coronary Vessels Dogs Fundamental and applied biological sciences. Psychology Heart - drug effects Hemodynamics Hemodynamics. Rheology Infusions, Parenteral Magnetic Resonance Spectroscopy Models, Cardiovascular Myocardium - metabolism Norepinephrine - administration & dosage Norepinephrine - pharmacology Phosphocreatine - metabolism Time Factors Vertebrates: cardiovascular system
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