Antimalarial activity of new dihydroartemisinin derivatives. 5. Sugar analogs

A series of dihydroartemisinin derivatives containing a sugar moiety was prepared in the search for analogues with good water solubility and high antimalarial activity. The preparation of the new compounds was achieved by treatment of dihydroartemisinin (2) with chlorotrimethylsilane in pyridine sol...

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Veröffentlicht in:	Journal of medicinal chemistry 1992-05, Vol.35 (9), p.1639-1642
Hauptverfasser:	Lin, Ai J, Li, Liang Quan, Andersen, Steven L, Klayman, Daniel L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - pharmacology Artemisinins Carbohydrates - chemistry Mice Plasmodium berghei - drug effects Plasmodium falciparum - drug effects Sesquiterpenes - pharmacology
Online-Zugang:	Volltext
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