(Aminoalkoxy)chromones. Selective .sigma. receptor ligands

A series of (aminoalkoxy)chromones has been prepared, members of which bind potently (16-100 nM) at the sigma binding site and bind weakly (greater than 1000 nM) at the dopamine D2 receptor and 33 other receptors, second messenger systems, and ion channels. At the sigma receptor, the preferred posit...

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Veröffentlicht in:	Journal of medicinal chemistry 1992-05, Vol.35 (9), p.1526-1535
Hauptverfasser:	Erickson, Ronald H, Natalie, Kenneth J, Bock, William, Lu, Zhijian, Farzin, Farzaneh, Sherrill, Ronald G, Meloni, David J, Patch, Raymond J, Rzesotarski, Waclaw J
Format:	Artikel
Sprache:	eng
Schlagworte:	(aminoalkoxy)chromones Chemistry Chromones - chemical synthesis Chromones - metabolism Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Ligands opioids Organic chemistry Preparations and properties receptors Receptors, Dopamine - metabolism Receptors, Dopamine D2 Receptors, Opioid - metabolism Receptors, sigma type sigma
Online-Zugang:	Volltext
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