Changes in the linear attenuation coefficient of canine appendicular bone following intravenous infusion of strontium lactate, measured using gamma-ray computed tomography
Changes in the average linear attenuation coefficient (LAC) within a fixed measurement volume in the proximal end of the dog tibia, which contains trabecular bone and associated soft tissues (the trabecular bone "space"), were monitored continuously using gamma-ray computed tomography (gam...
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| Veröffentlicht in: | Calcified tissue international 1992-04, Vol.50 (4), p.350-356 |
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| creator | OVERTON, T. R SNYDER, R. E HANGARTNER, T. N GIRGIS, S AUDETTE, R. J SECORD, D. C |
| description | Changes in the average linear attenuation coefficient (LAC) within a fixed measurement volume in the proximal end of the dog tibia, which contains trabecular bone and associated soft tissues (the trabecular bone "space"), were monitored continuously using gamma-ray computed tomography (gamma-CT) prior to, during, and following intravenous infusion of strontium (Sr) lactate. An infusion of 1.3-4.7 g of Sr over a period of 110-160 minutes into 20-kg dogs resulted, within 6-8 hours, in an increase of 0.019-0.045 cm-1 (P less than 0.002) in the LAC. Calibration of the gamma-CT system showed that 0.44 mg/cm3 of Sr produced a change of 0.01 cm-1 in the LAC. Using this conversion factor, the Sr concentration in the trabecular bone space resulting from infusion, as measured by flame atomic absorption spectroscopy, agreed with that predicted by the change observed in the LAC. Sr present in the serum and urine was consistent with the changes observed in the LAC over the study period. Control dogs infused with mineral-free solutions showed no change in LAC. Calcium equivalents required to give the changes observed in the LAC using Sr indicate that variations in skeletal turnover in man can be monitored in the peripheral skeleton using gamma-CT. |
| doi_str_mv | 10.1007/BF00301633 |
| format | Article |
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R ; SNYDER, R. E ; HANGARTNER, T. N ; GIRGIS, S ; AUDETTE, R. J ; SECORD, D. C</creator><creatorcontrib>OVERTON, T. R ; SNYDER, R. E ; HANGARTNER, T. N ; GIRGIS, S ; AUDETTE, R. J ; SECORD, D. C</creatorcontrib><description>Changes in the average linear attenuation coefficient (LAC) within a fixed measurement volume in the proximal end of the dog tibia, which contains trabecular bone and associated soft tissues (the trabecular bone "space"), were monitored continuously using gamma-ray computed tomography (gamma-CT) prior to, during, and following intravenous infusion of strontium (Sr) lactate. An infusion of 1.3-4.7 g of Sr over a period of 110-160 minutes into 20-kg dogs resulted, within 6-8 hours, in an increase of 0.019-0.045 cm-1 (P less than 0.002) in the LAC. Calibration of the gamma-CT system showed that 0.44 mg/cm3 of Sr produced a change of 0.01 cm-1 in the LAC. Using this conversion factor, the Sr concentration in the trabecular bone space resulting from infusion, as measured by flame atomic absorption spectroscopy, agreed with that predicted by the change observed in the LAC. Sr present in the serum and urine was consistent with the changes observed in the LAC over the study period. Control dogs infused with mineral-free solutions showed no change in LAC. Calcium equivalents required to give the changes observed in the LAC using Sr indicate that variations in skeletal turnover in man can be monitored in the peripheral skeleton using gamma-CT.</description><identifier>ISSN: 0171-967X</identifier><identifier>EISSN: 1432-0827</identifier><identifier>DOI: 10.1007/BF00301633</identifier><identifier>PMID: 1571847</identifier><identifier>CODEN: CTINDZ</identifier><language>eng</language><publisher>New York, NY: Springer-Verlag</publisher><subject>Animals ; Biological and medical sciences ; Bone Density ; Bone Remodeling ; Calcification, Physiologic ; Calcium - metabolism ; Cell physiology ; Dogs ; Fundamental and applied biological sciences. Psychology ; Injections, Intravenous ; Mineralization, calcification ; Molecular and cellular biology ; Rats ; Rats, Inbred Strains ; Space life sciences ; Spectrophotometry, Atomic ; Strontium - administration & dosage ; Strontium - metabolism ; Tibia - diagnostic imaging ; Tibia - metabolism ; Tomography, X-Ray Computed</subject><ispartof>Calcified tissue international, 1992-04, Vol.50 (4), p.350-356</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c270t-f04383f54cb164a4b9ce445db58fb8755b8a10289f0d5806483840fb9b7b49823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23929,23930,25139,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5309491$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1571847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OVERTON, T. R</creatorcontrib><creatorcontrib>SNYDER, R. E</creatorcontrib><creatorcontrib>HANGARTNER, T. N</creatorcontrib><creatorcontrib>GIRGIS, S</creatorcontrib><creatorcontrib>AUDETTE, R. J</creatorcontrib><creatorcontrib>SECORD, D. C</creatorcontrib><title>Changes in the linear attenuation coefficient of canine appendicular bone following intravenous infusion of strontium lactate, measured using gamma-ray computed tomography</title><title>Calcified tissue international</title><addtitle>Calcif Tissue Int</addtitle><description>Changes in the average linear attenuation coefficient (LAC) within a fixed measurement volume in the proximal end of the dog tibia, which contains trabecular bone and associated soft tissues (the trabecular bone "space"), were monitored continuously using gamma-ray computed tomography (gamma-CT) prior to, during, and following intravenous infusion of strontium (Sr) lactate. An infusion of 1.3-4.7 g of Sr over a period of 110-160 minutes into 20-kg dogs resulted, within 6-8 hours, in an increase of 0.019-0.045 cm-1 (P less than 0.002) in the LAC. Calibration of the gamma-CT system showed that 0.44 mg/cm3 of Sr produced a change of 0.01 cm-1 in the LAC. Using this conversion factor, the Sr concentration in the trabecular bone space resulting from infusion, as measured by flame atomic absorption spectroscopy, agreed with that predicted by the change observed in the LAC. Sr present in the serum and urine was consistent with the changes observed in the LAC over the study period. Control dogs infused with mineral-free solutions showed no change in LAC. Calcium equivalents required to give the changes observed in the LAC using Sr indicate that variations in skeletal turnover in man can be monitored in the peripheral skeleton using gamma-CT.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone Density</subject><subject>Bone Remodeling</subject><subject>Calcification, Physiologic</subject><subject>Calcium - metabolism</subject><subject>Cell physiology</subject><subject>Dogs</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Intravenous</subject><subject>Mineralization, calcification</subject><subject>Molecular and cellular biology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Space life sciences</subject><subject>Spectrophotometry, Atomic</subject><subject>Strontium - administration & dosage</subject><subject>Strontium - metabolism</subject><subject>Tibia - diagnostic imaging</subject><subject>Tibia - metabolism</subject><subject>Tomography, X-Ray Computed</subject><issn>0171-967X</issn><issn>1432-0827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc2KFDEURoMoY8_oxr2QhcxCLE0qqUpqqY0zDgy4UXBX3KSS7khVUuZnpJ9pXtI03TirC_nOPZfwIfSGko-UEPHpyw0hjNCesWdoQzlrGyJb8RxtCBW0GXrx6yW6TOk3IZT3fX-BLmgnqORigx63e_A7k7DzOO8Nnp03EDHkbHyB7ILHOhhrnXbGZxws1uArg2FdjZ-cLnPFVagvNsxz-Ov8rrpyhAfjQzl6bUlHTV1NOQafXVnwDDpDNh_wYiCVaCZcobq5g2WBJsKhXl3WkmuQwxJ2Edb94RV6YWFO5vV5XqGfN19_bL81999v77af7xvdCpIbSziTzHZcK9pz4GrQhvNuUp20SoquUxIoaeVgydRJ0nPJJCdWDUooPsiWXaHrk3eN4U8xKY-LS9rMM3hTvzSKdmgpH0QF359AHUNK0dhxjW6BeBgpGY_NjE_NVPjt2VrUYqYn9FRFzd-dc0gaZhvBa5f-Yx0jAx8o-wc6Splw</recordid><startdate>19920401</startdate><enddate>19920401</enddate><creator>OVERTON, T. R</creator><creator>SNYDER, R. E</creator><creator>HANGARTNER, T. N</creator><creator>GIRGIS, S</creator><creator>AUDETTE, R. J</creator><creator>SECORD, D. C</creator><general>Springer-Verlag</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920401</creationdate><title>Changes in the linear attenuation coefficient of canine appendicular bone following intravenous infusion of strontium lactate, measured using gamma-ray computed tomography</title><author>OVERTON, T. R ; SNYDER, R. E ; HANGARTNER, T. N ; GIRGIS, S ; AUDETTE, R. J ; SECORD, D. C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c270t-f04383f54cb164a4b9ce445db58fb8755b8a10289f0d5806483840fb9b7b49823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone Density</topic><topic>Bone Remodeling</topic><topic>Calcification, Physiologic</topic><topic>Calcium - metabolism</topic><topic>Cell physiology</topic><topic>Dogs</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Intravenous</topic><topic>Mineralization, calcification</topic><topic>Molecular and cellular biology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Space life sciences</topic><topic>Spectrophotometry, Atomic</topic><topic>Strontium - administration & dosage</topic><topic>Strontium - metabolism</topic><topic>Tibia - diagnostic imaging</topic><topic>Tibia - metabolism</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OVERTON, T. R</creatorcontrib><creatorcontrib>SNYDER, R. E</creatorcontrib><creatorcontrib>HANGARTNER, T. N</creatorcontrib><creatorcontrib>GIRGIS, S</creatorcontrib><creatorcontrib>AUDETTE, R. J</creatorcontrib><creatorcontrib>SECORD, D. 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C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in the linear attenuation coefficient of canine appendicular bone following intravenous infusion of strontium lactate, measured using gamma-ray computed tomography</atitle><jtitle>Calcified tissue international</jtitle><addtitle>Calcif Tissue Int</addtitle><date>1992-04-01</date><risdate>1992</risdate><volume>50</volume><issue>4</issue><spage>350</spage><epage>356</epage><pages>350-356</pages><issn>0171-967X</issn><eissn>1432-0827</eissn><coden>CTINDZ</coden><abstract>Changes in the average linear attenuation coefficient (LAC) within a fixed measurement volume in the proximal end of the dog tibia, which contains trabecular bone and associated soft tissues (the trabecular bone "space"), were monitored continuously using gamma-ray computed tomography (gamma-CT) prior to, during, and following intravenous infusion of strontium (Sr) lactate. An infusion of 1.3-4.7 g of Sr over a period of 110-160 minutes into 20-kg dogs resulted, within 6-8 hours, in an increase of 0.019-0.045 cm-1 (P less than 0.002) in the LAC. Calibration of the gamma-CT system showed that 0.44 mg/cm3 of Sr produced a change of 0.01 cm-1 in the LAC. Using this conversion factor, the Sr concentration in the trabecular bone space resulting from infusion, as measured by flame atomic absorption spectroscopy, agreed with that predicted by the change observed in the LAC. Sr present in the serum and urine was consistent with the changes observed in the LAC over the study period. Control dogs infused with mineral-free solutions showed no change in LAC. Calcium equivalents required to give the changes observed in the LAC using Sr indicate that variations in skeletal turnover in man can be monitored in the peripheral skeleton using gamma-CT.</abstract><cop>New York, NY</cop><pub>Springer-Verlag</pub><pmid>1571847</pmid><doi>10.1007/BF00301633</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Bone Density Bone Remodeling Calcification, Physiologic Calcium - metabolism Cell physiology Dogs Fundamental and applied biological sciences. Psychology Injections, Intravenous Mineralization, calcification Molecular and cellular biology Rats Rats, Inbred Strains Space life sciences Spectrophotometry, Atomic Strontium - administration & dosage Strontium - metabolism Tibia - diagnostic imaging Tibia - metabolism Tomography, X-Ray Computed |
| title | Changes in the linear attenuation coefficient of canine appendicular bone following intravenous infusion of strontium lactate, measured using gamma-ray computed tomography |
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