Altered distribution of IgG subclasses in aspirin-induced asthma: high IgG4, low IgG1
Summary We have determined IgG subclass concentrations in 100 patients with aspirin‐induced asthma and 80 healthy controls. Patients on chronic corticotherapy (n= 64) had significantly lower total IgG levels than patients not receiving steroids (n= 36) or controls. Corticotherapy was not associated...
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| Veröffentlicht in: | Clinical and experimental allergy 1992-02, Vol.22 (2), p.283-287 |
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| container_title | Clinical and experimental allergy |
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| creator | SZCZEKLIK, A. SCHMITZ-SCHUMANN, M. NIZANKOWSKA, E. MILEWSKI, M. ROEHLIG, F. VIRCHOW, CHR |
| description | Summary
We have determined IgG subclass concentrations in 100 patients with aspirin‐induced asthma and 80 healthy controls. Patients on chronic corticotherapy (n= 64) had significantly lower total IgG levels than patients not receiving steroids (n= 36) or controls. Corticotherapy was not associated with changes in the subclass distributions. In patients, the most striking finding was elevation of IgG4. It was not related to corticotherapy or serum IgE levels. The rise in IgG4 was accompanied by a modest, though statistically significant, depression of IgG1. No changes of IgG2 and IgG3 concentrations were observed. Thus, aspirin‐induced asthma is characterized by a distinct pattern of distributions of IgG subclasses. It is suggested that in aspirin‐induced asthma elevation of IgG4 might result from chronic antigenic stimulation, of viral origin, and that determination of IgG subclass distribution might be of clinical interest. |
| doi_str_mv | 10.1111/j.1365-2222.1992.tb03084.x |
| format | Article |
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We have determined IgG subclass concentrations in 100 patients with aspirin‐induced asthma and 80 healthy controls. Patients on chronic corticotherapy (n= 64) had significantly lower total IgG levels than patients not receiving steroids (n= 36) or controls. Corticotherapy was not associated with changes in the subclass distributions. In patients, the most striking finding was elevation of IgG4. It was not related to corticotherapy or serum IgE levels. The rise in IgG4 was accompanied by a modest, though statistically significant, depression of IgG1. No changes of IgG2 and IgG3 concentrations were observed. Thus, aspirin‐induced asthma is characterized by a distinct pattern of distributions of IgG subclasses. It is suggested that in aspirin‐induced asthma elevation of IgG4 might result from chronic antigenic stimulation, of viral origin, and that determination of IgG subclass distribution might be of clinical interest.</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1111/j.1365-2222.1992.tb03084.x</identifier><identifier>PMID: 1571820</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aspirin - immunology ; Asthma - immunology ; Biological and medical sciences ; Drug toxicity and drugs side effects treatment ; Humans ; Immunoglobulin G - analysis ; Medical sciences ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Pharmacology. Drug treatments ; Tissue Distribution</subject><ispartof>Clinical and experimental allergy, 1992-02, Vol.22 (2), p.283-287</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4363-7553f0e9c9637b6a2e7bacc9c76107e80ec07f7fe1b6594048a7013ac330a37e3</citedby><cites>FETCH-LOGICAL-c4363-7553f0e9c9637b6a2e7bacc9c76107e80ec07f7fe1b6594048a7013ac330a37e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2222.1992.tb03084.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2222.1992.tb03084.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5220553$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1571820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SZCZEKLIK, A.</creatorcontrib><creatorcontrib>SCHMITZ-SCHUMANN, M.</creatorcontrib><creatorcontrib>NIZANKOWSKA, E.</creatorcontrib><creatorcontrib>MILEWSKI, M.</creatorcontrib><creatorcontrib>ROEHLIG, F.</creatorcontrib><creatorcontrib>VIRCHOW, CHR</creatorcontrib><title>Altered distribution of IgG subclasses in aspirin-induced asthma: high IgG4, low IgG1</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description>Summary
We have determined IgG subclass concentrations in 100 patients with aspirin‐induced asthma and 80 healthy controls. Patients on chronic corticotherapy (n= 64) had significantly lower total IgG levels than patients not receiving steroids (n= 36) or controls. Corticotherapy was not associated with changes in the subclass distributions. In patients, the most striking finding was elevation of IgG4. It was not related to corticotherapy or serum IgE levels. The rise in IgG4 was accompanied by a modest, though statistically significant, depression of IgG1. No changes of IgG2 and IgG3 concentrations were observed. Thus, aspirin‐induced asthma is characterized by a distinct pattern of distributions of IgG subclasses. It is suggested that in aspirin‐induced asthma elevation of IgG4 might result from chronic antigenic stimulation, of viral origin, and that determination of IgG subclass distribution might be of clinical interest.</description><subject>Aspirin - immunology</subject><subject>Asthma - immunology</subject><subject>Biological and medical sciences</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Humans</subject><subject>Immunoglobulin G - analysis</subject><subject>Medical sciences</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Pharmacology. Drug treatments</subject><subject>Tissue Distribution</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkV2L1DAUhoMo67j6E4Qi4pWtJ0mTNHshDOM6LizKgouXIc2c7mTstGPSsrP_3pQO47XnJoH3I8kTQt5RKGiaT7uCcilylqagWrNiqIFDVRbHZ2Rxlp6TBWhR5qrS5UvyKsYdAHChqwtyQYWiFYMFuV-2AwbcZBsfh-DrcfB9l_VNdvOwzuJYu9bGiDHzXWbjwQff5b7bjC4lbBy2e3uVbf3DdrKXH7O2f5x29DV50dg24pvTeknuv17_XH3Lb3-sb1bL29yVXPJcCcEbQO205KqWlqGqrXPaKUlBYQXoQDWqQVpLoUsoK6uAcus4B8sV8kvyYe49hP7PiHEwex8dtq3tsB-jUUwzyrRKxqvZ6EIfY8DGHILf2_BkKJiJqdmZCZyZwJmJqTkxNccUfns6Zaz3uPkXnSEm_f1Jt9HZtgm2cz6ebYIxSA9Nts-z7dG3-PQfFzCr6yWrpoJ8LkhfhcdzgQ2_jVRcCfPr-9qA1F_kXXlnFP8LNXGgeg</recordid><startdate>199202</startdate><enddate>199202</enddate><creator>SZCZEKLIK, A.</creator><creator>SCHMITZ-SCHUMANN, M.</creator><creator>NIZANKOWSKA, E.</creator><creator>MILEWSKI, M.</creator><creator>ROEHLIG, F.</creator><creator>VIRCHOW, CHR</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199202</creationdate><title>Altered distribution of IgG subclasses in aspirin-induced asthma: high IgG4, low IgG1</title><author>SZCZEKLIK, A. ; SCHMITZ-SCHUMANN, M. ; NIZANKOWSKA, E. ; MILEWSKI, M. ; ROEHLIG, F. ; VIRCHOW, CHR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4363-7553f0e9c9637b6a2e7bacc9c76107e80ec07f7fe1b6594048a7013ac330a37e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Aspirin - immunology</topic><topic>Asthma - immunology</topic><topic>Biological and medical sciences</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Humans</topic><topic>Immunoglobulin G - analysis</topic><topic>Medical sciences</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Pharmacology. Drug treatments</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SZCZEKLIK, A.</creatorcontrib><creatorcontrib>SCHMITZ-SCHUMANN, M.</creatorcontrib><creatorcontrib>NIZANKOWSKA, E.</creatorcontrib><creatorcontrib>MILEWSKI, M.</creatorcontrib><creatorcontrib>ROEHLIG, F.</creatorcontrib><creatorcontrib>VIRCHOW, CHR</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SZCZEKLIK, A.</au><au>SCHMITZ-SCHUMANN, M.</au><au>NIZANKOWSKA, E.</au><au>MILEWSKI, M.</au><au>ROEHLIG, F.</au><au>VIRCHOW, CHR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered distribution of IgG subclasses in aspirin-induced asthma: high IgG4, low IgG1</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>1992-02</date><risdate>1992</risdate><volume>22</volume><issue>2</issue><spage>283</spage><epage>287</epage><pages>283-287</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Summary
We have determined IgG subclass concentrations in 100 patients with aspirin‐induced asthma and 80 healthy controls. Patients on chronic corticotherapy (n= 64) had significantly lower total IgG levels than patients not receiving steroids (n= 36) or controls. Corticotherapy was not associated with changes in the subclass distributions. In patients, the most striking finding was elevation of IgG4. It was not related to corticotherapy or serum IgE levels. The rise in IgG4 was accompanied by a modest, though statistically significant, depression of IgG1. No changes of IgG2 and IgG3 concentrations were observed. Thus, aspirin‐induced asthma is characterized by a distinct pattern of distributions of IgG subclasses. It is suggested that in aspirin‐induced asthma elevation of IgG4 might result from chronic antigenic stimulation, of viral origin, and that determination of IgG subclass distribution might be of clinical interest.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>1571820</pmid><doi>10.1111/j.1365-2222.1992.tb03084.x</doi><tpages>5</tpages></addata></record> |
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| ispartof | Clinical and experimental allergy, 1992-02, Vol.22 (2), p.283-287 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aspirin - immunology Asthma - immunology Biological and medical sciences Drug toxicity and drugs side effects treatment Humans Immunoglobulin G - analysis Medical sciences Miscellaneous (drug allergy, mutagens, teratogens...) Pharmacology. Drug treatments Tissue Distribution |
| title | Altered distribution of IgG subclasses in aspirin-induced asthma: high IgG4, low IgG1 |
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