Metabolic improvements and use of inexpensive carbon sources in microbial production of polyhydroxyalkanoates
This paper deals with the microbial production of polyhydroxyalkanoates (PHAs), biodegradable thermoplastics which perform excellently as a material, from inexpensive renewable carbon sources. To date, with the help of genetic engineering techniques, it has become possible to design several types of...
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| Veröffentlicht in: | Journal of Bioscience and Bioengineering 2002-12, Vol.94 (6), p.579-584 |
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| container_title | Journal of Bioscience and Bioengineering |
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| creator | Tsuge, Takeharu |
| description | This paper deals with the microbial production of polyhydroxyalkanoates (PHAs), biodegradable thermoplastics which perform excellently as a material, from inexpensive renewable carbon sources. To date, with the help of genetic engineering techniques, it has become possible to design several types of PHAs with different compositions and to enhance the productivities of PHAs. In addition, molecular breeding of PHA biosynthesis enzymes has been demonstrated to improve polymer production. Mutant PHA synthases generated by an
in vitro evolution technique have allowed the enhanced production and quality alteration of PHAs. Furthermore, use of inexpensive renewable carbon sources, such as plant oils, waste materials, and carbon dioxide, would be a key for a reduction in PHA production cost. |
| doi_str_mv | 10.1016/S1389-1723(02)80198-0 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1389-1723 |
| ispartof | Journal of Bioscience and Bioengineering, 2002-12, Vol.94 (6), p.579-584 |
| issn | 1389-1723 1347-4421 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72921108 |
| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Bacteriology BIOCHEMICAL PATHWAYS Biological and medical sciences BIOPOLYMERS BIOTECHNOLOGY CARBON engineered metabolic pathway Fundamental and applied biological sciences. Psychology inexpensive carbon source material property Metabolism. Enzymes Microbiology molecular breeding polyhydroxyalkanoates |
| title | Metabolic improvements and use of inexpensive carbon sources in microbial production of polyhydroxyalkanoates |
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