Clinical subtypes and age at onset in schizophrenic siblings
This study examines the concordance of clinical subtypes and age at onset of schizophrenia in 42 sibships of multiply affected schizophrenic patients. Subtypes were defined by four major diagnostic systems ( DSM-III, DSM-III-R, ICD-10, and Tsuang-Winokur criteria) and rated both for the first hospit...
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| Veröffentlicht in: | Psychiatry research 1992-02, Vol.41 (2), p.107-114 |
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| container_title | Psychiatry research |
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| creator | Leboyer, Marion Filteau, Marie-Josée Jay, Maurice Campion, Dominique d'Amato, Thierry Guilloud-Bataille, Michel Hillaire, Dominique Feingold, Josué des Lauriers, André Widlöcher, Daniel |
| description | This study examines the concordance of clinical subtypes and age at onset of schizophrenia in 42 sibships of multiply affected schizophrenic patients. Subtypes were defined by four major diagnostic systems (
DSM-III, DSM-III-R, ICD-10, and Tsuang-Winokur criteria) and rated both for the first hospitalization and long-term diagnosis. When a sibship method was used, no concordance for subtypes was found in siblings. Age at onset, analyzed as a continuous variable with the intraclass correlation method, was found to be correlated in siblings. This finding suggests that the search for continous traits distributed in families of schizophrenic patients might constitute an alternative to discrete category- based family studies. |
| doi_str_mv | 10.1016/0165-1781(92)90103-A |
| format | Article |
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DSM-III, DSM-III-R, ICD-10, and Tsuang-Winokur criteria) and rated both for the first hospitalization and long-term diagnosis. When a sibship method was used, no concordance for subtypes was found in siblings. Age at onset, analyzed as a continuous variable with the intraclass correlation method, was found to be correlated in siblings. This finding suggests that the search for continous traits distributed in families of schizophrenic patients might constitute an alternative to discrete category- based family studies.</description><subject>Adult and adolescent clinical studies</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>clinical subtypes</subject><subject>diagnosis</subject><subject>Family studies</subject><subject>genetics</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Risk Factors</subject><subject>Schizophrenia - classification</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - genetics</subject><subject>Schizophrenia, Disorganized - classification</subject><subject>Schizophrenia, Disorganized - diagnosis</subject><subject>Schizophrenia, Disorganized - genetics</subject><subject>Schizophrenia, Paranoid - classification</subject><subject>Schizophrenia, Paranoid - diagnosis</subject><subject>Schizophrenia, Paranoid - genetics</subject><subject>Schizophrenic Psychology</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotX78A4U9iOhhNZPsNhsQoRS_QPCi55DNzraR7W7NbAX99aa21JuHYQ7zvDPDw9gJ8CvgMLqOlaegCrjQ4lJz4DId77AhFEqkCoTcZcMtss8OiN455wK0HrAB5CrLZTFkN5PGt97ZJqFl2X8tkBLbVomdYmL7pGsJ-8S3CbmZ_-4Ws4ARTsiXMTWlI7ZX24bweNMP2dv93evkMX1-eXiajJ9TJ4tRn-p4SlQoqzKThch1afMKJDiVaSXAckQnapFDVRa2lhZGwkmlR2UprHXKFvKQna_3LkL3sUTqzdyTw6axLXZLMkpoweOpCGZr0IWOKGBtFsHPbfgywM1KmlkZMSsjRgvzK82MY-x0s39ZzrH6C60txfnZZm4pqqqDbZ2nLZaDzDKZR-x2jWF08ekxGHIeW4eVD-h6U3X-_z9-AFMuh14</recordid><startdate>19920201</startdate><enddate>19920201</enddate><creator>Leboyer, Marion</creator><creator>Filteau, Marie-Josée</creator><creator>Jay, Maurice</creator><creator>Campion, Dominique</creator><creator>d'Amato, Thierry</creator><creator>Guilloud-Bataille, Michel</creator><creator>Hillaire, Dominique</creator><creator>Feingold, Josué</creator><creator>des Lauriers, André</creator><creator>Widlöcher, Daniel</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920201</creationdate><title>Clinical subtypes and age at onset in schizophrenic siblings</title><author>Leboyer, Marion ; Filteau, Marie-Josée ; Jay, Maurice ; Campion, Dominique ; d'Amato, Thierry ; Guilloud-Bataille, Michel ; Hillaire, Dominique ; Feingold, Josué ; des Lauriers, André ; Widlöcher, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-94532de3db438259ba5d131c749721a0eec2f251db8af3a162c3796bb2aac7a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>clinical subtypes</topic><topic>diagnosis</topic><topic>Family studies</topic><topic>genetics</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Risk Factors</topic><topic>Schizophrenia - classification</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - genetics</topic><topic>Schizophrenia, Disorganized - classification</topic><topic>Schizophrenia, Disorganized - diagnosis</topic><topic>Schizophrenia, Disorganized - genetics</topic><topic>Schizophrenia, Paranoid - classification</topic><topic>Schizophrenia, Paranoid - diagnosis</topic><topic>Schizophrenia, Paranoid - genetics</topic><topic>Schizophrenic Psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leboyer, Marion</creatorcontrib><creatorcontrib>Filteau, Marie-Josée</creatorcontrib><creatorcontrib>Jay, Maurice</creatorcontrib><creatorcontrib>Campion, Dominique</creatorcontrib><creatorcontrib>d'Amato, Thierry</creatorcontrib><creatorcontrib>Guilloud-Bataille, Michel</creatorcontrib><creatorcontrib>Hillaire, Dominique</creatorcontrib><creatorcontrib>Feingold, Josué</creatorcontrib><creatorcontrib>des Lauriers, André</creatorcontrib><creatorcontrib>Widlöcher, Daniel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leboyer, Marion</au><au>Filteau, Marie-Josée</au><au>Jay, Maurice</au><au>Campion, Dominique</au><au>d'Amato, Thierry</au><au>Guilloud-Bataille, Michel</au><au>Hillaire, Dominique</au><au>Feingold, Josué</au><au>des Lauriers, André</au><au>Widlöcher, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical subtypes and age at onset in schizophrenic siblings</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>1992-02-01</date><risdate>1992</risdate><volume>41</volume><issue>2</issue><spage>107</spage><epage>114</epage><pages>107-114</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>This study examines the concordance of clinical subtypes and age at onset of schizophrenia in 42 sibships of multiply affected schizophrenic patients. Subtypes were defined by four major diagnostic systems (
DSM-III, DSM-III-R, ICD-10, and Tsuang-Winokur criteria) and rated both for the first hospitalization and long-term diagnosis. When a sibship method was used, no concordance for subtypes was found in siblings. Age at onset, analyzed as a continuous variable with the intraclass correlation method, was found to be correlated in siblings. This finding suggests that the search for continous traits distributed in families of schizophrenic patients might constitute an alternative to discrete category- based family studies.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>1574538</pmid><doi>10.1016/0165-1781(92)90103-A</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies Age Factors Biological and medical sciences clinical subtypes diagnosis Family studies genetics Hospitalization Humans Medical sciences Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Risk Factors Schizophrenia - classification Schizophrenia - diagnosis Schizophrenia - genetics Schizophrenia, Disorganized - classification Schizophrenia, Disorganized - diagnosis Schizophrenia, Disorganized - genetics Schizophrenia, Paranoid - classification Schizophrenia, Paranoid - diagnosis Schizophrenia, Paranoid - genetics Schizophrenic Psychology |
| title | Clinical subtypes and age at onset in schizophrenic siblings |
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