Synthesis and in vitro evaluation of boronated uridine and glucose derivatives for boron neutron capture therapy

The following boron-containing nucleoside and glucose derivatives have been synthesized as potential boron delivery agents for boron neutron capture therapy (BNCT): 2'-O-(o-carboran-1-ylmethyl)uridine (4a), 3'-O-(o-carboran-1-ylmethyl)uridine (4b), sodium 7-(uridin-2'-ylmethyl)dodecah...

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Veröffentlicht in:	Journal of medicinal chemistry 1992-05, Vol.35 (9), p.1628-1633
Hauptverfasser:	Tjarks, Werner, Anisuzzaman, Abul K. M, Liu, Liang, Soloway, Albert H, Barth, Rolf F, Perkins, Douglas J, Adams, Dianne M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B derivatives Boron Chemistry Exact sciences and technology Glioma - metabolism Glioma - radiotherapy Glucose - analogs & derivatives Glucose - chemical synthesis Glucose - pharmacology Neutrons Organic chemistry Organometalloidal and organometallic compounds Preparations and properties Radiotherapy, High-Energy Rats Tumor Cells, Cultured Uridine - analogs & derivatives Uridine - chemical synthesis Uridine - pharmacology
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