The NK‐1 Receptor and a Calcium‐Phospholipid Pathway: Inositol Trisphosphate Production and Calcium Movements Induced by Selective Agonists of Neurokinin Receptors in Rat Parotid Glands

: In the rat parotid gland, substance P has been shown to induce a phosphatidylinositol bisphosphate breakdown resulting in an inositol trisphosphate production. These data suggested that substance P activated a phospholipase C and thus mediated its effects through the calcium‐phospholipid pathway....

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Veröffentlicht in:	Journal of neurochemistry 1992-06, Vol.58 (6), p.2321-2325
Hauptverfasser:	Guillemain, Isabelle, Rollandy, Isabelle, Imhoff, Viviane, Rossignol, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium Calcium - metabolism Calcium - physiology Fundamental and applied biological sciences. Psychology Inositol 1,4,5-Trisphosphate - metabolism Inositol trisphosphate Male Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus NK‐1 receptor Parotid Gland - metabolism Parotid Gland - physiology Parotid Gland - ultrastructure Peptide Fragments - pharmacology Phospholipids - physiology Rats Rats, Inbred Strains Receptors, Neurokinin-2 Receptors, Neurotransmitter - drug effects Receptors, Neurotransmitter - physiology Signal Transduction - physiology Substance P Substance P - analogs & derivatives Substance P - pharmacology Vertebrates: digestive system
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