White matter hyperintensity signals in psychiatric and nonpsychiatric subjects
OBJECTIVE: As part of an ongoing study investigating the relationship between brain morphology/function and neuropsychological performance in psychopathology, the authors conducted brain magnetic resonance imaging (MRI) studies to investigate the prevalence and psychiatric significance of white matt...
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| Veröffentlicht in: | The American journal of psychiatry 1992-05, Vol.149 (5), p.620-625 |
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| container_title | The American journal of psychiatry |
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| creator | BROWN, F. W LEWINE, R. J HUDGINS, P. A RISCH, S. C |
| description | OBJECTIVE: As part of an ongoing study investigating the relationship
between brain morphology/function and neuropsychological performance in
psychopathology, the authors conducted brain magnetic resonance imaging
(MRI) studies to investigate the prevalence and psychiatric significance of
white matter hyperintensity signals. METHOD: Brain MRI acquisition was done
with 0.5 and 1.5 Tesla Philips scanners. Psychiatric subjects (N = 229) and
normal volunteers (N = 154) were recruited by newspaper and local
advertising and by physician referral. DSM-III-R criteria were used. White
matter hyperintensity signals were rated on a 4-point scale of severity.
Prevalence rates and risk ratios were calculated. RESULTS: Prevalence rates
of hyperintensity signals in all psychiatric subjects (mean age = 34 years,
SD = 9) and normal volunteers (mean age = 34, SD = 10) were 6.6% and 9.1%,
respectively (a nonsignificant difference). When all psychiatric subjects,
subjects under age 45, and subjects age 45 and over in a diagnostic
category were considered, there were no statistically significant
differences between them and normal volunteers in the same age groups in
prevalence of schizophrenia, schizoaffective disorder, bipolar disorder,
major depression, and obsessive-compulsive disorder. A significant
difference existed between the severity of deep white matter hyperintensity
signals in subjects with major depression and normal volunteers. Older age
was correlated as a risk factor for white matter hyperintensity signals for
psychiatric subjects. CONCLUSIONS: These results do not support previous
findings of greater prevalence of hyperintensity signals in bipolar
disorder. Significantly higher prevalence rates of hyperintensity signals
were seen in subjects with major depression only when severity of the deep
white matter hyperintensity signals was considered. Older age is an
indirect risk factor for the presence of white matter hypertensity signals,
probably as a result of vascular changes associated with concurrent medical
illnesses. |
| doi_str_mv | 10.1176/ajp.149.5.620 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72914199</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1310607164</sourcerecordid><originalsourceid>FETCH-LOGICAL-a407t-94f7f77e1048cd6ec50d353913713f67254a0457013898f4666804a52157b2f73</originalsourceid><addsrcrecordid>eNp10ctKAzEUBuAgitbL0qUwqLgQpubkOrOU4g1EN4ruQppmbEqbGZPMom9vpEVFdBWS8yU5yY_QIeAhgBQXetYNgdVDPhQEb6ABcMpLSUi1iQYYY1LWnL7uoN0YZ3mKqSTbaBu45ITDAD28TF2yxUKnZEMxXXY2OJ-sjy4ti-jevJ7Hwvmii0szdToFZwrtJ4Vv_c-l2I9n1qS4j7aavMMerMc99Hx99TS6Le8fb-5Gl_elZlimsmaNbKS0gFllJsIajieU0xqoBNoISTjTmHGJgVZ11TAhRIWZ5iT3PSaNpHvobHVuF9r33sakFi4aO59rb9s-KklqYFDXGR7_grO2D5-vUoRgJnMHNKOT_xBQwAJLECyrcqVMaGMMtlFdcAsdlgqw-oxC5ShUjkJxlaPI_mh9aj9e2Mm3Xv19rp-u6zoaPW-C9sbFL5YNr1iV2fmK6a5zPxr7884PE_mcjw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1310607164</pqid></control><display><type>article</type><title>White matter hyperintensity signals in psychiatric and nonpsychiatric subjects</title><source>MEDLINE</source><source>Psychiatry Legacy Collection Online Journals 1844-1996</source><source>Periodicals Index Online</source><creator>BROWN, F. W ; LEWINE, R. J ; HUDGINS, P. A ; RISCH, S. C</creator><creatorcontrib>BROWN, F. W ; LEWINE, R. J ; HUDGINS, P. A ; RISCH, S. C</creatorcontrib><description>OBJECTIVE: As part of an ongoing study investigating the relationship
between brain morphology/function and neuropsychological performance in
psychopathology, the authors conducted brain magnetic resonance imaging
(MRI) studies to investigate the prevalence and psychiatric significance of
white matter hyperintensity signals. METHOD: Brain MRI acquisition was done
with 0.5 and 1.5 Tesla Philips scanners. Psychiatric subjects (N = 229) and
normal volunteers (N = 154) were recruited by newspaper and local
advertising and by physician referral. DSM-III-R criteria were used. White
matter hyperintensity signals were rated on a 4-point scale of severity.
Prevalence rates and risk ratios were calculated. RESULTS: Prevalence rates
of hyperintensity signals in all psychiatric subjects (mean age = 34 years,
SD = 9) and normal volunteers (mean age = 34, SD = 10) were 6.6% and 9.1%,
respectively (a nonsignificant difference). When all psychiatric subjects,
subjects under age 45, and subjects age 45 and over in a diagnostic
category were considered, there were no statistically significant
differences between them and normal volunteers in the same age groups in
prevalence of schizophrenia, schizoaffective disorder, bipolar disorder,
major depression, and obsessive-compulsive disorder. A significant
difference existed between the severity of deep white matter hyperintensity
signals in subjects with major depression and normal volunteers. Older age
was correlated as a risk factor for white matter hyperintensity signals for
psychiatric subjects. CONCLUSIONS: These results do not support previous
findings of greater prevalence of hyperintensity signals in bipolar
disorder. Significantly higher prevalence rates of hyperintensity signals
were seen in subjects with major depression only when severity of the deep
white matter hyperintensity signals was considered. Older age is an
indirect risk factor for the presence of white matter hypertensity signals,
probably as a result of vascular changes associated with concurrent medical
illnesses.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/ajp.149.5.620</identifier><identifier>PMID: 1575251</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Adult ; Age Factors ; Biological and medical sciences ; Brain ; Brain - anatomy & histology ; Brain - pathology ; Brain Diseases - complications ; Brain Diseases - epidemiology ; Brain Diseases - pathology ; Depressive Disorder - complications ; Depressive Disorder - diagnosis ; Depressive Disorder - pathology ; Female ; Humans ; Magnetic Resonance Imaging - statistics & numerical data ; Male ; Medical research ; Medical sciences ; Mental depression ; Mental disorders ; Mental Disorders - complications ; Mental Disorders - diagnosis ; Mental Disorders - pathology ; Methodology. Experimentation ; Middle Aged ; Prevalence ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Risk Factors ; Techniques and methods</subject><ispartof>The American journal of psychiatry, 1992-05, Vol.149 (5), p.620-625</ispartof><rights>1992 INIST-CNRS</rights><rights>Copyright American Psychiatric Association May 1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a407t-94f7f77e1048cd6ec50d353913713f67254a0457013898f4666804a52157b2f73</citedby><cites>FETCH-LOGICAL-a407t-94f7f77e1048cd6ec50d353913713f67254a0457013898f4666804a52157b2f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/ajp.149.5.620$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/ajp.149.5.620$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,780,784,2859,21629,27869,27924,27925,77791,77792</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5255848$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1575251$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BROWN, F. W</creatorcontrib><creatorcontrib>LEWINE, R. J</creatorcontrib><creatorcontrib>HUDGINS, P. A</creatorcontrib><creatorcontrib>RISCH, S. C</creatorcontrib><title>White matter hyperintensity signals in psychiatric and nonpsychiatric subjects</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: As part of an ongoing study investigating the relationship
between brain morphology/function and neuropsychological performance in
psychopathology, the authors conducted brain magnetic resonance imaging
(MRI) studies to investigate the prevalence and psychiatric significance of
white matter hyperintensity signals. METHOD: Brain MRI acquisition was done
with 0.5 and 1.5 Tesla Philips scanners. Psychiatric subjects (N = 229) and
normal volunteers (N = 154) were recruited by newspaper and local
advertising and by physician referral. DSM-III-R criteria were used. White
matter hyperintensity signals were rated on a 4-point scale of severity.
Prevalence rates and risk ratios were calculated. RESULTS: Prevalence rates
of hyperintensity signals in all psychiatric subjects (mean age = 34 years,
SD = 9) and normal volunteers (mean age = 34, SD = 10) were 6.6% and 9.1%,
respectively (a nonsignificant difference). When all psychiatric subjects,
subjects under age 45, and subjects age 45 and over in a diagnostic
category were considered, there were no statistically significant
differences between them and normal volunteers in the same age groups in
prevalence of schizophrenia, schizoaffective disorder, bipolar disorder,
major depression, and obsessive-compulsive disorder. A significant
difference existed between the severity of deep white matter hyperintensity
signals in subjects with major depression and normal volunteers. Older age
was correlated as a risk factor for white matter hyperintensity signals for
psychiatric subjects. CONCLUSIONS: These results do not support previous
findings of greater prevalence of hyperintensity signals in bipolar
disorder. Significantly higher prevalence rates of hyperintensity signals
were seen in subjects with major depression only when severity of the deep
white matter hyperintensity signals was considered. Older age is an
indirect risk factor for the presence of white matter hypertensity signals,
probably as a result of vascular changes associated with concurrent medical
illnesses.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - anatomy & histology</subject><subject>Brain - pathology</subject><subject>Brain Diseases - complications</subject><subject>Brain Diseases - epidemiology</subject><subject>Brain Diseases - pathology</subject><subject>Depressive Disorder - complications</subject><subject>Depressive Disorder - diagnosis</subject><subject>Depressive Disorder - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - statistics & numerical data</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mental Disorders - complications</subject><subject>Mental Disorders - diagnosis</subject><subject>Mental Disorders - pathology</subject><subject>Methodology. Experimentation</subject><subject>Middle Aged</subject><subject>Prevalence</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Risk Factors</subject><subject>Techniques and methods</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNp10ctKAzEUBuAgitbL0qUwqLgQpubkOrOU4g1EN4ruQppmbEqbGZPMom9vpEVFdBWS8yU5yY_QIeAhgBQXetYNgdVDPhQEb6ABcMpLSUi1iQYYY1LWnL7uoN0YZ3mKqSTbaBu45ITDAD28TF2yxUKnZEMxXXY2OJ-sjy4ti-jevJ7Hwvmii0szdToFZwrtJ4Vv_c-l2I9n1qS4j7aavMMerMc99Hx99TS6Le8fb-5Gl_elZlimsmaNbKS0gFllJsIajieU0xqoBNoISTjTmHGJgVZ11TAhRIWZ5iT3PSaNpHvobHVuF9r33sakFi4aO59rb9s-KklqYFDXGR7_grO2D5-vUoRgJnMHNKOT_xBQwAJLECyrcqVMaGMMtlFdcAsdlgqw-oxC5ShUjkJxlaPI_mh9aj9e2Mm3Xv19rp-u6zoaPW-C9sbFL5YNr1iV2fmK6a5zPxr7884PE_mcjw</recordid><startdate>19920501</startdate><enddate>19920501</enddate><creator>BROWN, F. W</creator><creator>LEWINE, R. J</creator><creator>HUDGINS, P. A</creator><creator>RISCH, S. 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W ; LEWINE, R. J ; HUDGINS, P. A ; RISCH, S. 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Experimentation</topic><topic>Middle Aged</topic><topic>Prevalence</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Risk Factors</topic><topic>Techniques and methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BROWN, F. W</creatorcontrib><creatorcontrib>LEWINE, R. J</creatorcontrib><creatorcontrib>HUDGINS, P. A</creatorcontrib><creatorcontrib>RISCH, S. 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W</au><au>LEWINE, R. J</au><au>HUDGINS, P. A</au><au>RISCH, S. C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>White matter hyperintensity signals in psychiatric and nonpsychiatric subjects</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>1992-05-01</date><risdate>1992</risdate><volume>149</volume><issue>5</issue><spage>620</spage><epage>625</epage><pages>620-625</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: As part of an ongoing study investigating the relationship
between brain morphology/function and neuropsychological performance in
psychopathology, the authors conducted brain magnetic resonance imaging
(MRI) studies to investigate the prevalence and psychiatric significance of
white matter hyperintensity signals. METHOD: Brain MRI acquisition was done
with 0.5 and 1.5 Tesla Philips scanners. Psychiatric subjects (N = 229) and
normal volunteers (N = 154) were recruited by newspaper and local
advertising and by physician referral. DSM-III-R criteria were used. White
matter hyperintensity signals were rated on a 4-point scale of severity.
Prevalence rates and risk ratios were calculated. RESULTS: Prevalence rates
of hyperintensity signals in all psychiatric subjects (mean age = 34 years,
SD = 9) and normal volunteers (mean age = 34, SD = 10) were 6.6% and 9.1%,
respectively (a nonsignificant difference). When all psychiatric subjects,
subjects under age 45, and subjects age 45 and over in a diagnostic
category were considered, there were no statistically significant
differences between them and normal volunteers in the same age groups in
prevalence of schizophrenia, schizoaffective disorder, bipolar disorder,
major depression, and obsessive-compulsive disorder. A significant
difference existed between the severity of deep white matter hyperintensity
signals in subjects with major depression and normal volunteers. Older age
was correlated as a risk factor for white matter hyperintensity signals for
psychiatric subjects. CONCLUSIONS: These results do not support previous
findings of greater prevalence of hyperintensity signals in bipolar
disorder. Significantly higher prevalence rates of hyperintensity signals
were seen in subjects with major depression only when severity of the deep
white matter hyperintensity signals was considered. Older age is an
indirect risk factor for the presence of white matter hypertensity signals,
probably as a result of vascular changes associated with concurrent medical
illnesses.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>1575251</pmid><doi>10.1176/ajp.149.5.620</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-953X |
| ispartof | The American journal of psychiatry, 1992-05, Vol.149 (5), p.620-625 |
| issn | 0002-953X 1535-7228 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72914199 |
| source | MEDLINE; Psychiatry Legacy Collection Online Journals 1844-1996; Periodicals Index Online |
| subjects | Adult Age Factors Biological and medical sciences Brain Brain - anatomy & histology Brain - pathology Brain Diseases - complications Brain Diseases - epidemiology Brain Diseases - pathology Depressive Disorder - complications Depressive Disorder - diagnosis Depressive Disorder - pathology Female Humans Magnetic Resonance Imaging - statistics & numerical data Male Medical research Medical sciences Mental depression Mental disorders Mental Disorders - complications Mental Disorders - diagnosis Mental Disorders - pathology Methodology. Experimentation Middle Aged Prevalence Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk Factors Techniques and methods |
| title | White matter hyperintensity signals in psychiatric and nonpsychiatric subjects |
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