Involvement of antibacterial peptide defensin in tick midgut defense
Animals are constantly threatened by pathogenic microorganisms and have developed cellular and humoral immune responses to combat these infections. Invertebrates possess only an innate non-specific immune response. Antimicrobial substances are major components of innate immunity not only in inverteb...
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| Veröffentlicht in: | Experimental & applied acarology 2002-01, Vol.28 (1-4), p.135-140 |
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| container_title | Experimental & applied acarology |
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| creator | Nakajima, Y Taylor, D Yamakawa, M |
| description | Animals are constantly threatened by pathogenic microorganisms and have developed cellular and humoral immune responses to combat these infections. Invertebrates possess only an innate non-specific immune response. Antimicrobial substances are major components of innate immunity not only in invertebrates but also in vertebrates. Despite the importance of ticks as vectors of disease very little is known about their immune system. Our recent studies have revealed that four defensin isoforms are present in Ornithodoros moubata. These four isoforms are constitutively expressed in the midgut and up-regulated in response to blood feeding. Moreover, a mature peptide of defensin isoform A has been isolated from the tick midgut lumen. These findings indicate Ornithodoros defensins are involved in tick midgut defense against potentially harmful invasive microbes. |
| doi_str_mv | 10.1023/a:1025399610947 |
| format | Article |
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Invertebrates possess only an innate non-specific immune response. Antimicrobial substances are major components of innate immunity not only in invertebrates but also in vertebrates. Despite the importance of ticks as vectors of disease very little is known about their immune system. Our recent studies have revealed that four defensin isoforms are present in Ornithodoros moubata. These four isoforms are constitutively expressed in the midgut and up-regulated in response to blood feeding. Moreover, a mature peptide of defensin isoform A has been isolated from the tick midgut lumen. These findings indicate Ornithodoros defensins are involved in tick midgut defense against potentially harmful invasive microbes.</description><identifier>ISSN: 0168-8162</identifier><identifier>EISSN: 1572-9702</identifier><identifier>DOI: 10.1023/a:1025399610947</identifier><identifier>PMID: 14570123</identifier><identifier>CODEN: EAACEM</identifier><language>eng</language><publisher>Netherlands: Springer Nature B.V</publisher><subject>Amino Acid Sequence ; amino acid sequences ; Animals ; antibacterial proteins ; antimicrobial peptides ; Defensins - biosynthesis ; Defensins - genetics ; Defensins - immunology ; developmental stages ; Female ; gene expression ; Gene Expression Profiling ; gene induction ; hematophagy ; Immune response ; Immune system ; Invertebrates ; Microorganisms ; midgut ; Molecular Sequence Data ; Ornithodoros - genetics ; Ornithodoros - immunology ; Ornithodoros - metabolism ; Ornithodoros moubata ; Protein Isoforms ; Sequence Alignment ; ticks ; tissue distribution</subject><ispartof>Experimental & applied acarology, 2002-01, Vol.28 (1-4), p.135-140</ispartof><rights>Copyright Science and Technology Letters 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-ad677439074baa7f17f743a78255e5e05f76104c65f9819fdce9069a6d6c0bda3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14570123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakajima, Y</creatorcontrib><creatorcontrib>Taylor, D</creatorcontrib><creatorcontrib>Yamakawa, M</creatorcontrib><title>Involvement of antibacterial peptide defensin in tick midgut defense</title><title>Experimental & applied acarology</title><addtitle>Exp Appl Acarol</addtitle><description>Animals are constantly threatened by pathogenic microorganisms and have developed cellular and humoral immune responses to combat these infections. Invertebrates possess only an innate non-specific immune response. Antimicrobial substances are major components of innate immunity not only in invertebrates but also in vertebrates. Despite the importance of ticks as vectors of disease very little is known about their immune system. Our recent studies have revealed that four defensin isoforms are present in Ornithodoros moubata. These four isoforms are constitutively expressed in the midgut and up-regulated in response to blood feeding. Moreover, a mature peptide of defensin isoform A has been isolated from the tick midgut lumen. These findings indicate Ornithodoros defensins are involved in tick midgut defense against potentially harmful invasive microbes.</description><subject>Amino Acid Sequence</subject><subject>amino acid sequences</subject><subject>Animals</subject><subject>antibacterial proteins</subject><subject>antimicrobial peptides</subject><subject>Defensins - biosynthesis</subject><subject>Defensins - genetics</subject><subject>Defensins - immunology</subject><subject>developmental stages</subject><subject>Female</subject><subject>gene expression</subject><subject>Gene Expression Profiling</subject><subject>gene induction</subject><subject>hematophagy</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Invertebrates</subject><subject>Microorganisms</subject><subject>midgut</subject><subject>Molecular Sequence Data</subject><subject>Ornithodoros - genetics</subject><subject>Ornithodoros - immunology</subject><subject>Ornithodoros - metabolism</subject><subject>Ornithodoros moubata</subject><subject>Protein Isoforms</subject><subject>Sequence Alignment</subject><subject>ticks</subject><subject>tissue distribution</subject><issn>0168-8162</issn><issn>1572-9702</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkctLBDEMxosouj7O3nTw4G00fbfexDcIHtRz6c6kUp3HOp0R_O-t7ILoRQh8JPzyhSSE7FM4ocD4qT_LIrm1ioIVeo3MqNSstBrYOpkBVaY0VLEtsp3SKwBIUHKTbFEhNVDGZ-Tyrvvomw9ssRuLPhS-G-PcVyMO0TfFAhdjrLGoMWCXYlfkGGP1VrSxfpnGVR13yUbwTcK9le6Q5-urp4vb8v7h5u7i_L6shKBj6WulteAWtJh7rwPVIadeGyYlSgQZdF5DVEoGa6gNdYUWlPWqVhXMa893yPHSdzH07xOm0bUxVdg0vsN-Sk4zS5m29l-QGmM05SaDR3_A134auryEYyyfTwilMnS6hKqhT2nA4BZDbP3w6Si47ze4c_frDbnjYGU7zVusf_jV3TNwuASC751_GWJyz495IAew3DAL_AtRj4oV</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Nakajima, Y</creator><creator>Taylor, D</creator><creator>Yamakawa, M</creator><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7T7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>Involvement of antibacterial peptide defensin in tick midgut defense</title><author>Nakajima, Y ; Taylor, D ; Yamakawa, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-ad677439074baa7f17f743a78255e5e05f76104c65f9819fdce9069a6d6c0bda3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Amino Acid Sequence</topic><topic>amino acid sequences</topic><topic>Animals</topic><topic>antibacterial proteins</topic><topic>antimicrobial peptides</topic><topic>Defensins - 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| subjects | Amino Acid Sequence amino acid sequences Animals antibacterial proteins antimicrobial peptides Defensins - biosynthesis Defensins - genetics Defensins - immunology developmental stages Female gene expression Gene Expression Profiling gene induction hematophagy Immune response Immune system Invertebrates Microorganisms midgut Molecular Sequence Data Ornithodoros - genetics Ornithodoros - immunology Ornithodoros - metabolism Ornithodoros moubata Protein Isoforms Sequence Alignment ticks tissue distribution |
| title | Involvement of antibacterial peptide defensin in tick midgut defense |
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