Phrenic and hypoglossal neural responses to cold airflow in the upper airway
Cold air flowing through the larynx is known to alter the activities of laryngeal receptors with afferents in the superior laryngeal nerves (SLNs) and to induce reflex apnea in neonatal mammals. To examine the ventilatory response in adult animals and to explore associated upper airway motor respons...
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| Veröffentlicht in: | Respiration physiology 1992-02, Vol.87 (2), p.157-164 |
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| creator | Ukabam, C.U. Knuth, S.L. Bartlett, D. |
| description | Cold air flowing through the larynx is known to alter the activities of laryngeal receptors with afferents in the superior laryngeal nerves (SLNs) and to induce reflex apnea in neonatal mammals. To examine the ventilatory response in adult animals and to explore associated upper airway motor responses, we recorded phrenic and hypoglossal neural responses to cooling the isolated larynx with cold air in decerebrate, vagotomized, paralyzed, ventillated cats. The most consistent response was phrenic inhibition, which occured in all animals tested. Either excitation or inhibition of hypoglossal activity was seen consistently in individual cats, with the result that the group response was not statistically significant. All responses to laryngeal cooling were abolished by section of the SLNs. The findings confirm that directing cold air through the larynx causes reflex inhibition of ventilatory (phrenic) activity, but raise new questions as to how the two, directionally opposite hypoglossal responses are mediated. |
| doi_str_mv | 10.1016/0034-5687(92)90056-3 |
| format | Article |
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To examine the ventilatory response in adult animals and to explore associated upper airway motor responses, we recorded phrenic and hypoglossal neural responses to cooling the isolated larynx with cold air in decerebrate, vagotomized, paralyzed, ventillated cats. The most consistent response was phrenic inhibition, which occured in all animals tested. Either excitation or inhibition of hypoglossal activity was seen consistently in individual cats, with the result that the group response was not statistically significant. All responses to laryngeal cooling were abolished by section of the SLNs. The findings confirm that directing cold air through the larynx causes reflex inhibition of ventilatory (phrenic) activity, but raise new questions as to how the two, directionally opposite hypoglossal responses are mediated.</description><identifier>ISSN: 0034-5687</identifier><identifier>DOI: 10.1016/0034-5687(92)90056-3</identifier><identifier>PMID: 1565889</identifier><identifier>CODEN: RSPYAK</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; cat ; Cats ; cold air ; Cold Temperature ; Denervation ; Female ; Fundamental and applied biological sciences. Psychology ; Hypoglossal Nerve - physiology ; Laryngeal Nerves - physiology ; Larynx - physiology ; Larynx reflex ; Male ; Mammals ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. 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To examine the ventilatory response in adult animals and to explore associated upper airway motor responses, we recorded phrenic and hypoglossal neural responses to cooling the isolated larynx with cold air in decerebrate, vagotomized, paralyzed, ventillated cats. The most consistent response was phrenic inhibition, which occured in all animals tested. Either excitation or inhibition of hypoglossal activity was seen consistently in individual cats, with the result that the group response was not statistically significant. All responses to laryngeal cooling were abolished by section of the SLNs. The findings confirm that directing cold air through the larynx causes reflex inhibition of ventilatory (phrenic) activity, but raise new questions as to how the two, directionally opposite hypoglossal responses are mediated.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>cat</subject><subject>Cats</subject><subject>cold air</subject><subject>Cold Temperature</subject><subject>Denervation</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypoglossal Nerve - physiology</subject><subject>Laryngeal Nerves - physiology</subject><subject>Larynx - physiology</subject><subject>Larynx reflex</subject><subject>Male</subject><subject>Mammals</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Motor nerves</subject><subject>neural responses</subject><subject>Phrenic Nerve - physiology</subject><subject>Pulmonary Ventilation</subject><subject>Upper airways</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0034-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhj2AoBT-AUgeEIIhYMexUy9IqOJLqgQDzJZjX6hRGgc7oeq_JyFV2ZhOd-97Xw9Cp5RcU0LFDSEsS7iY5ZcyvZKEcJGwPTTZlQ_RUYyfpM8FEQfogHLBZzM5QYvXZYDaGaxri5ebxn9UPkZd4Rq60IcAsfF1hIhbj42vLNYulJVfY1fjdgm4axoIQ3GtN8dov9RVhJNtnKL3h_u3-VOyeHl8nt8tEsMIbZOUaAoGQHMtOLWQcctSaUALzUueW2EtmDQDmzIoM1ZYA7QQhRYWJJuxnE3RxTi3Cf6rg9iqlYsGqkrX4Luo8lQSKYXojdloNKH_KkCpmuBWOmwUJWoApwZCaiCkZKp-wSnWt51t53fFCuxf00it18-3uo5GV2XQtXFxZ-OUyDQbtt-ONuhZfDsIKhoHtQHrAphWWe_-v-MHIv6NRQ</recordid><startdate>199202</startdate><enddate>199202</enddate><creator>Ukabam, C.U.</creator><creator>Knuth, S.L.</creator><creator>Bartlett, D.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199202</creationdate><title>Phrenic and hypoglossal neural responses to cold airflow in the upper airway</title><author>Ukabam, C.U. ; Knuth, S.L. ; Bartlett, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c301t-20a1eceea5a651de45d329cea6a5f57d6ddec24ed23ef43bdce1b6ba6de938373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>cat</topic><topic>Cats</topic><topic>cold air</topic><topic>Cold Temperature</topic><topic>Denervation</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypoglossal Nerve - physiology</topic><topic>Laryngeal Nerves - physiology</topic><topic>Larynx - physiology</topic><topic>Larynx reflex</topic><topic>Male</topic><topic>Mammals</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Motor nerves</topic><topic>neural responses</topic><topic>Phrenic Nerve - physiology</topic><topic>Pulmonary Ventilation</topic><topic>Upper airways</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>online_resources</toplevel><creatorcontrib>Ukabam, C.U.</creatorcontrib><creatorcontrib>Knuth, S.L.</creatorcontrib><creatorcontrib>Bartlett, D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiration physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ukabam, C.U.</au><au>Knuth, S.L.</au><au>Bartlett, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phrenic and hypoglossal neural responses to cold airflow in the upper airway</atitle><jtitle>Respiration physiology</jtitle><addtitle>Respir Physiol</addtitle><date>1992-02</date><risdate>1992</risdate><volume>87</volume><issue>2</issue><spage>157</spage><epage>164</epage><pages>157-164</pages><issn>0034-5687</issn><coden>RSPYAK</coden><abstract>Cold air flowing through the larynx is known to alter the activities of laryngeal receptors with afferents in the superior laryngeal nerves (SLNs) and to induce reflex apnea in neonatal mammals. To examine the ventilatory response in adult animals and to explore associated upper airway motor responses, we recorded phrenic and hypoglossal neural responses to cooling the isolated larynx with cold air in decerebrate, vagotomized, paralyzed, ventillated cats. The most consistent response was phrenic inhibition, which occured in all animals tested. Either excitation or inhibition of hypoglossal activity was seen consistently in individual cats, with the result that the group response was not statistically significant. All responses to laryngeal cooling were abolished by section of the SLNs. The findings confirm that directing cold air through the larynx causes reflex inhibition of ventilatory (phrenic) activity, but raise new questions as to how the two, directionally opposite hypoglossal responses are mediated.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1565889</pmid><doi>10.1016/0034-5687(92)90056-3</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences cat Cats cold air Cold Temperature Denervation Female Fundamental and applied biological sciences. Psychology Hypoglossal Nerve - physiology Laryngeal Nerves - physiology Larynx - physiology Larynx reflex Male Mammals Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Motor nerves neural responses Phrenic Nerve - physiology Pulmonary Ventilation Upper airways Vertebrates: nervous system and sense organs |
| title | Phrenic and hypoglossal neural responses to cold airflow in the upper airway |
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