Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors
Substituted 4-quinolone- (1, A = CH) and 1,8-naphthyrid-4-one- (1, A = N) 3-carboxylic acids are currently the only classes of clinically useful antibacterial agents exerting their activity by inhibiting the subunit A of DNA gyrase. Pyrimido[1,6-alpha]benzimidazoles 11 have been found to be a new cl...
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| Veröffentlicht in: | Journal of medicinal chemistry 1992-04, Vol.35 (8), p.1385-1392 |
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| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
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| container_end_page | 1392 |
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| container_issue | 8 |
| container_start_page | 1385 |
| container_title | Journal of medicinal chemistry |
| container_volume | 35 |
| creator | Hubschwerlen, C Pflieger, P Specklin, J L Gubernator, K Gmünder, H Angehrn, P Kompis, I |
| description | Substituted 4-quinolone- (1, A = CH) and 1,8-naphthyrid-4-one- (1, A = N) 3-carboxylic acids are currently the only classes of clinically useful antibacterial agents exerting their activity by inhibiting the subunit A of DNA gyrase. Pyrimido[1,6-alpha]benzimidazoles 11 have been found to be a new class of inhibitors of this enzyme. The design, synthesis, and biological activity of these compounds are reported. |
| doi_str_mv | 10.1021/jm00086a006 |
| format | Article |
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Pyrimido[1,6-alpha]benzimidazoles 11 have been found to be a new class of inhibitors of this enzyme. 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| fulltext | fulltext |
| identifier | ISSN: 0022-2623 |
| ispartof | Journal of medicinal chemistry, 1992-04, Vol.35 (8), p.1385-1392 |
| issn | 0022-2623 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72909773 |
| source | MEDLINE; ACS Publications |
| subjects | Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Benzimidazoles - pharmacology Enzyme Inhibitors - chemical synthesis Pyrimidinones - chemical synthesis Pyrimidinones - chemistry Pyrimidinones - pharmacology Structure-Activity Relationship Topoisomerase II Inhibitors |
| title | Pyrimido[1,6-a]benzimidazoles: a new class of DNA gyrase inhibitors |
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