Cellular responses to extracellular matrix
When the first experimental systems showing a biological effect of extracellular matrix on cells were presented about 20 years ago, for example, the stimulation of myoblast differentiation in culture by collagen [1], there was apparently no need for an exogenous matrix (ECM) control of cell differen...
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| Veröffentlicht in: | Kidney international 1992-03, Vol.41 (3), p.632-640 |
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| container_title | Kidney international |
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| creator | von der Mark, Klaus von der Mark, Helga Goodman, Simon |
| description | When the first experimental systems showing a biological effect of extracellular matrix on cells were presented about 20 years ago, for example, the stimulation of myoblast differentiation in culture by collagen [1], there was apparently no need for an exogenous matrix (ECM) control of cell differentiation—everything seemed to be determined by the genes, regulating all cellular events. For many years there was general scepticism about a specific role for the ECM in cell development and differentiation. How could such large macromolecules, many of which hadn't even been structurally characterized, exert specific effects on cells, and how would cells be able to recognize matrix molecules? |
| doi_str_mv | 10.1038/ki.1992.97 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Kidney international, 1992-03, Vol.41 (3), p.632-640 |
| issn | 0085-2538 1523-1755 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72909462 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Cell Adhesion Cell Division Cell Movement Collagen - chemistry Collagen - physiology Extracellular Matrix - chemistry Extracellular Matrix - physiology Fibronectins - chemistry Fibronectins - physiology Laminin - chemistry Laminin - physiology |
| title | Cellular responses to extracellular matrix |
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