DNA image cytometry : a prognostic tool in rectal cancer ?
In 68 patients the DNA content of tumor cells was measured by image cytometry after resection of the rectum because of cancer. In the DNA histogram a differentiation between diploid (n = 19), polyploid (n = 24), hypotriploid (n = 17), and hypertriploid (n = 8) tumors was possible. The best relapse-f...
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| Veröffentlicht in: | Diseases of the colon & rectum 1992-05, Vol.35 (5), p.436-443 |
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| container_issue | 5 |
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| container_title | Diseases of the colon & rectum |
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| creator | BÖTTGER, T. C GABBERT, H. E STÖCKLE, M WELLEK, S HILS, R HEINTZ, A JUNGINGER, T |
| description | In 68 patients the DNA content of tumor cells was measured by image cytometry after resection of the rectum because of cancer. In the DNA histogram a differentiation between diploid (n = 19), polyploid (n = 24), hypotriploid (n = 17), and hypertriploid (n = 8) tumors was possible. The best relapse-free survival time was found in patients with diploid tumors. The prognosis worsened from polyploid to hypotriploid and was worse in hypertriploid tumors. Testing for a prognostic advantage of diploid over aneuploid tumors without adjustment for additional factors simply by means of the log-rank statistic gave a (one-sided) P of 0.1013. In a multivariate analysis the degree of differentiation turned out most important. Again, an appropriate test for prognostic relevance of DNA content failed to be significant (P = 0.3264). |
| doi_str_mv | 10.1007/bf02049399 |
| format | Article |
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| ispartof | Diseases of the colon & rectum, 1992-05, Vol.35 (5), p.436-443 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Analysis of Variance Biological and medical sciences Computer Simulation Cytophotometry - methods DNA, Neoplasm - analysis Female Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Middle Aged Neoplasm Recurrence, Local Ploidies Prognosis Rectal Neoplasms - genetics Rectal Neoplasms - pathology Risk Factors Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | DNA image cytometry : a prognostic tool in rectal cancer ? |
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