Plasminogen activators and inhibitors in normal late pregnancy, postpartum and in the postnatal period
Tissue plasminogen activator (t-PA), urokinase plasminogen activator (u-PA) and plasminogen activator inhibitors (PAI) are elevated in late pregnancy with t-PA and u-PA remaining so at 6 weeks postnatal. PAI-2 remains at postpartum but was absent by 6 weeks postnatal unlike PAI activity which was ab...
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| Veröffentlicht in: | International journal of gynecology and obstetrics 1992-05, Vol.38 (1), p.9-18 |
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| container_title | International journal of gynecology and obstetrics |
| container_volume | 38 |
| creator | Koh, C.L.S. Viegas, O.A.C. Yuen, R. Chua, S.E. Ng, B.L. Ratnam, S.S. |
| description | Tissue plasminogen activator (t-PA), urokinase plasminogen activator (u-PA) and plasminogen activator inhibitors (PAI) are elevated in late pregnancy with t-PA and u-PA remaining so at 6 weeks postnatal. PAI-2 remains at postpartum but was absent by 6 weeks postnatal unlike PAI activity which was absent at postpartum and returned to nonpregnant level at postnatal. The potential fibrinolytic response to stress is much reduced in pregnancy thus increasing the risk of thromboembolism. |
| doi_str_mv | 10.1016/0020-7292(92)90723-V |
| format | Article |
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PAI-2 remains at postpartum but was absent by 6 weeks postnatal unlike PAI activity which was absent at postpartum and returned to nonpregnant level at postnatal. The potential fibrinolytic response to stress is much reduced in pregnancy thus increasing the risk of thromboembolism.</description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1016/0020-7292(92)90723-V</identifier><identifier>PMID: 1348996</identifier><identifier>CODEN: IJGOAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Biological and medical sciences ; Electrophoresis, Polyacrylamide Gel ; Female ; Fibrinolysis - physiology ; Gynecology. Andrology. Obstetrics ; Humans ; Management. Prenatal diagnosis ; Medical sciences ; Plasminogen activator inhibitors ; Plasminogen Inactivators - blood ; Postpartum Period - blood ; Pregnancy ; Pregnancy - blood ; Pregnancy. Fetus. Placenta ; Serum Globulins - metabolism ; Tissue plasminogen activator ; Tissue Plasminogen Activator - blood ; Urokinase plasminogen activator ; Urokinase-Type Plasminogen Activator - blood</subject><ispartof>International journal of gynecology and obstetrics, 1992-05, Vol.38 (1), p.9-18</ispartof><rights>1992</rights><rights>1992 International Federation of Gynecology and Obstetrics</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4349-ac6f56593872fddf70fb3ae11c8cc68e6aea018d903c081fc7c270635bd80b123</citedby><cites>FETCH-LOGICAL-c4349-ac6f56593872fddf70fb3ae11c8cc68e6aea018d903c081fc7c270635bd80b123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2F0020-7292%2892%2990723-V$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/0020-7292(92)90723-V$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,1417,3550,27924,27925,45574,45575,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5275609$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1348996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koh, C.L.S.</creatorcontrib><creatorcontrib>Viegas, O.A.C.</creatorcontrib><creatorcontrib>Yuen, R.</creatorcontrib><creatorcontrib>Chua, S.E.</creatorcontrib><creatorcontrib>Ng, B.L.</creatorcontrib><creatorcontrib>Ratnam, S.S.</creatorcontrib><title>Plasminogen activators and inhibitors in normal late pregnancy, postpartum and in the postnatal period</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description>Tissue plasminogen activator (t-PA), urokinase plasminogen activator (u-PA) and plasminogen activator inhibitors (PAI) are elevated in late pregnancy with t-PA and u-PA remaining so at 6 weeks postnatal. PAI-2 remains at postpartum but was absent by 6 weeks postnatal unlike PAI activity which was absent at postpartum and returned to nonpregnant level at postnatal. The potential fibrinolytic response to stress is much reduced in pregnancy thus increasing the risk of thromboembolism.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Female</subject><subject>Fibrinolysis - physiology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Plasminogen activator inhibitors</subject><subject>Plasminogen Inactivators - blood</subject><subject>Postpartum Period - blood</subject><subject>Pregnancy</subject><subject>Pregnancy - blood</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Serum Globulins - metabolism</subject><subject>Tissue plasminogen activator</subject><subject>Tissue Plasminogen Activator - blood</subject><subject>Urokinase plasminogen activator</subject><subject>Urokinase-Type Plasminogen Activator - blood</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1rFTEQhoMo9bT6DxT2QkTBrZPsRzY3gpTaDwr1Qnsbssmkjewma5JTOf_e3e6hvRMhEDLzvDPkIeQNhWMKtP0MwKDkTLAPgn0UwFlV3jwjG9pxUVY1F8_J5hF5SQ5T-gUAlFN6QA5oVXdCtBtivw8qjc6HW_SF0tndqxxiKpQ3hfN3rncPT-cLH-KohmJQGYsp4q1XXu8-FVNIeVIxb8d9psh3-FD1Ks_8hNEF84q8sGpI-Hp_H5Gf305_nJyXV9dnFydfr0pdV7UolW5t0zai6jizxlgOtq8UUqo7rdsOW4UKaGcEVBo6ajXXjENbNb3poKesOiLv17lTDL-3mLIcXdI4DMpj2CY5uwDeAJ3BegV1DClFtHKKblRxJynIRa9c3C08k8tZ9MqbOfZ2P3_bj2ieQqvPuf9u31dJq8HGWZJLj1jDeNOCmDG-Yn_cgLv_Wi0vLs-ul-SXNYmzxXuHUSbt0Gs0LqLO0gT37x_8BZ6TqG4</recordid><startdate>199205</startdate><enddate>199205</enddate><creator>Koh, C.L.S.</creator><creator>Viegas, O.A.C.</creator><creator>Yuen, R.</creator><creator>Chua, S.E.</creator><creator>Ng, B.L.</creator><creator>Ratnam, S.S.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199205</creationdate><title>Plasminogen activators and inhibitors in normal late pregnancy, postpartum and in the postnatal period</title><author>Koh, C.L.S. ; Viegas, O.A.C. ; Yuen, R. ; Chua, S.E. ; Ng, B.L. ; Ratnam, S.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4349-ac6f56593872fddf70fb3ae11c8cc68e6aea018d903c081fc7c270635bd80b123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Female</topic><topic>Fibrinolysis - physiology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Plasminogen activator inhibitors</topic><topic>Plasminogen Inactivators - blood</topic><topic>Postpartum Period - blood</topic><topic>Pregnancy</topic><topic>Pregnancy - blood</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Serum Globulins - metabolism</topic><topic>Tissue plasminogen activator</topic><topic>Tissue Plasminogen Activator - blood</topic><topic>Urokinase plasminogen activator</topic><topic>Urokinase-Type Plasminogen Activator - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koh, C.L.S.</creatorcontrib><creatorcontrib>Viegas, O.A.C.</creatorcontrib><creatorcontrib>Yuen, R.</creatorcontrib><creatorcontrib>Chua, S.E.</creatorcontrib><creatorcontrib>Ng, B.L.</creatorcontrib><creatorcontrib>Ratnam, S.S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koh, C.L.S.</au><au>Viegas, O.A.C.</au><au>Yuen, R.</au><au>Chua, S.E.</au><au>Ng, B.L.</au><au>Ratnam, S.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasminogen activators and inhibitors in normal late pregnancy, postpartum and in the postnatal period</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>1992-05</date><risdate>1992</risdate><volume>38</volume><issue>1</issue><spage>9</spage><epage>18</epage><pages>9-18</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><coden>IJGOAL</coden><abstract>Tissue plasminogen activator (t-PA), urokinase plasminogen activator (u-PA) and plasminogen activator inhibitors (PAI) are elevated in late pregnancy with t-PA and u-PA remaining so at 6 weeks postnatal. PAI-2 remains at postpartum but was absent by 6 weeks postnatal unlike PAI activity which was absent at postpartum and returned to nonpregnant level at postnatal. The potential fibrinolytic response to stress is much reduced in pregnancy thus increasing the risk of thromboembolism.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>1348996</pmid><doi>10.1016/0020-7292(92)90723-V</doi><tpages>10</tpages></addata></record> |
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| ispartof | International journal of gynecology and obstetrics, 1992-05, Vol.38 (1), p.9-18 |
| issn | 0020-7292 1879-3479 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library; Access via ScienceDirect (Elsevier) |
| subjects | Adult Biological and medical sciences Electrophoresis, Polyacrylamide Gel Female Fibrinolysis - physiology Gynecology. Andrology. Obstetrics Humans Management. Prenatal diagnosis Medical sciences Plasminogen activator inhibitors Plasminogen Inactivators - blood Postpartum Period - blood Pregnancy Pregnancy - blood Pregnancy. Fetus. Placenta Serum Globulins - metabolism Tissue plasminogen activator Tissue Plasminogen Activator - blood Urokinase plasminogen activator Urokinase-Type Plasminogen Activator - blood |
| title | Plasminogen activators and inhibitors in normal late pregnancy, postpartum and in the postnatal period |
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