Binding parameters and idiotypic profile of the whole immunoglobulin and Fab' fragments of murine monoclonal antibody to distinct determinants of the human high molecular weight-melanoma associated antigen

The nonspecific accumulation of radioactivity in bone marrow, liver, and spleen in patients with melanoma injected with radiolabeled whole IgG of anti-high molecular weight-melanoma associated antigen (HMW-MAA) monoclonal antibody (mAb) hampers the application of immunoscintigraphy to visualize mela...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1992-05, Vol.52 (9), p.2497-2503
Hauptverfasser:	Temponi, M, Gold, A M, Ferrone, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - metabolism Antigens, Neoplasm Epitopes - metabolism Humans Immunoglobulin Fab Fragments - metabolism Immunoglobulin G - metabolism Iodine Radioisotopes - metabolism Melanoma - immunology Melanoma - metabolism Melanoma-Specific Antigens Neoplasm Proteins - metabolism Precipitin Tests
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