Chronic Hypoxia Changes the Ratio of Endothelin to ATP Release from Rat Aortic Endothelial Cells Exposed to High Flow

Endothelial cells isolated from the thoracic aorta of normoxic and chronically hypoxic rats were perfused (0.5 ml min-1) and stimulated by increased flow rate (3.0 ml min-1). The release of ATP, endothelin and vasopressin was investigated. During periods of high flow rate, endothelial cells isolated...

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Veröffentlicht in:	Proceedings of the Royal Society. B, Biological sciences Biological sciences, 1992-02, Vol.247 (1319), p.131-135
Hauptverfasser:	Bodin, Philippe, Milner, Pamela, Winter, Robert, Burnstock, Geoffrey
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - secretion Animals Antiserum Aorta Aorta, Thoracic - cytology Aorta, Thoracic - secretion Dilatation Endothelial cells Endothelins Endothelins - secretion Endothelium, Vascular - cytology Endothelium, Vascular - secretion Flow velocity Hypoxia Hypoxia - physiopathology In Vitro Techniques Male Rats Rats, Inbred Strains Thoracic aorta Vasoconstriction - physiology Vasoconstrictors Vasodilation - physiology Vasodilators
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