Changes in spirometry during consecutive admissions for infective pulmonary exacerbations in adolescent and adult cystic fibrosis

Changes in spirometry during consecutive admissions for treatment of pulmonary infective exacerbations were studied in 45 patients (24 males, 21 females) with cystic fibrosis (CF) who had required five or more such admissions. Over the overall study period there was a mean (SD) decline in FEV1 of -1...

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Veröffentlicht in:	Respiratory medicine 1992, Vol.86 (1), p.45-48
Hauptverfasser:	PACKE, G. E, HODSON, M. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Bacterial Infections - physiopathology Biological and medical sciences Cystic Fibrosis - physiopathology Female Forced Expiratory Volume - physiology Gastroenterology. Liver. Pancreas. Abdomen Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Lung - physiopathology Lung Diseases - microbiology Male Medical sciences Other diseases. Semiology Recurrence Spirometry Time Factors Vital Capacity - physiology
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creator	PACKE, G. E HODSON, M. E
description	Changes in spirometry during consecutive admissions for treatment of pulmonary infective exacerbations were studied in 45 patients (24 males, 21 females) with cystic fibrosis (CF) who had required five or more such admissions. Over the overall study period there was a mean (SD) decline in FEV1 of -112.1 (188.0) ml yr-1 (P less than 0.001) and in FVC of -47.9 (82.4) ml yr-1 (P less than 0.001). FEV1 and FVC increased during each admission with treatment; however, the magnitude of this change became less over consecutive admissions by a mean value of -33.3 ml (45.0) (P less than 0.001) for FEV1, and -26.0 (72.2) ml (P less than 0.05) for FVC. In the majority of patients that died or underwent transplantation, FEV1 at the time of the last admission did not rise above 800 ml despite full treatment.
doi_str_mv	10.1016/S0954-6111(06)80147-2
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In the majority of patients that died or underwent transplantation, FEV1 at the time of the last admission did not rise above 800 ml despite full treatment.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/S0954-6111(06)80147-2</identifier><identifier>PMID: 1565817</identifier><language>eng</language><publisher>Oxford: Elsevier</publisher><subject>Adolescent ; Adult ; Bacterial Infections - physiopathology ; Biological and medical sciences ; Cystic Fibrosis - physiopathology ; Female ; Forced Expiratory Volume - physiology ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Lung - physiopathology ; Lung Diseases - microbiology ; Male ; Medical sciences ; Other diseases. 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E</creatorcontrib><title>Changes in spirometry during consecutive admissions for infective pulmonary exacerbations in adolescent and adult cystic fibrosis</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Changes in spirometry during consecutive admissions for treatment of pulmonary infective exacerbations were studied in 45 patients (24 males, 21 females) with cystic fibrosis (CF) who had required five or more such admissions. Over the overall study period there was a mean (SD) decline in FEV1 of -112.1 (188.0) ml yr-1 (P less than 0.001) and in FVC of -47.9 (82.4) ml yr-1 (P less than 0.001). FEV1 and FVC increased during each admission with treatment; however, the magnitude of this change became less over consecutive admissions by a mean value of -33.3 ml (45.0) (P less than 0.001) for FEV1, and -26.0 (72.2) ml (P less than 0.05) for FVC. In the majority of patients that died or underwent transplantation, FEV1 at the time of the last admission did not rise above 800 ml despite full treatment.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Bacterial Infections - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Cystic Fibrosis - physiopathology</subject><subject>Female</subject><subject>Forced Expiratory Volume - physiology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Lung - physiopathology</subject><subject>Lung Diseases - microbiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Other diseases. 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E</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Changes in spirometry during consecutive admissions for infective pulmonary exacerbations in adolescent and adult cystic fibrosis</title><author>PACKE, G. E ; HODSON, M. E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p167t-ebb2b781ff77fb00931422d7c3153f174b4a4fef077da9a5561af03adf9a8fbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Bacterial Infections - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Cystic Fibrosis - physiopathology</topic><topic>Female</topic><topic>Forced Expiratory Volume - physiology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Lung - physiopathology</topic><topic>Lung Diseases - microbiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Recurrence</topic><topic>Spirometry</topic><topic>Time Factors</topic><topic>Vital Capacity - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PACKE, G. E</creatorcontrib><creatorcontrib>HODSON, M. E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PACKE, G. E</au><au>HODSON, M. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in spirometry during consecutive admissions for infective pulmonary exacerbations in adolescent and adult cystic fibrosis</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>1992</date><risdate>1992</risdate><volume>86</volume><issue>1</issue><spage>45</spage><epage>48</epage><pages>45-48</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Changes in spirometry during consecutive admissions for treatment of pulmonary infective exacerbations were studied in 45 patients (24 males, 21 females) with cystic fibrosis (CF) who had required five or more such admissions. Over the overall study period there was a mean (SD) decline in FEV1 of -112.1 (188.0) ml yr-1 (P less than 0.001) and in FVC of -47.9 (82.4) ml yr-1 (P less than 0.001). FEV1 and FVC increased during each admission with treatment; however, the magnitude of this change became less over consecutive admissions by a mean value of -33.3 ml (45.0) (P less than 0.001) for FEV1, and -26.0 (72.2) ml (P less than 0.05) for FVC. In the majority of patients that died or underwent transplantation, FEV1 at the time of the last admission did not rise above 800 ml despite full treatment.</abstract><cop>Oxford</cop><pub>Elsevier</pub><pmid>1565817</pmid><doi>10.1016/S0954-6111(06)80147-2</doi><tpages>4</tpages></addata></record>
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subjects	Adolescent Adult Bacterial Infections - physiopathology Biological and medical sciences Cystic Fibrosis - physiopathology Female Forced Expiratory Volume - physiology Gastroenterology. Liver. Pancreas. Abdomen Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Lung - physiopathology Lung Diseases - microbiology Male Medical sciences Other diseases. Semiology Recurrence Spirometry Time Factors Vital Capacity - physiology
title	Changes in spirometry during consecutive admissions for infective pulmonary exacerbations in adolescent and adult cystic fibrosis
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