Expression of cytokine genes in blood mononuclear cells in women with pyoinflammatory diseases of adnexa uteri
Production of interleukin, interferon-gamma, and transforming growth beta(2)-factor mRNA in peripheral blood mononuclear cells was studied in women with pyoinflammatory diseases of adnexa uteri. Predominant expression of Th1 proinflammatory cytokine genes in patients was demonstrated. Production of...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2002-11, Vol.134 (5), p.477-481 |
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| container_end_page | 481 |
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| container_issue | 5 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Zhdanov, A V Sosulina, L Yu Kurbanova, D F Van'ko, L V Sukhikh, G T |
| description | Production of interleukin, interferon-gamma, and transforming growth beta(2)-factor mRNA in peripheral blood mononuclear cells was studied in women with pyoinflammatory diseases of adnexa uteri. Predominant expression of Th1 proinflammatory cytokine genes in patients was demonstrated. Production of interleukins 4 and 8 mRNA decreased 200- and 60-fold, respectively, in comparison with that in healthy women. One month and a half after extirpation of fallopian tubes the cytokine production in blood mononuclear cells shifted towards antiinflammatory cytokines, expression of interleukin-8 gene returned to normal, and expression of interleukin-4 gene increased. |
| doi_str_mv | 10.1023/A:1022602700520 |
| format | Article |
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Predominant expression of Th1 proinflammatory cytokine genes in patients was demonstrated. Production of interleukins 4 and 8 mRNA decreased 200- and 60-fold, respectively, in comparison with that in healthy women. 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| subjects | Adult Base Sequence Case-Control Studies Cytokines - genetics DNA - genetics Female Gene Expression Humans Interleukin-4 - genetics Interleukin-8 - genetics Leukocytes, Mononuclear - immunology Pelvic Inflammatory Disease - genetics Pelvic Inflammatory Disease - immunology Pelvic Inflammatory Disease - therapy Th1 Cells - immunology Th2 Cells - immunology |
| title | Expression of cytokine genes in blood mononuclear cells in women with pyoinflammatory diseases of adnexa uteri |
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