Genetic targeting of cerebellar Purkinje cells: history, current status and novel strategies
This review is an account of developments in the field of transgenic and gene targeting approaches with special emphasis on the cerebellar Purkinje cell. A critical discussion of the available genetic tools is provided. As genetic engineering of the mouse is still a rapidly moving field, we felt it...
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| Veröffentlicht in: | Cerebellum (London, England) England), 2002-04, Vol.1 (2), p.111-118 |
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| container_title | Cerebellum (London, England) |
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| creator | Barski, Jaroslaw J Lauth, Matthias Meyer, Michael |
| description | This review is an account of developments in the field of transgenic and gene targeting approaches with special emphasis on the cerebellar Purkinje cell. A critical discussion of the available genetic tools is provided. As genetic engineering of the mouse is still a rapidly moving field, we felt it appropriate to include some ideas on novel strategies for refined genetic manipulations. |
| doi_str_mv | 10.1080/147342202753671240 |
| format | Article |
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| ispartof | Cerebellum (London, England), 2002-04, Vol.1 (2), p.111-118 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Animals, Genetically Modified - metabolism Animals, Genetically Modified - physiology Cerebellum Gene Deletion Gene targeting Gene Targeting - methods Genetic engineering Humans Purkinje cells Purkinje Cells - metabolism Purkinje Cells - physiology Recombination, Genetic Recovery of Function - genetics Transgenes - physiology |
| title | Genetic targeting of cerebellar Purkinje cells: history, current status and novel strategies |
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