IL-28, IL-29 and their class II cytokine receptor IL-28R
Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 fami...
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| Veröffentlicht in: | Nature immunology 2003-01, Vol.4 (1), p.63-68 |
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| container_title | Nature immunology |
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| creator | Sheppard, Paul Kindsvogel, Wayne Xu, Wenfeng Henderson, Katherine Schlutsmeyer, Stacy Whitmore, Theodore E. Kuestner, Rolf Garrigues, Ursula Birks, Carl Roraback, Jenny Ostrander, Craig Dong, Dennis Shin, Jinu Presnell, Scott Fox, Brian Haldeman, Betty Cooper, Emily Taft, David Gilbert, Teresa Grant, Francis J. Tackett, Monica Krivan, William McKnight, Gary Clegg, Chris Foster, Don Klucher, Kevin M. |
| description | Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by viral infection and showed antiviral activity. However, IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor β (IL-10Rβ) and an orphan class II receptor chain, designated IL-28Rα. This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection. |
| doi_str_mv | 10.1038/ni873 |
| format | Article |
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Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by viral infection and showed antiviral activity. However, IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor β (IL-10Rβ) and an orphan class II receptor chain, designated IL-28Rα. This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection.</description><identifier>ISSN: 1529-2908</identifier><identifier>EISSN: 1529-2916</identifier><identifier>DOI: 10.1038/ni873</identifier><identifier>PMID: 12469119</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Amino Acid Sequence ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Cloning, Molecular ; COS Cells ; Cytokines ; Gene Expression ; Humans ; Immunology ; In Vitro Techniques ; Infectious Diseases ; Interferons ; Interleukins - genetics ; Interleukins - metabolism ; Molecular Sequence Data ; Protein Subunits ; Receptors, Cytokine - chemistry ; Receptors, Cytokine - genetics ; Receptors, Cytokine - metabolism ; Recombinant Proteins - chemistry ; Recombinant Proteins - genetics ; Recombinant Proteins - metabolism ; RNA - genetics ; RNA - metabolism ; Sequence Homology, Amino Acid ; Signal Transduction ; Virus Diseases - immunology</subject><ispartof>Nature immunology, 2003-01, Vol.4 (1), p.63-68</ispartof><rights>Springer Nature America, Inc. 2002</rights><rights>COPYRIGHT 2003 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-bbb82c78a6a4dd1032c3c130a39b059e2cbb420b2572e7d48cc3a22b00f040ea3</citedby><cites>FETCH-LOGICAL-c435t-bbb82c78a6a4dd1032c3c130a39b059e2cbb420b2572e7d48cc3a22b00f040ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ni873$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ni873$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12469119$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sheppard, Paul</creatorcontrib><creatorcontrib>Kindsvogel, Wayne</creatorcontrib><creatorcontrib>Xu, Wenfeng</creatorcontrib><creatorcontrib>Henderson, Katherine</creatorcontrib><creatorcontrib>Schlutsmeyer, Stacy</creatorcontrib><creatorcontrib>Whitmore, Theodore E.</creatorcontrib><creatorcontrib>Kuestner, Rolf</creatorcontrib><creatorcontrib>Garrigues, Ursula</creatorcontrib><creatorcontrib>Birks, Carl</creatorcontrib><creatorcontrib>Roraback, Jenny</creatorcontrib><creatorcontrib>Ostrander, Craig</creatorcontrib><creatorcontrib>Dong, Dennis</creatorcontrib><creatorcontrib>Shin, Jinu</creatorcontrib><creatorcontrib>Presnell, Scott</creatorcontrib><creatorcontrib>Fox, Brian</creatorcontrib><creatorcontrib>Haldeman, Betty</creatorcontrib><creatorcontrib>Cooper, Emily</creatorcontrib><creatorcontrib>Taft, David</creatorcontrib><creatorcontrib>Gilbert, Teresa</creatorcontrib><creatorcontrib>Grant, Francis J.</creatorcontrib><creatorcontrib>Tackett, Monica</creatorcontrib><creatorcontrib>Krivan, William</creatorcontrib><creatorcontrib>McKnight, Gary</creatorcontrib><creatorcontrib>Clegg, Chris</creatorcontrib><creatorcontrib>Foster, Don</creatorcontrib><creatorcontrib>Klucher, Kevin M.</creatorcontrib><title>IL-28, IL-29 and their class II cytokine receptor IL-28R</title><title>Nature immunology</title><addtitle>Nat Immunol</addtitle><addtitle>Nat Immunol</addtitle><description>Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by viral infection and showed antiviral activity. However, IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor β (IL-10Rβ) and an orphan class II receptor chain, designated IL-28Rα. This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cloning, Molecular</subject><subject>COS Cells</subject><subject>Cytokines</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Immunology</subject><subject>In Vitro Techniques</subject><subject>Infectious Diseases</subject><subject>Interferons</subject><subject>Interleukins - genetics</subject><subject>Interleukins - metabolism</subject><subject>Molecular Sequence Data</subject><subject>Protein Subunits</subject><subject>Receptors, Cytokine - chemistry</subject><subject>Receptors, Cytokine - genetics</subject><subject>Receptors, Cytokine - metabolism</subject><subject>Recombinant Proteins - chemistry</subject><subject>Recombinant Proteins - genetics</subject><subject>Recombinant Proteins - metabolism</subject><subject>RNA - genetics</subject><subject>RNA - metabolism</subject><subject>Sequence Homology, Amino Acid</subject><subject>Signal Transduction</subject><subject>Virus Diseases - immunology</subject><issn>1529-2908</issn><issn>1529-2916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkVtLwzAUx4MozttXkCIoCHbm1jZ5HMNLYSB4eQ5Jejo7u3YmLei3N7vgmC-ShxOSX07Ojz9CZwQPCWbitqlExvbQEUmojKkk6f7vHosBOvZ-hjHhWcoP0YBQnkpC5BES-SSm4iZaFhnppoi6d6hcZGvtfZTnkf3u2o-qgciBhUXXuhUqnk_RQalrD2ebeoLe7u9ex4_x5OkhH48mseUs6WJjjKA2EzrVvCjCpNQySxjWTBqcSKDWGE6xoUlGISu4sJZpSg3GJeYYNDtBV-u-C9d-9uA7Na-8hbrWDbS9V1nwC178X5CINEmxSAJ48Qectb1rgoSiFJNEJtkSGq6hqa5BVU3Zdk7bsAqYV7ZtoKzC-YgIIbBgcvn99c6DwHTw1U11773KX5532cs1a13rvYNSLVw11-5bEayWaapVmoE730zamzkUW2oT39bZh6tmCm6rstvpB5MFoCM</recordid><startdate>20030101</startdate><enddate>20030101</enddate><creator>Sheppard, Paul</creator><creator>Kindsvogel, Wayne</creator><creator>Xu, Wenfeng</creator><creator>Henderson, Katherine</creator><creator>Schlutsmeyer, Stacy</creator><creator>Whitmore, Theodore E.</creator><creator>Kuestner, Rolf</creator><creator>Garrigues, Ursula</creator><creator>Birks, Carl</creator><creator>Roraback, Jenny</creator><creator>Ostrander, Craig</creator><creator>Dong, Dennis</creator><creator>Shin, Jinu</creator><creator>Presnell, Scott</creator><creator>Fox, Brian</creator><creator>Haldeman, Betty</creator><creator>Cooper, Emily</creator><creator>Taft, David</creator><creator>Gilbert, Teresa</creator><creator>Grant, Francis J.</creator><creator>Tackett, Monica</creator><creator>Krivan, William</creator><creator>McKnight, Gary</creator><creator>Clegg, Chris</creator><creator>Foster, Don</creator><creator>Klucher, Kevin M.</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20030101</creationdate><title>IL-28, IL-29 and their class II cytokine receptor IL-28R</title><author>Sheppard, Paul ; Kindsvogel, Wayne ; Xu, Wenfeng ; Henderson, Katherine ; Schlutsmeyer, Stacy ; Whitmore, Theodore E. ; Kuestner, Rolf ; Garrigues, Ursula ; Birks, Carl ; Roraback, Jenny ; Ostrander, Craig ; Dong, Dennis ; Shin, Jinu ; Presnell, Scott ; Fox, Brian ; Haldeman, Betty ; Cooper, Emily ; Taft, David ; Gilbert, Teresa ; Grant, Francis J. ; Tackett, Monica ; Krivan, William ; McKnight, Gary ; Clegg, Chris ; Foster, Don ; Klucher, Kevin M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-bbb82c78a6a4dd1032c3c130a39b059e2cbb420b2572e7d48cc3a22b00f040ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cloning, Molecular</topic><topic>COS Cells</topic><topic>Cytokines</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Immunology</topic><topic>In Vitro Techniques</topic><topic>Infectious Diseases</topic><topic>Interferons</topic><topic>Interleukins - 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Academic</collection><jtitle>Nature immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sheppard, Paul</au><au>Kindsvogel, Wayne</au><au>Xu, Wenfeng</au><au>Henderson, Katherine</au><au>Schlutsmeyer, Stacy</au><au>Whitmore, Theodore E.</au><au>Kuestner, Rolf</au><au>Garrigues, Ursula</au><au>Birks, Carl</au><au>Roraback, Jenny</au><au>Ostrander, Craig</au><au>Dong, Dennis</au><au>Shin, Jinu</au><au>Presnell, Scott</au><au>Fox, Brian</au><au>Haldeman, Betty</au><au>Cooper, Emily</au><au>Taft, David</au><au>Gilbert, Teresa</au><au>Grant, Francis J.</au><au>Tackett, Monica</au><au>Krivan, William</au><au>McKnight, Gary</au><au>Clegg, Chris</au><au>Foster, Don</au><au>Klucher, Kevin M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IL-28, IL-29 and their class II cytokine receptor IL-28R</atitle><jtitle>Nature immunology</jtitle><stitle>Nat Immunol</stitle><addtitle>Nat Immunol</addtitle><date>2003-01-01</date><risdate>2003</risdate><volume>4</volume><issue>1</issue><spage>63</spage><epage>68</epage><pages>63-68</pages><issn>1529-2908</issn><eissn>1529-2916</eissn><abstract>Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by viral infection and showed antiviral activity. However, IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor β (IL-10Rβ) and an orphan class II receptor chain, designated IL-28Rα. This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>12469119</pmid><doi>10.1038/ni873</doi><tpages>6</tpages></addata></record> |
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| ispartof | Nature immunology, 2003-01, Vol.4 (1), p.63-68 |
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| source | MEDLINE; SpringerLink Journals; Nature Journals Online |
| subjects | Amino Acid Sequence Animals Biomedical and Life Sciences Biomedicine Cloning, Molecular COS Cells Cytokines Gene Expression Humans Immunology In Vitro Techniques Infectious Diseases Interferons Interleukins - genetics Interleukins - metabolism Molecular Sequence Data Protein Subunits Receptors, Cytokine - chemistry Receptors, Cytokine - genetics Receptors, Cytokine - metabolism Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism RNA - genetics RNA - metabolism Sequence Homology, Amino Acid Signal Transduction Virus Diseases - immunology |
| title | IL-28, IL-29 and their class II cytokine receptor IL-28R |
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