Cutaneous lupus erythematosus without systemic lupus erythematosus: Clinical and laboratory features
Sixty-seven patients with cutaneous lupus erythematosus (CLE) were followed up as part of a series of 570 lupus erythematosus patients seen in a private practice between 1980 and 1989. Clinical and laboratory features, treatment, and natural course were observed. Findings of interest included (1) a...
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| Veröffentlicht in: | Seminars in arthritis and rheumatism 1992-02, Vol.21 (4), p.221-226 |
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| container_title | Seminars in arthritis and rheumatism |
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| creator | Wallace, Daniel J. Pistiner, Moshe Nessim, Sharon Metzger, Allan L. Klinenberg, James R. |
| description | Sixty-seven patients with cutaneous lupus erythematosus (CLE) were followed up as part of a series of 570 lupus erythematosus patients seen in a private practice between 1980 and 1989. Clinical and laboratory features, treatment, and natural course were observed. Findings of interest included (1) a ratio of at least one CLE case for every seven cases of systemic lupus erythematosus (SLE); (2) occurrence of CLE in fewer women and apparently associated with an older age at diagnosis than SLE; (3) similar frequency of cutaneous lupus subsets in CLE and SLE; (4) strong family history for SLE but not CLE in CLE patients; (5) other cutaneous and musculoskeletal features in a majority of CLE patients and constitutional symptoms in 10%; (6) positive ANA titers, high sedimentation rates, and leukopenia common in CLE; (7) anticardiolipin antibody in 31% of CLE patients but not associated with systemic complications; (8) antimalarials required by 75% of patients and systemic steroids by 33%; and (9) an excellent prognosis associated with CLE, organ-threatening disease being rare. |
| doi_str_mv | 10.1016/0049-0172(92)90052-F |
| format | Article |
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Clinical and laboratory features, treatment, and natural course were observed. Findings of interest included (1) a ratio of at least one CLE case for every seven cases of systemic lupus erythematosus (SLE); (2) occurrence of CLE in fewer women and apparently associated with an older age at diagnosis than SLE; (3) similar frequency of cutaneous lupus subsets in CLE and SLE; (4) strong family history for SLE but not CLE in CLE patients; (5) other cutaneous and musculoskeletal features in a majority of CLE patients and constitutional symptoms in 10%; (6) positive ANA titers, high sedimentation rates, and leukopenia common in CLE; (7) anticardiolipin antibody in 31% of CLE patients but not associated with systemic complications; (8) antimalarials required by 75% of patients and systemic steroids by 33%; and (9) an excellent prognosis associated with CLE, organ-threatening disease being rare.</description><identifier>ISSN: 0049-0172</identifier><identifier>EISSN: 1532-866X</identifier><identifier>DOI: 10.1016/0049-0172(92)90052-F</identifier><identifier>PMID: 1570517</identifier><identifier>CODEN: SAHRBF</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Adult ; Antibodies - analysis ; Biological and medical sciences ; Cardiolipins - immunology ; Female ; Humans ; Lupus Erythematosus, Cutaneous - blood ; Lupus Erythematosus, Systemic - blood ; Male ; Medical sciences ; Prognosis ; Sarcoidosis. 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Clinical and laboratory features, treatment, and natural course were observed. Findings of interest included (1) a ratio of at least one CLE case for every seven cases of systemic lupus erythematosus (SLE); (2) occurrence of CLE in fewer women and apparently associated with an older age at diagnosis than SLE; (3) similar frequency of cutaneous lupus subsets in CLE and SLE; (4) strong family history for SLE but not CLE in CLE patients; (5) other cutaneous and musculoskeletal features in a majority of CLE patients and constitutional symptoms in 10%; (6) positive ANA titers, high sedimentation rates, and leukopenia common in CLE; (7) anticardiolipin antibody in 31% of CLE patients but not associated with systemic complications; (8) antimalarials required by 75% of patients and systemic steroids by 33%; and (9) an excellent prognosis associated with CLE, organ-threatening disease being rare.</description><subject>Adult</subject><subject>Antibodies - analysis</subject><subject>Biological and medical sciences</subject><subject>Cardiolipins - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Lupus Erythematosus, Cutaneous - blood</subject><subject>Lupus Erythematosus, Systemic - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Prognosis</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wallace, Daniel J.</creatorcontrib><creatorcontrib>Pistiner, Moshe</creatorcontrib><creatorcontrib>Nessim, Sharon</creatorcontrib><creatorcontrib>Metzger, Allan L.</creatorcontrib><creatorcontrib>Klinenberg, James R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wallace, Daniel J.</au><au>Pistiner, Moshe</au><au>Nessim, Sharon</au><au>Metzger, Allan L.</au><au>Klinenberg, James R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cutaneous lupus erythematosus without systemic lupus erythematosus: Clinical and laboratory features</atitle><jtitle>Seminars in arthritis and rheumatism</jtitle><addtitle>Semin Arthritis Rheum</addtitle><date>1992-02-01</date><risdate>1992</risdate><volume>21</volume><issue>4</issue><spage>221</spage><epage>226</epage><pages>221-226</pages><issn>0049-0172</issn><eissn>1532-866X</eissn><coden>SAHRBF</coden><abstract>Sixty-seven patients with cutaneous lupus erythematosus (CLE) were followed up as part of a series of 570 lupus erythematosus patients seen in a private practice between 1980 and 1989. Clinical and laboratory features, treatment, and natural course were observed. Findings of interest included (1) a ratio of at least one CLE case for every seven cases of systemic lupus erythematosus (SLE); (2) occurrence of CLE in fewer women and apparently associated with an older age at diagnosis than SLE; (3) similar frequency of cutaneous lupus subsets in CLE and SLE; (4) strong family history for SLE but not CLE in CLE patients; (5) other cutaneous and musculoskeletal features in a majority of CLE patients and constitutional symptoms in 10%; (6) positive ANA titers, high sedimentation rates, and leukopenia common in CLE; (7) anticardiolipin antibody in 31% of CLE patients but not associated with systemic complications; (8) antimalarials required by 75% of patients and systemic steroids by 33%; and (9) an excellent prognosis associated with CLE, organ-threatening disease being rare.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>1570517</pmid><doi>10.1016/0049-0172(92)90052-F</doi><tpages>6</tpages></addata></record> |
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| ispartof | Seminars in arthritis and rheumatism, 1992-02, Vol.21 (4), p.221-226 |
| issn | 0049-0172 1532-866X |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Antibodies - analysis Biological and medical sciences Cardiolipins - immunology Female Humans Lupus Erythematosus, Cutaneous - blood Lupus Erythematosus, Systemic - blood Male Medical sciences Prognosis Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis |
| title | Cutaneous lupus erythematosus without systemic lupus erythematosus: Clinical and laboratory features |
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