A system-approach method for the adjustment of time-varying continuous drug infusion in individual patients: A simulation study
The aim of this simulation study was to present a system-approach method for adjustment of continuous drug infusions at time-varying rates, aimed at achieving and then maintaining required drug concentration-time profiles in patients. The method presented can be used for safe and cost-effective indi...
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| Veröffentlicht in: | Journal of pharmacokinetics and pharmacodynamics 2002-12, Vol.29 (5-6), p.427-444 |
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| container_end_page | 444 |
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| container_issue | 5-6 |
| container_start_page | 427 |
| container_title | Journal of pharmacokinetics and pharmacodynamics |
| container_volume | 29 |
| creator | DURISOVA, Maria DEDIK, Ladislav |
| description | The aim of this simulation study was to present a system-approach method for adjustment of continuous drug infusions at time-varying rates, aimed at achieving and then maintaining required drug concentration-time profiles in patients. The method presented can be used for safe and cost-effective individualization of drug dosing by computer-controlled infusion pumps. Utilization of this method is exemplified by simulation experiments, aimed at adjusting continuous infusions of Factor VIII (FVIII) at time-varying rates, which would theoretically yield required concentration-time profiles of FVIII in hemophilia A patients over several days. |
| doi_str_mv | 10.1023/A:1022968319095 |
| format | Article |
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The method presented can be used for safe and cost-effective individualization of drug dosing by computer-controlled infusion pumps. Utilization of this method is exemplified by simulation experiments, aimed at adjusting continuous infusions of Factor VIII (FVIII) at time-varying rates, which would theoretically yield required concentration-time profiles of FVIII in hemophilia A patients over several days.</description><identifier>ISSN: 1567-567X</identifier><identifier>EISSN: 1573-8744</identifier><identifier>DOI: 10.1023/A:1022968319095</identifier><identifier>PMID: 12795240</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Algorithms ; Biological and medical sciences ; Computer Simulation ; Factor VIII - administration & dosage ; Factor VIII - pharmacokinetics ; General pharmacology ; Hemophilia A - blood ; Humans ; Infusions, Intravenous ; Medical sciences ; Models, Biological ; Pharmaceutical Preparations - administration & dosage ; Pharmacokinetics ; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions ; Pharmacology. 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The method presented can be used for safe and cost-effective individualization of drug dosing by computer-controlled infusion pumps. Utilization of this method is exemplified by simulation experiments, aimed at adjusting continuous infusions of Factor VIII (FVIII) at time-varying rates, which would theoretically yield required concentration-time profiles of FVIII in hemophilia A patients over several days.</description><subject>Algorithms</subject><subject>Biological and medical sciences</subject><subject>Computer Simulation</subject><subject>Factor VIII - administration & dosage</subject><subject>Factor VIII - pharmacokinetics</subject><subject>General pharmacology</subject><subject>Hemophilia A - blood</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Pharmaceutical Preparations - administration & dosage</subject><subject>Pharmacokinetics</subject><subject>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</subject><subject>Pharmacology. Drug treatments</subject><subject>Simulation</subject><subject>Studies</subject><issn>1567-567X</issn><issn>1573-8744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkMtr3DAQh0VpaZ7n3oIoNDcnkiVZUm5LaNJAoJcUcjNjPbJabHlrSQt7yr9ehW4oFGaY38A3T4S-UHJFScuuVzc1tLpTjGqixQd0TIVkjZKcf3zTnWyqPx-hk5Q2hNBOtOQzOqKt1KLl5Bi9rnDap-ymBrbbZQazxpPL69liPy84rx0GuykpTy5mPHucw-SaHSz7EF-wmWMOscwlYbuUFxyiLynMsYpqNuyCLTDiLeRQy9MNrsPCVMaaVyjlYvdn6JOHMbnzQzxFv-6-P93-aB5_3j_crh4bwyjJDZOaez4ID53QrrWgpWCgCaecSrCuU9x0A2PQSWnUQKyn4K0bJFWDot6wU3T5t2898ndxKfdTSMaNI0RX9-9lq7QWnFXw63_gZi5LrLv1UkjClNSyQhcHqAyTs_12CVP9Sf_-1wp8OwCQDIx-gWhC-sdxqXSrOvYHkhqJWg</recordid><startdate>20021201</startdate><enddate>20021201</enddate><creator>DURISOVA, Maria</creator><creator>DEDIK, Ladislav</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20021201</creationdate><title>A system-approach method for the adjustment of time-varying continuous drug infusion in individual patients: A simulation study</title><author>DURISOVA, Maria ; DEDIK, Ladislav</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-3794f4b5fa659e2da9753a9041417ade684c6b33a677c8b0df1afdeb718b81fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Algorithms</topic><topic>Biological and medical sciences</topic><topic>Computer Simulation</topic><topic>Factor VIII - administration & dosage</topic><topic>Factor VIII - pharmacokinetics</topic><topic>General pharmacology</topic><topic>Hemophilia A - blood</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>Pharmaceutical Preparations - administration & dosage</topic><topic>Pharmacokinetics</topic><topic>Pharmacokinetics. 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| fulltext | fulltext |
| identifier | ISSN: 1567-567X |
| ispartof | Journal of pharmacokinetics and pharmacodynamics, 2002-12, Vol.29 (5-6), p.427-444 |
| issn | 1567-567X 1573-8744 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72899543 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Algorithms Biological and medical sciences Computer Simulation Factor VIII - administration & dosage Factor VIII - pharmacokinetics General pharmacology Hemophilia A - blood Humans Infusions, Intravenous Medical sciences Models, Biological Pharmaceutical Preparations - administration & dosage Pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Simulation Studies |
| title | A system-approach method for the adjustment of time-varying continuous drug infusion in individual patients: A simulation study |
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