Energy restriction and testosterone implants alter ornithine decarboxylase gene expression in kidney of female rats
Effects of testosterone and energy restriction (30%) on enzyme activity and mRNA level of ornithine decarboxylase (ODC) were studied in 19-wk-old female Sprague-Dawley rats. Testosterone implantation for 1 wk elicited a sixfold increase in ODC activity and a fourfold increase in ODC mRNA transcripts...
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| Veröffentlicht in: | The Journal of nutrition 1992-05, Vol.122 (5), p.1056-1061 |
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| container_end_page | 1061 |
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| container_issue | 5 |
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| container_title | The Journal of nutrition |
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| creator | BAIK, M HARROLD, R. L CHOI, C. B SLANGER, W. D SUNG, S. K PARK, C. S |
| description | Effects of testosterone and energy restriction (30%) on enzyme activity and mRNA level of ornithine decarboxylase (ODC) were studied in 19-wk-old female Sprague-Dawley rats. Testosterone implantation for 1 wk elicited a sixfold increase in ODC activity and a fourfold increase in ODC mRNA transcripts in the kidney. Energy restriction also increased renal ODC activity. Further, the 56% increase in ODC enzyme activity observed in the testosterone-implanted, energy-restricted group was greater than the 24% increase in the placebo-implanted, energy-restricted group. No changes in renal ODC mRNA levels were observed in the energy-restricted groups. These observations suggest that translational or post-translational mechanism(s) are involved in the greater renal ODC activity in energy-restricted rats. |
| doi_str_mv | 10.1093/jn/122.5.1056 |
| format | Article |
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These observations suggest that translational or post-translational mechanism(s) are involved in the greater renal ODC activity in energy-restricted rats.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/122.5.1056</identifier><identifier>PMID: 1564558</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Nutritional Sciences</publisher><subject>Animals ; Biological and medical sciences ; Diet ; Energy Metabolism ; Enzymes. Coenzymes. Vitamins. Pigments ; Estradiol - blood ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression - drug effects ; Genetics ; Hormones ; Kidney - drug effects ; Kidney - enzymology ; Kidneys ; Metabolisms and neurohumoral controls ; Ornithine Decarboxylase - genetics ; Ornithine Decarboxylase - metabolism ; Rats ; Rats, Inbred Strains ; RNA, Messenger - analysis ; Rodents ; Testosterone - blood ; Testosterone - pharmacology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>The Journal of nutrition, 1992-05, Vol.122 (5), p.1056-1061</ispartof><rights>1992 INIST-CNRS</rights><rights>Copyright American Institute of Nutrition May 1992</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-e0d7bb8fd4b6ed661b0109f19c43ce215a147c7ff08b63b302a76953a35bca293</citedby><cites>FETCH-LOGICAL-c383t-e0d7bb8fd4b6ed661b0109f19c43ce215a147c7ff08b63b302a76953a35bca293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5255449$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1564558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BAIK, M</creatorcontrib><creatorcontrib>HARROLD, R. 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No changes in renal ODC mRNA levels were observed in the energy-restricted groups. These observations suggest that translational or post-translational mechanism(s) are involved in the greater renal ODC activity in energy-restricted rats.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Diet</subject><subject>Energy Metabolism</subject><subject>Enzymes. Coenzymes. Vitamins. Pigments</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression - drug effects</subject><subject>Genetics</subject><subject>Hormones</subject><subject>Kidney - drug effects</subject><subject>Kidney - enzymology</subject><subject>Kidneys</subject><subject>Metabolisms and neurohumoral controls</subject><subject>Ornithine Decarboxylase - genetics</subject><subject>Ornithine Decarboxylase - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>RNA, Messenger - analysis</subject><subject>Rodents</subject><subject>Testosterone - blood</subject><subject>Testosterone - pharmacology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtrHDEQhEVIsNdOjjkGRDC-ja23Zo7B-AUGX5KzkDQtR5sZaS3NgvffW8suCeQkuuujUHUh9JWSK0oGfr1O15SxK9kmqT6gFZWCdooS8hGtCGGs41SpU3RW65oQQsXQn6ATKpWQsl-hepugvOxwgbqU6JeYE7ZpxEubc12g5AQ4zpvJpqViO7UNziXF5XdswgjeFpffdpOtgF-greBt07zq3icm_CeOCXY4BxxgthPgYpf6GX0Kdqrw5fieo193tz9vHrqn5_vHmx9Pnec9Xzogo3auD6NwCkalqCMtcKCDF9wDo9JSob0OgfROcccJs1oNklsunbds4Ofo8uC7Kfl12wKZOVYPU8sCeVuNZv2gKeEN_P4fuM7bktrfDB20EFRr1qDuAPmSay0QzKbE2ZadocTsmzDrZFoTRpp9E43_djTduhnGf_Th9E2_OOq2ejuFYpOP9S8mmZRCDPwdGC-Sow</recordid><startdate>19920501</startdate><enddate>19920501</enddate><creator>BAIK, M</creator><creator>HARROLD, R. 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S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Energy restriction and testosterone implants alter ornithine decarboxylase gene expression in kidney of female rats</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1992-05-01</date><risdate>1992</risdate><volume>122</volume><issue>5</issue><spage>1056</spage><epage>1061</epage><pages>1056-1061</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>Effects of testosterone and energy restriction (30%) on enzyme activity and mRNA level of ornithine decarboxylase (ODC) were studied in 19-wk-old female Sprague-Dawley rats. Testosterone implantation for 1 wk elicited a sixfold increase in ODC activity and a fourfold increase in ODC mRNA transcripts in the kidney. Energy restriction also increased renal ODC activity. Further, the 56% increase in ODC enzyme activity observed in the testosterone-implanted, energy-restricted group was greater than the 24% increase in the placebo-implanted, energy-restricted group. No changes in renal ODC mRNA levels were observed in the energy-restricted groups. These observations suggest that translational or post-translational mechanism(s) are involved in the greater renal ODC activity in energy-restricted rats.</abstract><cop>Bethesda, MD</cop><pub>American Society for Nutritional Sciences</pub><pmid>1564558</pmid><doi>10.1093/jn/122.5.1056</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of nutrition, 1992-05, Vol.122 (5), p.1056-1061 |
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| subjects | Animals Biological and medical sciences Diet Energy Metabolism Enzymes. Coenzymes. Vitamins. Pigments Estradiol - blood Female Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Genetics Hormones Kidney - drug effects Kidney - enzymology Kidneys Metabolisms and neurohumoral controls Ornithine Decarboxylase - genetics Ornithine Decarboxylase - metabolism Rats Rats, Inbred Strains RNA, Messenger - analysis Rodents Testosterone - blood Testosterone - pharmacology Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Energy restriction and testosterone implants alter ornithine decarboxylase gene expression in kidney of female rats |
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