Neural Cell Adhesion Molecule-Positive Peripheral T-Cell Lymphoma: A Rare Variant With a Propensity for Unusual Sites of Involvement
A distinct subset of patients with peripheral T-cell lymphoma (PTCL) is described which reacts with Leu-19 (CD56), an antibody that has been shown to identify the neural cell adhesion molecule (NCAM). These NCAM-positive PTCL patients (11 of a series of 46 PTCL; 24%) exhibited a striking predilectio...
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| Veröffentlicht in: | Blood 1992-05, Vol.79 (9), p.2432-2437 |
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| creator | Kern, W.F. Spier, C.M. Hanneman, E.H. Miller, T.P. Matzner, M. Grogan, T.M. |
| description | A distinct subset of patients with peripheral T-cell lymphoma (PTCL) is described which reacts with Leu-19 (CD56), an antibody that has been shown to identify the neural cell adhesion molecule (NCAM). These NCAM-positive PTCL patients (11 of a series of 46 PTCL; 24%) exhibited a striking predilection for unusual anatomic sites of involvement: central nervous system (36%), muscle (18%), gastrointestinal tract, and nasopharynx (27% each). Additional extranodal sites of involvement included the pituitary, thyroid, parathyroids, adrenals, and pancreas. The NCAM-positive subset also exhibited a characteristic phenotypic profile, with signif-icantly lower expression of CD3 and CD5 compared with the NCAM-negative group. RNA transcripts consistent with the NCAM gene were detected in tissue samples from five Leu-19-positive cases using a reverse transcriptase-poly-merase chain reaction assay, supporting the idea that Leu-19 recognizes NCAM in these patient samples. This suggests that the expression of the NCAM plays a role in the behavior and localization of lymphomas. Because of the unique clinical and phenotypic characteristics of this group it may be designated as “NCAM-positive peripheral T-cell lymphoma.” |
| doi_str_mv | 10.1182/blood.V79.9.2432.2432 |
| format | Article |
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These NCAM-positive PTCL patients (11 of a series of 46 PTCL; 24%) exhibited a striking predilection for unusual anatomic sites of involvement: central nervous system (36%), muscle (18%), gastrointestinal tract, and nasopharynx (27% each). Additional extranodal sites of involvement included the pituitary, thyroid, parathyroids, adrenals, and pancreas. The NCAM-positive subset also exhibited a characteristic phenotypic profile, with signif-icantly lower expression of CD3 and CD5 compared with the NCAM-negative group. RNA transcripts consistent with the NCAM gene were detected in tissue samples from five Leu-19-positive cases using a reverse transcriptase-poly-merase chain reaction assay, supporting the idea that Leu-19 recognizes NCAM in these patient samples. This suggests that the expression of the NCAM plays a role in the behavior and localization of lymphomas. Because of the unique clinical and phenotypic characteristics of this group it may be designated as “NCAM-positive peripheral T-cell lymphoma.”</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.V79.9.2432.2432</identifier><identifier>PMID: 1373974</identifier><language>eng</language><publisher>WASHINGTON: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antigens, CD - analysis ; Base Sequence ; Biological and medical sciences ; Cell Adhesion Molecules, Neuronal - analysis ; Cell Adhesion Molecules, Neuronal - genetics ; Female ; Hematologic and hematopoietic diseases ; Hematology ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Life Sciences & Biomedicine ; Lymphoma, T-Cell, Peripheral - immunology ; Lymphoma, T-Cell, Peripheral - metabolism ; Lymphoma, T-Cell, Peripheral - pathology ; Male ; Medical sciences ; Middle Aged ; Molecular Sequence Data ; Phenotype ; RNA - analysis ; Science & Technology</subject><ispartof>Blood, 1992-05, Vol.79 (9), p.2432-2437</ispartof><rights>1992 American Society of Hematology</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>220</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wosA1992HW88400033</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c436t-785f47b5282f6d25cd262de508eee6b33416b811614d1d9f153106d05f023b783</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27201,27933,27934</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5339275$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1373974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kern, W.F.</creatorcontrib><creatorcontrib>Spier, C.M.</creatorcontrib><creatorcontrib>Hanneman, E.H.</creatorcontrib><creatorcontrib>Miller, T.P.</creatorcontrib><creatorcontrib>Matzner, M.</creatorcontrib><creatorcontrib>Grogan, T.M.</creatorcontrib><title>Neural Cell Adhesion Molecule-Positive Peripheral T-Cell Lymphoma: A Rare Variant With a Propensity for Unusual Sites of Involvement</title><title>Blood</title><addtitle>BLOOD</addtitle><addtitle>Blood</addtitle><description>A distinct subset of patients with peripheral T-cell lymphoma (PTCL) is described which reacts with Leu-19 (CD56), an antibody that has been shown to identify the neural cell adhesion molecule (NCAM). These NCAM-positive PTCL patients (11 of a series of 46 PTCL; 24%) exhibited a striking predilection for unusual anatomic sites of involvement: central nervous system (36%), muscle (18%), gastrointestinal tract, and nasopharynx (27% each). Additional extranodal sites of involvement included the pituitary, thyroid, parathyroids, adrenals, and pancreas. The NCAM-positive subset also exhibited a characteristic phenotypic profile, with signif-icantly lower expression of CD3 and CD5 compared with the NCAM-negative group. RNA transcripts consistent with the NCAM gene were detected in tissue samples from five Leu-19-positive cases using a reverse transcriptase-poly-merase chain reaction assay, supporting the idea that Leu-19 recognizes NCAM in these patient samples. This suggests that the expression of the NCAM plays a role in the behavior and localization of lymphomas. Because of the unique clinical and phenotypic characteristics of this group it may be designated as “NCAM-positive peripheral T-cell lymphoma.”</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens, CD - analysis</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion Molecules, Neuronal - analysis</subject><subject>Cell Adhesion Molecules, Neuronal - genetics</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Life Sciences & Biomedicine</subject><subject>Lymphoma, T-Cell, Peripheral - immunology</subject><subject>Lymphoma, T-Cell, Peripheral - metabolism</subject><subject>Lymphoma, T-Cell, Peripheral - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Sequence Data</subject><subject>Phenotype</subject><subject>RNA - analysis</subject><subject>Science & Technology</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EZCTM</sourceid><sourceid>EIF</sourceid><recordid>eNqNkU2P0zAQhiMEWroLP2ElHxAXlOKPOHG4oCoCdqUCFezH0XLiiWqUxFnbKep9fzhuUy1HuMwc5nlszTtJcknwkhBB39edtXp5V5TLckkzRo_lWbIgnIoUY4qfJwuMcZ5mZUFeJufe_8KYRIafJWeEFawsskXy-A0mpzpUQdehld6CN3ZAX20HzdRBurHeBLMDtAFnxi0c0Jv0CK_3_bi1vfqAVuiHcoDulDNqCOjehC1SaOPsCEPU96i1Dt0Ok5-i_dME8Mi26HrY2W4HPQzhVfKiVZ2H16d-kdx-_nRTXaXr71-uq9U6bTKWh7QQvM2KOu5H21xT3miaUw0cCwDIa8YykteCkJxkmuiyJZwRnGvMW0xZXQh2kbyd3x2dfZjAB9kb38Rl1AB28rKgouQizyLIZ7Bx1nsHrRyd6ZXbS4LlIX15TF_G9GUpD8EfS_QuTx9MdQ_6rzXHHedvTnPlG9W1Tg2N8U8YZ6ykBY-YmLHfUNvWNwaGBp6oFSlLenUvRBbPy1hlggrxaJWdhhDVd_-vRvrjTENMfWfAyZOhjYMmSG3NPzb-A9JZxWw</recordid><startdate>19920501</startdate><enddate>19920501</enddate><creator>Kern, W.F.</creator><creator>Spier, C.M.</creator><creator>Hanneman, E.H.</creator><creator>Miller, T.P.</creator><creator>Matzner, M.</creator><creator>Grogan, T.M.</creator><general>Elsevier Inc</general><general>Amer Soc Hematology</general><general>The Americain Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>BLEPL</scope><scope>DTL</scope><scope>EZCTM</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19920501</creationdate><title>Neural Cell Adhesion Molecule-Positive Peripheral T-Cell Lymphoma: A Rare Variant With a Propensity for Unusual Sites of Involvement</title><author>Kern, W.F. ; Spier, C.M. ; Hanneman, E.H. ; Miller, T.P. ; Matzner, M. ; Grogan, T.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-785f47b5282f6d25cd262de508eee6b33416b811614d1d9f153106d05f023b783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens, CD - analysis</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cell Adhesion Molecules, Neuronal - analysis</topic><topic>Cell Adhesion Molecules, Neuronal - genetics</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Life Sciences & Biomedicine</topic><topic>Lymphoma, T-Cell, Peripheral - immunology</topic><topic>Lymphoma, T-Cell, Peripheral - metabolism</topic><topic>Lymphoma, T-Cell, Peripheral - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Sequence Data</topic><topic>Phenotype</topic><topic>RNA - analysis</topic><topic>Science & Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kern, W.F.</creatorcontrib><creatorcontrib>Spier, C.M.</creatorcontrib><creatorcontrib>Hanneman, E.H.</creatorcontrib><creatorcontrib>Miller, T.P.</creatorcontrib><creatorcontrib>Matzner, M.</creatorcontrib><creatorcontrib>Grogan, T.M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 1992</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kern, W.F.</au><au>Spier, C.M.</au><au>Hanneman, E.H.</au><au>Miller, T.P.</au><au>Matzner, M.</au><au>Grogan, T.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural Cell Adhesion Molecule-Positive Peripheral T-Cell Lymphoma: A Rare Variant With a Propensity for Unusual Sites of Involvement</atitle><jtitle>Blood</jtitle><stitle>BLOOD</stitle><addtitle>Blood</addtitle><date>1992-05-01</date><risdate>1992</risdate><volume>79</volume><issue>9</issue><spage>2432</spage><epage>2437</epage><pages>2432-2437</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>A distinct subset of patients with peripheral T-cell lymphoma (PTCL) is described which reacts with Leu-19 (CD56), an antibody that has been shown to identify the neural cell adhesion molecule (NCAM). These NCAM-positive PTCL patients (11 of a series of 46 PTCL; 24%) exhibited a striking predilection for unusual anatomic sites of involvement: central nervous system (36%), muscle (18%), gastrointestinal tract, and nasopharynx (27% each). Additional extranodal sites of involvement included the pituitary, thyroid, parathyroids, adrenals, and pancreas. The NCAM-positive subset also exhibited a characteristic phenotypic profile, with signif-icantly lower expression of CD3 and CD5 compared with the NCAM-negative group. RNA transcripts consistent with the NCAM gene were detected in tissue samples from five Leu-19-positive cases using a reverse transcriptase-poly-merase chain reaction assay, supporting the idea that Leu-19 recognizes NCAM in these patient samples. This suggests that the expression of the NCAM plays a role in the behavior and localization of lymphomas. Because of the unique clinical and phenotypic characteristics of this group it may be designated as “NCAM-positive peripheral T-cell lymphoma.”</abstract><cop>WASHINGTON</cop><pub>Elsevier Inc</pub><pmid>1373974</pmid><doi>10.1182/blood.V79.9.2432.2432</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Blood, 1992-05, Vol.79 (9), p.2432-2437 |
| issn | 0006-4971 1528-0020 |
| language | eng |
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| source | Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Antigens, CD - analysis Base Sequence Biological and medical sciences Cell Adhesion Molecules, Neuronal - analysis Cell Adhesion Molecules, Neuronal - genetics Female Hematologic and hematopoietic diseases Hematology Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Life Sciences & Biomedicine Lymphoma, T-Cell, Peripheral - immunology Lymphoma, T-Cell, Peripheral - metabolism Lymphoma, T-Cell, Peripheral - pathology Male Medical sciences Middle Aged Molecular Sequence Data Phenotype RNA - analysis Science & Technology |
| title | Neural Cell Adhesion Molecule-Positive Peripheral T-Cell Lymphoma: A Rare Variant With a Propensity for Unusual Sites of Involvement |
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