Hypoxic up-regulation of erythroid 5-aminolevulinate synthase

The erythroid-specific isoform of 5-aminolevulinate synthase (ALAS2) catalyzes the rate-limiting step in heme biosynthesis. The hypoxia-inducible factor–1 (HIF-1) transcriptionally up-regulates erythropoietin, transferrin, and transferrin receptor, leading to increased erythropoiesis and hematopoiet...

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Veröffentlicht in:	Blood 2003-01, Vol.101 (1), p.348-350
Hauptverfasser:	Hofer, Thomas, Wenger, Roland H., Kramer, Marianne F., Ferreira, Gloria C., Gassmann, Max
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Aminolevulinate Synthetase - genetics Animals Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology DNA-Binding Proteins Erythrocytes - enzymology Fundamental and applied biological sciences. Psychology HeLa Cells Heme - metabolism Humans Hypoxia - enzymology Hypoxia-Inducible Factor 1 Hypoxia-Inducible Factor 1, alpha Subunit Iron - pharmacology Mice Molecular and cellular biology Nuclear Proteins Promoter Regions, Genetic RNA, Messenger - biosynthesis Transcription Factors Up-Regulation
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