Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons

Drug transporters are an important part of the defense of cells against cytotoxic agents. One major group of transporters is known as multidrug resistance associated proteins (MRP; ABCC gene family). The MRPs belong to the ATP binding cassette transporter superfamily. One family member, ABCC4 (also...

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Veröffentlicht in:	Human molecular genetics 2003-01, Vol.12 (2), p.99-109
Hauptverfasser:	Lamba, Jatinder Kaur, Adachi, Masashi, Sun, Daxi, Tammur, Jaana, Schuetz, Erin G., Allikmets, Rando, Schuetz, John D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - genetics Animals Base Sequence Biological and medical sciences Cell Line Codon, Nonsense - genetics Codon, Terminator - genetics Conserved Sequence Down-Regulation Exons Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Haplorhini Humans Mice Molecular and cellular biology Molecular genetics Molecular Sequence Data Multidrug Resistance-Associated Proteins - genetics Mutation RNA, Messenger - genetics RNA, Messenger - metabolism Transcription, Genetic
Online-Zugang:	Volltext
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