Smoke exposure, histologic type and geography‐related differences in the methylation profiles of non‐small cell lung cancer

Aberrant methylation of several known or putative tumor suppressor genes occurs frequently during the pathogenesis of lung cancers. There are major smoke exposure, histology, geography and gender‐related changes in non‐small cell lung cancer (NSCLC). We investigated smoking‐related, histologic, geog...

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Veröffentlicht in:	International journal of cancer 2003-01, Vol.103 (2), p.153-160
Hauptverfasser:	Toyooka, Shinichi, Maruyama, Riichiroh, Toyooka, Kiyomi O., McLerran, Dale, Feng, Ziding, Fukuyama, Yasuro, Virmani, Arvind K., Zochbauer‐Muller, Sabine, Tsukuda, Kazunori, Sugio, Kenji, Shimizu, Nobuyoshi, Shimizu, Kenji, Lee, Huei, Chen, Chih‐Yi, Fong, Kwun M., Gilcrease, Michael, Roth, Jack A., Minna, John D., Gazdar, Adi F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenomatous Polyposis Coli Protein - genetics Adult Aged Aged, 80 and over Australia Biological and medical sciences Cadherins - genetics Carcinoma, Non-Small-Cell Lung - etiology Carcinoma, Non-Small-Cell Lung - genetics Cyclin-Dependent Kinase Inhibitor p16 - genetics DNA Methylation DNA, Neoplasm Female Genes, Tumor Suppressor Glutathione S-Transferase pi Glutathione Transferase - genetics histology Humans Isoenzymes - genetics Japan Lung Neoplasms - etiology Lung Neoplasms - genetics Male Medical sciences methylation Middle Aged Neoplasm Proteins - genetics non‐small cell lung cancer O-Methylguanine-DNA Methyltransferase - genetics Pneumology Polymerase Chain Reaction - methods Promoter Regions, Genetic - genetics Receptors, Retinoic Acid - genetics Risk Factors smoking Smoking - adverse effects Survival Rate Taiwan Tumor Suppressor Proteins Tumors of the respiratory system and mediastinum United States
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