Enhanced calcium signaling and acid secretion in parietal cells isolated from gastrin-deficient mice

Gastrin-deficient mice have impaired basal and agonist-stimulated gastric acid secretion. To analyze whether an intrinsic parietal cell defect contributed to the reduced acid secretion, we analyzed parietal cell calcium responses and acid secretory function in vitro. Parietal cells were purified by...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2003-01, Vol.284 (1), p.G145-G153
Hauptverfasser:	Hinkle, Karen L, Bane, Gina C, Jazayeri, Ali, Samuelson, Linda C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyrine - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Calcium Signaling - drug effects Calcium Signaling - physiology Carbachol - pharmacology Carbon Radioisotopes Cell Separation Cholinergic Agonists - pharmacology Flow Cytometry Gastric Acid - secretion Gastrins - genetics Gastrins - pharmacology Histamine - pharmacology In Vitro Techniques Mice Mice, Mutant Strains Parietal Cells, Gastric - cytology Parietal Cells, Gastric - metabolism Parietal Cells, Gastric - secretion
Online-Zugang:	Volltext
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